ID   F7EEJ8_ORNAN            Unreviewed;       795 AA.
AC   F7EEJ8;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 2.
DT   27-MAR-2024, entry version 65.
DE   SubName: Full=Nuclear GTPase, germinal center associated {ECO:0000313|Ensembl:ENSOANP00000024971.2};
GN   Name=NUGGC {ECO:0000313|Ensembl:ENSOANP00000024971.2};
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000024971.2, ECO:0000313|Proteomes:UP000002279};
RN   [1] {ECO:0000313|Ensembl:ENSOANP00000024971.2}
RP   IDENTIFICATION.
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000024971.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_001509019.2; XM_001508969.3.
DR   AlphaFoldDB; F7EEJ8; -.
DR   STRING; 9258.ENSOANP00000024971; -.
DR   Ensembl; ENSOANT00000024975.2; ENSOANP00000024971.2; ENSOANG00000015837.3.
DR   GeneID; 100077883; -.
DR   KEGG; oaa:100077883; -.
DR   CTD; 389643; -.
DR   eggNOG; ENOG502QVUX; Eukaryota.
DR   GeneTree; ENSGT00390000007091; -.
DR   HOGENOM; CLU_019456_0_0_1; -.
DR   InParanoid; F7EEJ8; -.
DR   OMA; IEQCFAH; -.
DR   OrthoDB; 3604509at2759; -.
DR   TreeFam; TF352086; -.
DR   Proteomes; UP000002279; Unplaced.
DR   Bgee; ENSOANG00000015837; Expressed in adult mammalian kidney and 2 other cell types or tissues.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR   GO; GO:0033262; P:regulation of nuclear cell cycle DNA replication; IEA:Ensembl.
DR   CDD; cd00882; Ras_like_GTPase; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR045063; Dynamin_N.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR47308; NUCLEAR GTPASE SLIP-GC; 1.
DR   PANTHER; PTHR47308:SF1; NUCLEAR GTPASE SLIP-GC; 1.
DR   Pfam; PF00350; Dynamin_N; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002279}.
FT   DOMAIN          103..324
FT                   /note="Dynamin N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00350"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        14..28
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   795 AA;  90757 MW;  B8E8BAE5A653F3E7 CRC64;
     MEYPMADAEV FVDQESPSAK EEPGKKRRRS GSHLKFRAFP SAEQSALKEY EKLESRTRRV
     LSTTYQKIIQ SVFFEDGIPS GVKYLINRLL TLIEKPSLEP VYIGLFGSTG AGKSSLLNAI
     INEKMFLPVS GESTCTSCLV QVSSGVSDKY EAKIHLLSDQ EWKEELRNLT ELLDKREEGQ
     GSEENDWGDD SDIAEEAVQK LQMLYGRGAE NKSYEELLRT KLREKIPTSK IITLKGEEAS
     ELSAQLDSYI RIQTGDADGQ SSEPQIQPLI KYVEVTLPNS EVIPEGVVLV DIPGTGDFNS
     ERDDIWKKTI NKCSVIWVIS DIERVSGGKA HEVLLKESLK ACQRGVCTDI SLVVTKADKL
     YLPEYLRERK DGKQTIGTQR EAILERNGAV KLQRSRILKE KLKRKLPSSS MILDAPDLVY
     TVSAQEYWQQ ELLSEEETEI PKLREYVRKR FLREKRRTVT EYVAEAFGIL LLMDNFNSKE
     NFMEDYFHPS GLKRFVEERV TVLEKDVDQC FAQMEQPLQE GVRSAKLSYR RILSGRLTRS
     KGNQGFHQTL KAVCLKNGIF ASRTLARIDL NEDITQPIYD KIDPIFGSIF RTGKDNHAGL
     LPHLDAFKLS LHERIRNAGL RSDWKSDSYK QRLLSQEVNV MLGALEGHVL RKKRCIYESV
     YISIQNELKY CYEEAAQVTG KKACERMKDI IKRGVERQVA EGMFERAQSR MQEQFQELKS
     GIMEKMKMRI STMLALASSK TEGLYIELPD VKTEYKEMEK LYKSLREIAE NAVLRKGLQD
     FLIRMSPSKV GPAKS
//