ID F7ESD0_CALJA Unreviewed; 1781 AA.
AC F7ESD0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 4.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN Name=SCN11A {ECO:0000313|Ensembl:ENSCJAP00000018110.5};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000018110.5, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000018110.5}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000018110.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR STRING; 9483.ENSCJAP00000018110; -.
DR Ensembl; ENSCJAT00000019140.5; ENSCJAP00000018110.5; ENSCJAG00000009856.5.
DR eggNOG; KOG2301; Eukaryota.
DR GeneTree; ENSGT00940000161553; -.
DR HOGENOM; CLU_000540_5_0_1; -.
DR InParanoid; F7ESD0; -.
DR OMA; VEIDMFP; -.
DR TreeFam; TF323985; -.
DR Proteomes; UP000008225; Chromosome 17.
DR Bgee; ENSCJAG00000009856; Expressed in heart.
DR GO; GO:0044295; C:axonal growth cone; IEA:Ensembl.
DR GO; GO:0044299; C:C-fiber; IEA:Ensembl.
DR GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:Ensembl.
DR GO; GO:0099610; P:action potential initiation; IEA:Ensembl.
DR GO; GO:0002526; P:acute inflammatory response; IEA:Ensembl.
DR GO; GO:0060840; P:artery development; IEA:Ensembl.
DR GO; GO:0007409; P:axonogenesis; IEA:Ensembl.
DR GO; GO:0061367; P:behavioral response to acetic acid induced pain; IEA:Ensembl.
DR GO; GO:0061368; P:behavioral response to formalin induced pain; IEA:Ensembl.
DR GO; GO:1990408; P:calcitonin gene-related peptide receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0070588; P:calcium ion transmembrane transport; IEA:Ensembl.
DR GO; GO:0048870; P:cell motility; IEA:Ensembl.
DR GO; GO:0070417; P:cellular response to cold; IEA:Ensembl.
DR GO; GO:0002544; P:chronic inflammatory response; IEA:Ensembl.
DR GO; GO:0007623; P:circadian rhythm; IEA:Ensembl.
DR GO; GO:0050966; P:detection of mechanical stimulus involved in sensory perception of pain; IEA:Ensembl.
DR GO; GO:0050965; P:detection of temperature stimulus involved in sensory perception of pain; IEA:Ensembl.
DR GO; GO:0043303; P:mast cell degranulation; IEA:Ensembl.
DR GO; GO:0086010; P:membrane depolarization during action potential; IEA:Ensembl.
DR GO; GO:0060073; P:micturition; IEA:Ensembl.
DR GO; GO:0019228; P:neuronal action potential; IEA:Ensembl.
DR GO; GO:0010737; P:protein kinase A signaling; IEA:Ensembl.
DR GO; GO:0060004; P:reflex; IEA:Ensembl.
DR GO; GO:0010996; P:response to auditory stimulus; IEA:Ensembl.
DR GO; GO:0009408; P:response to heat; IEA:Ensembl.
DR GO; GO:0009644; P:response to high light intensity; IEA:Ensembl.
DR GO; GO:0071731; P:response to nitric oxide; IEA:Ensembl.
DR GO; GO:0034695; P:response to prostaglandin E; IEA:Ensembl.
DR GO; GO:0009636; P:response to toxic substance; IEA:Ensembl.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl.
DR GO; GO:0160025; P:sensory perception of itch; IEA:Ensembl.
DR GO; GO:0060538; P:skeletal muscle organ development; IEA:Ensembl.
DR GO; GO:1990770; P:small intestine smooth muscle contraction; IEA:Ensembl.
DR GO; GO:0040040; P:thermosensory behavior; IEA:Ensembl.
