ID F7EHI9_ORNAN Unreviewed; 118 AA.
AC F7EHI9;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=D-dopachrome decarboxylase {ECO:0000256|ARBA:ARBA00038884};
DE EC=4.1.1.84 {ECO:0000256|ARBA:ARBA00038884};
GN Name=DDT {ECO:0000313|Ensembl:ENSOANP00000011041.3};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000011041.3, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000011041.3}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000011041.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Tautomerization of D-dopachrome with decarboxylation to give
CC 5,6-dihydroxyindole (DHI). {ECO:0000256|ARBA:ARBA00037460}.
CC -!- SUBUNIT: Homotrimer. {ECO:0000256|ARBA:ARBA00011233}.
CC -!- SIMILARITY: Belongs to the MIF family. {ECO:0000256|ARBA:ARBA00005851}.
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DR AlphaFoldDB; F7EHI9; -.
DR STRING; 9258.ENSOANP00000011041; -.
DR Ensembl; ENSOANT00000011043.3; ENSOANP00000011041.3; ENSOANG00000006930.3.
DR eggNOG; KOG1759; Eukaryota.
DR GeneTree; ENSGT00940000156821; -.
DR HOGENOM; CLU_129906_2_1_1; -.
DR InParanoid; F7EHI9; -.
DR OMA; PDRINIR; -.
DR TreeFam; TF313853; -.
DR Proteomes; UP000002279; Unplaced.
DR Bgee; ENSOANG00000006930; Expressed in liver and 8 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0050178; F:phenylpyruvate tautomerase activity; IBA:GO_Central.
DR GO; GO:0042438; P:melanin biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 3.30.429.10; Macrophage Migration Inhibitory Factor; 1.
DR InterPro; IPR001398; Macrophage_inhib_fac.
DR InterPro; IPR019829; Macrophage_inhib_fac_CS.
DR InterPro; IPR014347; Tautomerase/MIF_sf.
DR PANTHER; PTHR11954; D-DOPACHROME DECARBOXYLASE; 1.
DR PANTHER; PTHR11954:SF22; D-DOPACHROME DECARBOXYLASE; 1.
DR Pfam; PF01187; MIF; 1.
DR SUPFAM; SSF55331; Tautomerase/MIF; 1.
DR PROSITE; PS01158; MIF; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Melanin biosynthesis {ECO:0000256|ARBA:ARBA00023101};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279}.
SQ SEQUENCE 118 AA; 12640 MW; E85FD32FE55B0CAA CRC64;
MPFVELDTSL AAARLPPDLA SRLCAAAAAI LAKPEDRVNV TVRPGLGMVL SGSAEPCAQL
LVSSIGVVGT AEQNRGHSAK FFDFLTKELG LSPDRINIRF YPLEPWQIGK KGTVMTFL
//
