ID F7EMV4_MONDO Unreviewed; 945 AA.
AC F7EMV4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=PHD finger protein 20 {ECO:0000313|Ensembl:ENSMODP00000001866.4};
GN Name=PHF20 {ECO:0000313|Ensembl:ENSMODP00000001866.4};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000001866.4, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000001866.4, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000001866.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F7EMV4; -.
DR STRING; 13616.ENSMODP00000001866; -.
DR Ensembl; ENSMODT00000001906.4; ENSMODP00000001866.4; ENSMODG00000001533.4.
DR eggNOG; KOG1844; Eukaryota.
DR GeneTree; ENSGT00940000156477; -.
DR HOGENOM; CLU_012707_0_0_1; -.
DR InParanoid; F7EMV4; -.
DR OMA; IRAIWIK; -.
DR TreeFam; TF106475; -.
DR Proteomes; UP000002280; Chromosome 1.
DR Bgee; ENSMODG00000001533; Expressed in skeleton of lower jaw and 19 other cell types or tissues.
DR ExpressionAtlas; F7EMV4; baseline.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0071339; C:MLL1 complex; IBA:GO_Central.
DR GO; GO:0044545; C:NSL complex; IBA:GO_Central.
DR GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0051571; P:positive regulation of histone H3-K4 methylation; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd20104; MBT_PHF20L1-like; 1.
DR CDD; cd20453; Tudor_PHF20; 1.
DR Gene3D; 2.30.30.140; -; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR041297; Crb2_Tudor.
DR InterPro; IPR043449; PHF20-like.
DR InterPro; IPR022255; PHF20_AT-hook.
DR InterPro; IPR002999; Tudor.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR15856:SF27; PHD FINGER PROTEIN 20; 1.
DR PANTHER; PTHR15856; PHD FINGER PROTEIN 20-RELATED; 1.
DR Pfam; PF20826; PHD_5; 1.
DR Pfam; PF12618; PHF20_AT-hook; 1.
DR Pfam; PF18115; Tudor_3; 1.
DR SMART; SM00249; PHD; 1.
DR SMART; SM00333; TUDOR; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 2.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 390..420
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 171..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 421..464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 479..561
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..205
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..221
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 224..271
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 432..455
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 513..536
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..551
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 945 AA; 109235 MW; AD2C87173ADADBD6 CRC64;
MTKHPPNRRG ISFEVGAQLE ARDRLKNWYP AHIQEIDYEE GQVLIHFKRW NHRYDEWFCW
DSPYLRPLEK IQLRKEGLHD EEGSFEFHIN EQVLACWSDC RFYPAKVTAV NKDGTYTVKF
YDGVIQTVKH IHVKAFSKDQ VRKFCSLVFL ISSFFFLSPL DKENISDYDR EYSGETQADK
KPENDIVKNT QENLREPKRK RGRPPSIPQS EPNSQTLQPI TLELRRRKIS KGAEIRLKRP
KLEKNSSQEK SKAYPENNDK DLTRRRSSRL SNSGSHEILD ADLVISNVID TAPSEDTLPL
AKELEEGQLE SSVRSDKSSS ELRNRSFVDE LKTAVFDLNC DSMEDKAVDS ELASPLAELK
EISAVTATNA IKRDEFVTSK FPTIDLDHKF RCTFVDCLKF FRKAKLLHYH MKYFHGIEKT
PEPEENSVKR HVQTRGSLAS EKASQDGLTR KRITSSSLSV KDKEKNKEKK FREFVRLKSK
KKKKKKKKSK PEYSCSEDAS DASQECSPPK PFAVTRCSSS NKSGTPLSTS VHISDSGNHQ
ERGKIPEDDN VSDSSSESFL WSDEDCSHDI DVTTNPDDDP DGEDNFDFEI VRCICEVQEE
NDFMIQCEEC QCWQHGVCMG LLEDNVPEKY ICYICQDPPG QRPGVKYWYE KEWLSHGHMH
GLAFLEDNYS HQNAKKIVAT HQLLGDVQKV IEVLHGLQLK MRILQSKEHP DLQLWCQPWK
QHSGDEKSHP KHALHIEDKR KEDMPSYRTF SGTVEKTLPF RSMEESYITS EHCYQKPRAY
YPAVEQKLVV ETRGSAMDDS VNPIRENGDD VLSERFGWEL EQEKIKIQNE LRNTYSKVRE
CASKKALSEE APTLKLLEKD REGVVNAQLQ WQFNLLTHVE SLQDEVTHRM DSIEKELDVL
ESWLDYTGEL EPPEPLARLP QLKHCIKQLL TDLGKVQQIA LCCST
//
