ID F7EE40_MACMU Unreviewed; 2074 AA.
AC F7EE40;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=SET binding factor 1 {ECO:0000313|Ensembl:ENSMMUP00000011923.4};
GN Name=SBF1 {ECO:0000313|Ensembl:ENSMMUP00000011923.4,
GN ECO:0000313|VGNC:VGNC:98440};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000011923.4, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000011923.4}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000011923.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR SMR; F7EE40; -.
DR Ensembl; ENSMMUT00000012714.4; ENSMMUP00000011923.4; ENSMMUG00000009082.4.
DR VEuPathDB; HostDB:ENSMMUG00000009082; -.
DR VGNC; VGNC:98440; SBF1.
DR GeneTree; ENSGT00940000155263; -.
DR Proteomes; UP000006718; Chromosome 10.
DR Bgee; ENSMMUG00000009082; Expressed in cerebellar cortex and 20 other cell types or tissues.
DR ExpressionAtlas; F7EE40; baseline.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR CDD; cd01235; PH_Sbf1_hMTMR5; 1.
DR CDD; cd14588; PTP-MTMR5; 1.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR022096; SBF1/SBF2.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF43; MYOTUBULARIN-RELATED PROTEIN 5; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF02893; GRAM; 1.
DR Pfam; PF06602; Myotub-related; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF12335; SBF2; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00568; GRAM; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00800; uDENN; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718}.
FT DOMAIN 103..535
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT DOMAIN 1216..1692
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
FT DOMAIN 1857..1909
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 19..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 187..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1159..1211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1363..1413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1701..1726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1778..1797
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1819..1850
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1168..1184
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1194..1211
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2074 AA; 229545 MW; 7A2914CF677806DD CRC64;
MGGEPPSYLL DQWRCAVEGP AHSGRDDSTQ AHGAPGRAGW LGRWRREPGP PPPPQSEPGV
SGVRGLAPGP GHERAALESP SRGARPRPSG RPASLAMARL ADYFVLVAFG PHPRGSGEGQ
GQILQRFPEK DWEDNPFPQG IELFCQPSGW QLCPERNPPT FFVAVLTDIN SERHYCACLT
FWEPVEPSQE TTREEDAPER EEEEDEGGQT HLSPTAPAPS AQLFAPKTLV LVSRLDHAEV
FRNSLGLIYA IHVEGLNVCL ENVIGNLLTC TVPLAGGSQR TISLGAGDRQ VIQTPLADSL
PVSRCSVALL FRQLGITNVL SLFCAALTEH KVLFLSRSYQ RLADACRGLL ALLFPLRYSF
TYVPILPAQL LEVLSTPTPF IIGVNAAFQA ETQELLDVIV ADLDGGTVAI PECVHIPPLP
EPLQSQTHSV LSMVLDPELE LADLAFPPPT TSTSSLKMQD KELRAVFLRL FAQLLQGYRW
CLHVVRVHPE PVIRFHKAAF LGQRGLVEDD FLMKVLEGMA FAGFVSERGV PYRPTDLFDE
LVAHEVARMR ADENHPQRVL RHVQELAEQL YKNENPYPAV AMHKVQRPGE SSHLRRVPRP
FPRLDEGTVQ WIVDQAAAKM QGAPPAVKAE RRTTVPSGPP MTAILERCSG LHVNSARRLE
VVRNCISYVF EGKMLEAKKL LPAVLRALKG RAARRCLAQE LHLHVQQNRA VLDHQQFDFV
VRMMNCCLQD CTSLDEHGIA AALLPLVTAF CRKLSPGVTQ FAYSCVQEHV VWSTPQFWEA
MFYGDVQTHI RALYLEPTED LAPAQEVGEA PSQEDERSAL DVASEQRRLW PTLSREKQQE
LVQKEESTVF SQAIHYANRM SYLLLPLDSS KSRLLRERAG LGDLESASNS LVTNSMAGSV
AESYDTESGF EDAETCDVAG AVVRFINRFV DKVCTESGVT SDHLKGLHVM VPDIVQMHIE
TLEAVQRESR RLPPIQKPKL LRPRLLPGEE CVLDGLRVYL LPDGREEGAG GSAGGPALLP
AEGAVFLTTY RVIFTGMPTD PLVGEQVVVR SFPVAALTKE KRISVQTPVD QLLQDGLQLR
SCTFQLLKMA FDEEVGSDSA ELFRKQLHKL RYPPDVRATF AFTLGSAHTP GRPPRVTKDK
GPSLRTLSRN LVKNAKKTIG RQHVTRKKYN PPSWEHRGQP PPEDQEDEIS VSEELEPSTL
TPSSALKPSD RMTMSSLVER ACCRDYQRLG LGTLSSSLSR AKSEPFRISP VNRMYAICRS
YPGLLIVPQS VQDNALQRVS RCYRQNRFPV VCWRSGRSKA VLLRSGGLHG KGVVGLFKAQ
NAPSPGQSQA DSSSLEQEKY LQAVVSSMPR YADASGRNTL SGFSSAHMGS HGKWGSVRTS
GRSSGLGTEV GSRLAGRDTL APPQANGGPP DPGFLRPQRA ALYILGDKAQ LKGVRPDPLQ
QWELVPIEVF EARQVKASFK KLLKACVPGC PAAEPSPASF LRSLEDSEWL IQIHKLLQVS
VLVVELLDSG SSVLVGLEDG WDITTQVVSL VQLLSDPFYR TLEGFRLLLE KEWLSFGHRF
SHRGAHTLAG QSSGFTPVFL QFLDCVHQVH LQFPMEFEFS QFYLKFLGYH HVSRRFRTFL
LDSDYERIEL GLLYEEKGER RGQLPCRSVW EYVDRLSKRT PVFYNYMYAP EDTEVLRPYS
NVSNLKVWDF YTEETLAEGP PYDWELAQGP PEPPEEERSD GGAPQSRRRV VWPCYDSCPR
AQPDAISRLL EELQRLETEL GRPAERWKDT WDRVKAAQRL EGRPDGRGTP SSLLVSTAPH
HRRSLGVYLQ EGPVGSTLSL SLDSDQSSGS TASGSRQAAR RSTSTLYSQF QTAESENRSY
EGTLYKKGAF MKPWKARWFV LDKTKHQLRY YDHRVDTECK GVIDLAEVEA VAPGTPTMGA
PKTVDEKAFF DVSLGRGLGE GREGLWGVGA AESVTCPSPG EDNASRLQLL CPGRALGPAV
GGPDPELPVG CLSLPALPGC SASSRYRPLG VGRAAPAMFT APALDSIEAP SPQHLCVQPP
SLPRPARPAL TYFGITAEHR AGRWPRYSPQ WACK
//
