UniProt: F7EEF6

Database: UniProt
Entry: F7EEF6_ORNAN

LinkDB:  F7EEF6_ORNAN 
Original site:  F7EEF6_ORNAN

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Ontology (3)   
   GO (3)   
Gene (3)   
   ENSEMBL-UP (3)   
Protein domain (24)   
   InterPro (12)   
   Pfam (5)   
   PROSITE (3)   
   SMART (4)   
All databases (30)   

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ID   F7EEF6_ORNAN            Unreviewed;      1752 AA.
AC   F7EEF6;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 2.
DT   27-MAR-2024, entry version 76.
DE   RecName: Full=Integrin beta {ECO:0000256|RuleBase:RU000633};
GN   Name=ITGB4 {ECO:0000313|Ensembl:ENSOANP00000024980.3};
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000024980.3, ECO:0000313|Proteomes:UP000002279};
RN   [1] {ECO:0000313|Ensembl:ENSOANP00000024980.3}
RP   IDENTIFICATION.
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000024980.3};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC       ECO:0000256|RuleBase:RU000633}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU000633}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC       protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the integrin beta chain family.
CC       {ECO:0000256|ARBA:ARBA00007449, ECO:0000256|RuleBase:RU000633}.
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DR   STRING; 9258.ENSOANP00000024980; -.
DR   Ensembl; ENSOANT00000024984.3; ENSOANP00000024980.3; ENSOANG00000015842.4.
DR   eggNOG; KOG1226; Eukaryota.
DR   GeneTree; ENSGT01100000263555; -.
DR   HOGENOM; CLU_011772_4_0_1; -.
DR   TreeFam; TF105392; -.
DR   Proteomes; UP000002279; Unplaced.
DR   Bgee; ENSOANG00000015842; Expressed in endometrium and 6 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR   CDD; cd00063; FN3; 4.
DR   Gene3D; 2.60.40.2030; -; 1.
DR   Gene3D; 4.10.1240.30; -; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR   Gene3D; 2.10.25.10; Laminin; 3.
DR   Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR   Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR038081; CalX-like_sf.
DR   InterPro; IPR003644; Calx_beta.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR033760; Integrin_beta_N.
DR   InterPro; IPR015812; Integrin_bsu.
DR   InterPro; IPR012896; Integrin_bsu_tail.
DR   InterPro; IPR036349; Integrin_bsu_tail_dom_sf.
DR   InterPro; IPR002369; Integrin_bsu_VWA.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10082; INTEGRIN BETA SUBUNIT; 1.
DR   PANTHER; PTHR10082:SF42; INTEGRIN BETA-4; 1.
DR   Pfam; PF03160; Calx-beta; 1.
DR   Pfam; PF00041; fn3; 4.
DR   Pfam; PF07965; Integrin_B_tail; 1.
DR   Pfam; PF00362; Integrin_beta; 1.
DR   Pfam; PF17205; PSI_integrin; 1.
DR   PRINTS; PR01186; INTEGRINB.
DR   SMART; SM00237; Calx_beta; 1.
DR   SMART; SM00060; FN3; 4.
DR   SMART; SM00187; INB; 1.
DR   SMART; SM01242; Integrin_B_tail; 1.
DR   SUPFAM; SSF141072; CalX-like; 1.
DR   SUPFAM; SSF57196; EGF/Laminin; 2.
DR   SUPFAM; SSF49265; Fibronectin type III; 2.
