ID F7EN86_MACMU Unreviewed; 541 AA.
AC F7EN86; F7EMW2;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Centrosomal protein of 63 kDa {ECO:0000256|ARBA:ARBA00021306};
GN Name=CEP63 {ECO:0000313|EMBL:AFH34110.1,
GN ECO:0000313|Ensembl:ENSMMUP00000016758.3,
GN ECO:0000313|VGNC:VGNC:71104};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000016758.3, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|EMBL:AFH34110.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Thymus {ECO:0000313|EMBL:AFH34110.1};
RX PubMed=25319552; DOI=10.1186/1745-6150-9-20;
RA Zimin A.V., Cornish A.S., Maudhoo M.D., Gibbs R.M., Zhang X., Pandey S.,
RA Meehan D.T., Wipfler K., Bosinger S.E., Johnson Z.P., Tharp G.K.,
RA Marcais G., Roberts M., Ferguson B., Fox H.S., Treangen T., Salzberg S.L.,
RA Yorke J.A., Norgren R.B.Jr.;
RT "A new rhesus macaque assembly and annotation for next-generation
RT sequencing analyses.";
RL Biol. Direct 9:20-20(2014).
RN [3] {ECO:0000313|Ensembl:ENSMMUP00000016758.3}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000016758.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome, centriolar satellite
CC {ECO:0000256|ARBA:ARBA00004607}.
CC -!- SIMILARITY: Belongs to the CEP63 family.
CC {ECO:0000256|ARBA:ARBA00007181}.
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DR EMBL; JU477306; AFH34110.1; -; mRNA.
DR RefSeq; XP_002803042.1; XM_002802996.2.
DR RefSeq; XP_014987592.1; XM_015132106.1.
DR Ensembl; ENSMMUT00000017896.4; ENSMMUP00000016758.3; ENSMMUG00000012752.4.
DR GeneID; 717266; -.
DR CTD; 80254; -.
DR VEuPathDB; HostDB:ENSMMUG00000012752; -.
DR VGNC; VGNC:71104; CEP63.
DR eggNOG; ENOG502QRYU; Eukaryota.
DR GeneTree; ENSGT00940000153190; -.
DR HOGENOM; CLU_027471_0_0_1; -.
DR OrthoDB; 5403090at2759; -.
DR TreeFam; TF330595; -.
DR Proteomes; UP000006718; Chromosome 2.
DR Bgee; ENSMMUG00000012752; Expressed in spermatid and 23 other cell types or tissues.
DR GO; GO:0034451; C:centriolar satellite; IEA:UniProtKB-SubCell.
DR Gene3D; 1.20.5.340; -; 1.
DR InterPro; IPR031470; Cep63/Deup1_N.
DR PANTHER; PTHR18875:SF7; CENTROSOMAL PROTEIN OF 63 KDA; 1.
DR PANTHER; PTHR18875; SARCOMA ANTIGEN NY-SAR-24/CYTOSKELETAL PROTEIN SOJO; 1.
DR Pfam; PF17045; CEP63; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718}.
FT DOMAIN 18..280
FT /note="Centrosomal protein Cep63/Deup1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF17045"
FT COILED 82..187
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 244..296
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 350..405
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 442..479
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 541 AA; 63174 MW; 1C9068A28329B2DF CRC64;
MEALLERMQN RGHGGGFLTS CEAELQELMK QIDIMVAHKK SEWEGRTHAL ETCLKIREQE
LKTLRGQLDV THKEVGMLHQ QVEEHEKIKQ EMTMEYKQEL KKLHEELGIL KRSYEKLQKK
QMREFRGNTK NHREDRSEIE RLTAKIEEFR QKSLDWEKQR LIYQQQVSSL EAQRKALAEQ
SEIIQAQLAN RKQKLESVEL SSQSEIQHLS SKLERANDTI CANELEIERL TMRVNDLVGT
SMTVLQEQQQ KEEKLRESEK LLEALQEEKR ELRAALQSQE NLIHEGRMQK EKLQEKVKAT
DTQHAVEAIR LREESLAEKK YTSQGQGDLD SVLSQLNFTH TSEELLQAEV TRLEGSLESV
SATCKQLSQE LMEKYEELKR MEAHNNEYRA EIKKLKEQIL QGEQSYSSAL EGMKMEISHL
TQELHQRDIS IASTKGSSSD MEKRLKAEIQ KAEEKAVEHK EILDQLESLK LENRHLSEMV
MKFELGLHEC SLPVSPLGSI ATRFLEEEEL RSHHILERLD AHIEELKRES EKTVRQFTAL
K
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