ID F7ES41_CALJA Unreviewed; 2623 AA.
AC F7ES41;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Telomerase associated protein 1 {ECO:0000313|Ensembl:ENSCJAP00000018119.4};
GN Name=TEP1 {ECO:0000313|Ensembl:ENSCJAP00000018119.4};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000018119.4, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000018119.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000018119.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 9483.ENSCJAP00000018119; -.
DR Ensembl; ENSCJAT00000019149.4; ENSCJAP00000018119.4; ENSCJAG00000009781.4.
DR eggNOG; KOG3602; Eukaryota.
DR eggNOG; KOG4155; Eukaryota.
DR GeneTree; ENSGT00940000161338; -.
DR InParanoid; F7ES41; -.
DR OMA; WQILPKG; -.
DR TreeFam; TF328424; -.
DR Proteomes; UP000008225; Chromosome 10.
DR Bgee; ENSCJAG00000009781; Expressed in kidney and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0016363; C:nuclear matrix; IEA:Ensembl.
DR GO; GO:0005697; C:telomerase holoenzyme complex; IEA:Ensembl.
DR GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR GO; GO:0002039; F:p53 binding; IEA:Ensembl.
DR GO; GO:0003720; F:telomerase activity; IEA:Ensembl.
DR GO; GO:0070034; F:telomerase RNA binding; IEA:Ensembl.
DR GO; GO:0000722; P:telomere maintenance via recombination; IEA:Ensembl.
DR CDD; cd00200; WD40; 2.
DR Gene3D; 1.25.40.370; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 6.
DR InterPro; IPR025139; DUF4062.
DR InterPro; IPR045804; DUF5920.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008850; TEP1_N.
DR InterPro; IPR008858; TROVE_dom.
DR InterPro; IPR037214; TROVE_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR44791:SF1; TELOMERASE PROTEIN COMPONENT 1; 1.
DR PANTHER; PTHR44791; TELOMERASE PROTEIN COMPONENT 1 TEP1; 1.
DR Pfam; PF13271; DUF4062; 1.
DR Pfam; PF19334; DUF5920; 1.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF05386; TEP1_N; 4.
DR Pfam; PF05731; TROVE; 1.
DR Pfam; PF00400; WD40; 10.
DR SMART; SM00320; WD40; 17.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF140864; TROVE domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 3.
DR PROSITE; PS50837; NACHT; 1.
DR PROSITE; PS51226; TEP1_N; 4.
DR PROSITE; PS50988; TROVE; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 10.
DR PROSITE; PS50294; WD_REPEATS_REGION; 4.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 225..678
FT /note="TROVE"
FT /evidence="ECO:0000259|PROSITE:PS50988"
FT DOMAIN 1164..1432
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT REPEAT 1757..1798
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1840..1881
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1882..1914
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 2010..2039
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 2059..2100
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 2105..2145
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 2146..2176
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 2236..2269
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 2278..2310
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 2547..2577