DR   SUPFAM; SSF69687; Integrin beta tail domain; 1.
DR   SUPFAM; SSF103575; Plexin repeat; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS50853; FN3; 4.
DR   PROSITE; PS00243; INTEGRIN_BETA; 2.
PE   3: Inferred from homology;
KW   Cell adhesion {ECO:0000256|RuleBase:RU000633};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU000633};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000633};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          1085..1174
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          1178..1277
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          1471..1565
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          1585..1681
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   REGION          1361..1381
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1752 AA;  194575 MW;  959988DC5985A91D CRC64;
     PHSPTPTPRL RLVLLQARLP DLESPLRNSP SIPVKNCTEC IRLDKDCAYC TDEEFQGHRC
     NTRVELEDAG CGATSVLTME SSYYILQEKK IDMSLKRSQV SPQRATLRLR PGEERQLQLQ
     VFEPKESPMD LYILMDFSNS MSDDLDNLKN MGQNLAEVLQ EMSDDYTIGF GKFVDKVSVP
     QTDMRPERLR EPWPNSDPPF SFKNVISLTS DLEEFLTKLH GERISGNLDA PEGGFDAILQ
     TAVCKKDIGW RPDSTHLLVF STESAFHYEA DGANVLAGIV KRNDETCHLD ATGTYTHYGG
     QDYPSVPTLV RLLGQNNIIP IFAVTNYSYS YYQKLHKYFP VSAVDELKED SSNIVELLRV
     AFNRIRSQMD IRALDTPRGL KSEVSSKVYK KSEMGSFSIK RGEVGTYEVM LQAVDSVDGK
     HVCQLPEGDR NGVIHFKPSF SDGFYVETSI ICDECSCEKV WAGVPDRSQC PSRSGKTCNC
     STGSLSDTEP CVRDGDTLPC SGRGECQCGN CICYGDGRYE GQFCQFDVFQ CPRASGFLCN
     DRGRCSMGQC VCASGWTGQS CECPLSNATC IDSKGGLCNG RGRCECGRCQ CDHMTPYIDS
     TCEIKHSDGM LLGLCEDLRS CVQCKAWGTG QKKGENCESC SFQVQMVDEL KKGEEVTEYC
     SFRDEEDDCT YSYTVDNDGV PGPNDTVLVH KNKDCPPATF WWLIPLLLLL LLLLPLLLLL
     CWKFCPCCKP LLPPPPGHMV GFKEDHYMLR ENLMASDHLD TPLLRSGNLK SRDTVRWKIN
     NNVQRANLAG HAANANPQDL VLYNLSLRLT RIYTENLLKS DTRESNQLRQ EVEEKVRLRQ
     DLTIVDTAFL APRSAKADLL KLTEKQVDQG SFQDLKVAPG YYTLATDQDA RGMVEFQEGV
     ELVDVRVPLF IRPEDDDDKE LLVEAIDVPE GTATIGRRLV HITIIKEQAT GVVSFERPEY
     TFSRTDQMVR IPVVRRVLDN SRSQVSYRTL DDTAQAQRDY IQVEGELVFQ PGEERKEVHI
     KLLDPRETDS LLRGLPRFRL VLSHPKHGAR LGQLHSTTIF IGESGVRRFL GLPLSSAAQS
     GELGVPQNLT AQASSSRTIL FTWLPPPGTP TGYRVKYWIQ GDSESDAQFV DCSVPSVELS
     NLYPYCDYEM KVCAFGPLGE GPYSHKISCR TSEEVPSEPG RLAFNIVSTT VTQLSWGEPA
     ETNGEITAYE VCYGLVNDDN RPIGPMKKVL VDSPRKRTLL IENLRESQPY RYTVKARNGA
     GWGPEREATI NLATQPKRPM SIPIIPDIPI VDAQDREGND SYLMYSDEVL RSQSGSQRPS
     VSDDTGGSGW QFVPLLGEEL DLRHITWQLP AQLIPRLSGS SCLSSEADGS LPRSVTPGPP
     PEHLANGRLD FMYPGSVHSL NRMVTSSTST YGPHLSPHGP HAVMGSVSTL TTRDYHSLTR
     TEHSSTLPRD YSTLTSVTSH ESRLAPGLPD TPTRLVFSAL GPTSLKVSWQ EPQCEQELRG
     YRVEYQLLGG GEVLQELLIN NPAQTSIVVE DLVPNHSYIF RVQAQSQEGW GPEREGVITI
     ESQVLPHSPL CPMPGSPFTL STPSAPGPLV FTALSPDSLQ LSWQRPRRPN GDILGYLVTC
     EMARQGGSSK TFQVEGDQAE MRLTVPGLSE NVPYKFKVQA KTTQGFGPER EGVITIESQD
     GGPFTQLGGQ QTLCQELCTL PGEFSTNGLT LGPLGLEAGG TLTRQVTQEF VSRTLTSSGT
     LTKQTERQFY QA
//

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