ID F7EPK1_MONDO Unreviewed; 992 AA.
AC F7EPK1;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=WD repeat domain 59 {ECO:0000313|Ensembl:ENSMODP00000018320.2};
GN Name=WDR59 {ECO:0000313|Ensembl:ENSMODP00000018320.2};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000018320.2, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000018320.2, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000018320.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the WD repeat WDR59 family.
CC {ECO:0000256|ARBA:ARBA00038452}.
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DR RefSeq; XP_007477565.1; XM_007477503.2.
DR AlphaFoldDB; F7EPK1; -.
DR Ensembl; ENSMODT00000018653.2; ENSMODP00000018320.2; ENSMODG00000014658.3.
DR GeneID; 100023794; -.
DR KEGG; mdo:100023794; -.
DR CTD; 79726; -.
DR GeneTree; ENSGT00940000157600; -.
DR OrthoDB; 23438at2759; -.
DR Proteomes; UP000002280; Chromosome 1.
DR Bgee; ENSMODG00000014658; Expressed in cerebellum and 17 other cell types or tissues.
DR ExpressionAtlas; F7EPK1; baseline.
DR CDD; cd16692; mRING-H2-C3H3C2_WDR59; 1.
DR Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR006575; RWD_dom.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR049567; WDR59-like.
DR InterPro; IPR039456; WDR59_mRING-H2-C3H3C2.
DR InterPro; IPR049566; WDR59_RTC1-like_RING_Znf.
DR PANTHER; PTHR46170; GATOR COMPLEX PROTEIN WDR59; 1.
DR PANTHER; PTHR46170:SF1; GATOR COMPLEX PROTEIN WDR59; 1.
DR Pfam; PF00400; WD40; 3.
DR Pfam; PF17120; zf-RING_16; 1.
DR SMART; SM00591; RWD; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF54495; UBC-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50908; RWD; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 101..143
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 187..229
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 393..494
FT /note="RWD"
FT /evidence="ECO:0000259|PROSITE:PS50908"
FT REGION 348..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 820..870
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..371
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 849..869
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 992 AA; 111804 MW; A70D9E10A4C59807 CRC64;
MAARWSSENV VVEFRDSQAT AMSVDCLGQH AVLSGRRFLY IVNLDAPSEG HRKISRQSKW
DIGAVQWNPH DSYAHYFAAS SNQRVDLYKW KDGSGEVGTA LQGHTRVISD LDWAVFEPDL
LVTSSVDTYI YIWDIKDTRK PTVALSAVAG ASQVKWNKKN AHCLATSHDG DVRIWDKRKP
STAVEYLAAH LSKIHGLDWH PDSEHILATS SQDNSVKFWD YRQPRKYLNI LPCQVPVWKA
RYTPFSNGLV TVMVPQLRRE NSLLLWNVFD LNTPVHTFVG HDDVVLEFQW RKQKEGSKDY
QLVTWSRDQT LRMWRVDSQL QRLCANDILD GVDEFIESIS LLPEPEKTLH TQDSDHQPNL
SHGEEEASKE DPPNNILLGK KSEQLGLPQT LQQEFSLINV QIRNVNVEMD AVDRSCTVSV
HCSNHRVKML VKFPAQYPNN AAPSFQFINP TTITSTMKAK LLKILKDTSL QKVKRNQSCL
EPCLRQLVSC LESFVNQEDS TSSNPFALPN AVTPPLPTFA RVTSAYGSYQ DANIPFPRTS
GARFCGAGYL VYFTRPMTMH RAVSPTEPTP RSLSALSAYH SGLITPMKIR TEAPGNLRLY
SGSPTRNEKD QVSISSFYYK ERMSPRSARR RWSIQAINDF PKSRRWKSKR EGSDSGNRPI
KAAGKVIIQD IACLLPVHKS LGELYILNIN DIQETCQKNA SSALLVGRKD LVQVWSLATV
ATDLCLGPKS DPDLETPWAR HPFGRQLLES LLAHYCQLRD VQTLAMLCSV FEAQSRPQGI
LNPFGPFPNR SSNLVSHSRY PSFTSSGSCS SMSDPGLSTG GWNIVGRDTE HASSPWGESS
PDELRFGSLT YSDPRERERD QHDKNKRLLD PANTQQFDDF KKCYGEILYR WGLREKRAEV
LKFVSCPPDP HKGIEFGVYC SHCRSEVRGT QCAICKGFTF QCAICHVAVR GSSNFCLTCG
HGGHTSHMME WFRTQEVCPT GCGCHCLLES TF
//