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 2511..2546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2623 AA; 290417 MW; 40DAB094210F1C01 CRC64;
MEKLHGHVSA DPDILSLENR CLAMLPDLHP MEKLHEHISP HSDILSLKNQ CLAMLPDLKT
MEKPHGHVSA HPDILSLENR CLATLPNLKT LEKPHGHVSA HPDILSLENR CLATLPSLKS
TVSANPLLQN LQISYMMQAD LYRVNSSNCL LSEPPSCRAQ HFSKGPGLSA CPMAPVSATE
TVQEATLGHW FYSEEKKPEE KKVAETQIPS YSLSLGEEEV EDLAVKLTSG DCESHLEPTD
QVLQEKKMAL MSLLCSTLVS EVNMKNASDP ILAEIFEVCS EVAPLEPEFI LKASLYARQQ
LNVRNVANKV LAIAAFLPAC RPHLRRYFCA IVQLPSDWIQ VAELYQSLAG GDENKLVPLP
ACLRTAMMDK FAQFDEYQLA KYNPWNHRAK RHPRRPARSP RMEPPFSSRR FPRYIIFLRD
EQRKFEKACD AESEKKNPPR FTLKKLVQRL HIHEPAQHVQ ALLGYRYPSN LQLFSRSRLP
GPWDSSRAGK RMKLSRPETW DRELSLRGNK ASVWEELIEN EKLPFMAMLR NLCNLLRVGI
SARHHELVLQ RLQHAKSVIH SRQFPFRFLN AHDSIDALEA QLRNQALPFP SNITLMRQII
TRNEKNCPRR RFLCSLSRQQ LRAVMRIPVM YEQLKREKLR VHKARQWKYD GEMLNRYRQA
LETAVNLSVK HSLPPLPGRT ILVYLTDANA DKLCPKSNPK GPPLNYVLLL IGMMITTAEQ
VDVVLCGGDT LKTAVLKPEE GILKTAIKLQ AQVQEFDEKN EWSLNTFGKY LLSLAGQRVP
VDRVILFGQS MDYGMINVAK QLYWQRVNSK CLFVGILLRR VQYLSTDLNP NDVTLSGCTD
GILKFIAEHG ASHLLEHVGQ MDKIFKIPPH PGKTGIQTLR PLEEDTPSPL APISQQGWRS
IRLFISSTFR DMHGERDLLL RSVLPALQAR AAPHHISLHG IDLRWGVTEE ETRRNRQLEV
CLGEVENAQL FVGILGSRYG YVPPSYNLPD HPHFHWAQQY PSGRSVTEME VMQFLNRNQR
LQPSAQALIY FRDSSFLSSV PGAWKSDFVS ESEEAACRIS ELKSYLSRQK GITCRRYPCE
WGGVAAGQPY VGGLEEFGQL VLQDVWNMIQ KLYLQPGALL EQPVSIPDDD LVQDTFQQLQ
KPPSPARLRL LQDTVQQLMM QHGRLSLVTG QSGQGKTAFL ASLVSALQAA DGAKVAPLVF
FHFSGARPDQ GLALTLLRRL CTYLHGQLKD PNALPNTYRS LVWELQQRLL PKSAESLQPG
QTLVLIIDGA DRLVDQNGQL ISDWIPKKLP RCVHLVLSVS SDVGLGETLE QSQGAHVVAL
GPLEASARAR LVREELALYG KRLEESPFNN QMQLLLVKRE SGRPLYLRLV TDHLRLFTLY
EQVSERLRSL PATVPLLLQH ILSTLEQEHG PDVLPQALTT LEVTRSGLTV DQLHGVLSVW
RTLPKGTNSW EEAVAAGNSG DPYPMGPFAY LVQSLRSLLG EGPLERPGAR LCLPDGPLRT
AAKRRYAKRP GLEDTAHILI AAQLWKTCDA DASGTFRSCP PEALGDLPYH LLQSRNVGLL
SKFLTNLHVV AAHLELGLVS RLLEAHALYA SSVPTAEQKL PEADVAVFRT FLRQQASILS
QYPRLLPQQA ANQPLDSPLY RQAPLLSQRW HLQHTLRWLN KPQTMKNQQS SSLSLAVSSS
PTAVAFSTNG HRAAVGTANG TVYLLNLRTW QEEKSMVSGC DGISACLFLS DDTLFLTAFD
GLLELWDLQH GCRVLQTKAH QYQITGCCLS PDRRLLATVC LGGCLKLWDT GRGQLAFQHT
YPKSLNCVAF HPEGQVVATG SWAGSISFFQ VDGLKLTKDL GASGASVRTL AFNVPGRVVA
VGRLDSMVEL WSWREGARLA AFPAHHGFVA AALFLHAGCQ LLTAGEDGKV QVWSGSLGRP
RGYLGSLSLS PALSVALSPD GDQVAVGYRA DGIKIYKISS GSQGAQGQAL DVAVSALAWL
NSRVLVSGAE DGSLQGWALK ECYLQSLWLL STHQKPVLGL ATSQQLLASA SEDFTVWLWP
RQLLTLPHKA EDFPCGTELR GHEGPVSCCS FSTDGGSLAT GGRDRGLLCW DVRTPKAPVL
IRSFPACHRD WVTGCAWTKD NLLISCSSDG SVGLWDPESG QQLGQFLGHQ SAVSAVAAVG
EHVVSVGRDG TLKVWDHQGV ELTSIPAHSG PISHCAAALE PQAAGQPGSE LLVVTIGLDG
ATRLWHPLLV CQTHTLLGHS GPVRAAAVSE TSGLLLTASE DGSVRLWQVP KEADDTCIPR
SSAAITAVAW APDGSMAASG NQAGKLILWQ EAKAVATAQA PGHIGALIWS STHTFFALSA
DEKISEWQVK LRQGSAPGNF SLHLNRILQE DLGVLTSLGW APDGHFLILA KADLKLLCMK
PGDAPSEIWS SYTENPMILS THKEYGIFVL QPKDPGVLSF LRQKESGEFE ESLNFNINLE
NPSRTLISIT QAKPESESSF LCASSDGMLW NLAKCNPEGE WTTGNIWQKE VNTPETATPE
TDQSTRRESD ASMHSEPIPH LNTRQRRKIH SGSVTALHVL PELLVTASKD RDVKIWERPS
MQLLGLFQCE GSVSCLEPWL GTNSTLQLAV GDMQGNVYFL SWE
//
