ID F7EBN2_MACMU Unreviewed; 727 AA.
AC F7EBN2; I0FQ18;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 2.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Ankyrin repeat domain 6 {ECO:0000313|Ensembl:ENSMMUP00000004610.3};
DE SubName: Full=Ankyrin repeat domain-containing protein 6 isoform a {ECO:0000313|EMBL:AFI36544.1};
GN Name=ANKRD6 {ECO:0000313|EMBL:AFI36544.1,
GN ECO:0000313|Ensembl:ENSMMUP00000004610.3,
GN ECO:0000313|VGNC:VGNC:81023};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000004610.3, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|EMBL:AFI36544.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Testis {ECO:0000313|EMBL:AFI36544.1};
RX PubMed=25319552; DOI=10.1186/1745-6150-9-20;
RA Zimin A.V., Cornish A.S., Maudhoo M.D., Gibbs R.M., Zhang X., Pandey S.,
RA Meehan D.T., Wipfler K., Bosinger S.E., Johnson Z.P., Tharp G.K.,
RA Marcais G., Roberts M., Ferguson B., Fox H.S., Treangen T., Salzberg S.L.,
RA Yorke J.A., Norgren R.B.Jr.;
RT "A new rhesus macaque assembly and annotation for next-generation
RT sequencing analyses.";
RL Biol. Direct 9:20-20(2014).
RN [3] {ECO:0000313|Ensembl:ENSMMUP00000004610.3}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000004610.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JV046473; AFI36544.1; -; mRNA.
DR RefSeq; NP_001248646.1; NM_001261717.2.
DR RefSeq; XP_014992376.1; XM_015136890.1.
DR RefSeq; XP_014992378.1; XM_015136892.1.
DR RefSeq; XP_014992379.1; XM_015136893.1.
DR PaxDb; 9544-ENSMMUP00000004610; -.
DR Ensembl; ENSMMUT00000004895.4; ENSMMUP00000004610.3; ENSMMUG00000003462.4.
DR GeneID; 701339; -.
DR KEGG; mcc:701339; -.
DR CTD; 22881; -.
DR VEuPathDB; HostDB:ENSMMUG00000003462; -.
DR VGNC; VGNC:81023; ANKRD6.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00940000155887; -.
DR HOGENOM; CLU_027072_0_0_1; -.
DR OrthoDB; 5482154at2759; -.
DR TreeFam; TF332587; -.
DR Proteomes; UP000006718; Chromosome 4.
DR Bgee; ENSMMUG00000003462; Expressed in prefrontal cortex and 21 other cell types or tissues.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR PANTHER; PTHR24188:SF29; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24188; ANKYRIN REPEAT PROTEIN; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 2.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 8.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 6.
DR PROSITE; PS50088; ANK_REPEAT; 6.
PE 2: Evidence at transcript level;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718}.
FT REPEAT 41..73
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 74..106
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 107..139
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 140..172
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 173..205
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 206..238
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 277..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 520..586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 601..657
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 695..722
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 277..292
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 312..345
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 365..379
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 520..549
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 565..586
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 612..647
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 727 AA; 79834 MW; BA07F611150F3AB6 CRC64;
MSQQDAVAAL SERLLIAAYK GQTENVVQLI NKGAKVAVTK HGRTPLHLAA NKGHLPVVQI
LLKAGCDLDV QDDGDQTALH RATVVGNTEI IAALIHEGCA LDRQDKDGNT ALHEASWHGF
SQSAKLLVKA GANVLAKNKA GNTALHLACQ NSHSQSTRVL LLAGSRADLK NNAGDTCLHV
AARYNHLSII RLLLSAFCSV HEKNQAGDTA LHIAAALNHK KVAKILLEAG ADTTIVNNAG
QTPLETARCH NNPEVALLLT KAPQVLRFSR GRSLRKKRER LKEERRAQSV PRDEVAQSKG
SVSAGDTPSS EQAVARREEA REEFLSASPE PRAKDDRRRK SRPKVSAFSD PTPPADQQPG
HQKNLHAHNH PKKRNRHRCS SPPPPHEFRA YQLYTLYRGK DGKVMQAPIN GCRCEPLINK
LENQLEATVE EIKAELGSVQ DKMNTKLGQM ENKTQHQMRV LDKLMVERLS AERTECLNRL
QQHSDAEKHE GEKRQISLVD ELKTWCMLKI QNLEQKLSGD SRACRAKSTP STCESSTGVD
QSVVTAGPAA ASDSSPPVVR PKEKALNSTA TQRLQQELSS SDCTGSRLRN VKVQTALLPM
NEAARSDHQA GPCVNRGTQT KKSGKSGPTR HRAQQPTASS TCGQPPPAAG GEQTGPHIRD
TSQALELTQY FFEAVSTQME KWYERKIEEA RSQANQKAQQ DKATLKEHIK SLEEELAKLR
TRVQKEN
//