DR GO; GO:0001966; P:thigmotaxis; IEA:Ensembl.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF210; SODIUM CHANNEL PROTEIN TYPE 11 SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR PRINTS; PR00170; NACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU361132};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 131..150
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 162..185
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 197..217
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 251..273
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 371..390
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 576..594
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 606..627
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 696..721
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 780..807
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1052..1071
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1114..1136
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1162..1195
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1281..1304
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1354..1377
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1397..1415
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1427..1446
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1482..1510
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1530..1553
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1574..1600
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 128..407
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 575..816
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 823..1047
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 1052..1313
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1362..1610
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 468..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 405..432
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1781 AA; 203127 MW; 2AB80000225FA1F5 CRC64;
MDDRCYPVIF PDERNFRPFT SDSLAAIEKR IAIQKEKKKS KDQTGEVPQP RPQLDLKVSR
KLPKLYGNIP QDLIGKPLED LDPFYRDHKT FMVLNKKRTI YRFSAKRALF IFGPFNSIRS
LAIRVSVHSL FSMFIISTVI INCVFMASGL GKTSNSNDTD IAEYVFTGIY IFEALIKILA
RGFILDEFSF LRDPWNWLDS LVIGTAMVSL GISINLLSLR TFRVLRALKA ISVVSRLKVI
VGALLRSVKK LINVIILTLF CLSIFALVGQ QLFMGSLNLK CVRSDCKNVS NQEACDYCFE
KKENSTEFRM CGTWMGNSSC SSQYECIHTR INPDYNYTNF DNFGWSFLAM FRLMTQDSWE
KLYQQTLRTT GLYSVFFFIV VIFLGSFYLI NLTLAVVTMA YEEQNRNVAA EIEAKEKMFQ
EAQQLLREEK EALVAMGIDR SSLTSLETSH FSPQKRKLFG NKKRKSFFMR EPGKDQPPGS
DSDEDSQKTP QLLEQTKRLS HNLSLDHFDE HGDPLQRQRA LSAVSILTIT MKEQEKSQEP
CLPCGENLAS KYLVWNCCPQ WVAIKKVLRI VMTDPFTELA ITICIIINTV FLAMEHHKME
ASFEKMLNTG NLVFTSIFLA EMCLKIIALD PYHYFRRGWN VFDSIVALLS FADVLNGIFQ
KRSWPFLRSF RVLRVFKLAK SWPTLNTLIK IIGNSVGALG SLTVVLAIVI FIFSVAGMQL
FGSSFNSLKS AKLCDPTDPT VSCLRHWHMG DFWHSFLVVF RILCGEWIEN MWECMQEANT
SLCVIVFVLI TVIGKLVVLN LFIALLLNSF SNEERNGSVE GEARKTKVQL ALDRFHWAFC
FVIHTLEHFF HKWCWKQKSP KQKEVTGGCA AQSKDFIPLV RETKRGSETQ EELGIQASVP
KTLGVGHDRT WLAPLAEEED DVEFSGGDNA QPITQSEAEQ QACELHQETK KPISQRVRSV
EIDMLSEDEP HLTVQNPRKK SDATSMLSEC STIDLQDAFG WLPEMVPKKE PERCLPKGLG
CCLPCCNIDK RKSPWVVWWN LRKTCYQIVK HGWFESFIIF VILLSSGALI FEDVHLEGRP
KIQELLNCTD FIFTHIFILE MLLKWVAFGF GKYFTSAWCC LDFIIVIVSV TSLINLKELK
SFRTLRALRP LRALSQFEGM KVVVNALIGA IPAILNVLLV CLIFWLIFCI LGVYFFSGKF
WRCINGTDSV INYTIVPNKN QCESGNFSWL NQKVNFDDVG NAYLALLQVA TFKGWMDIIR
AAVDSRGKEQ QPAFESSSLS YLYFVVFIIF GSFFTLNLFI GVIIDNFNQQ QKKLGGQDIF
MTEEQKKYYN AMKKLGSKKP LKPIPRPLNK CQGLVFDIVT SQIFDIVIII LIILNMITMM
AESYNQLRAT ESALDRLNWT FVAVFTVECL IKIFALRQHY FTNGWNLFDC VVVVLSIVST
IVSILAKQDH IPFPPTLFRI VRLARIGRIL RLVRAARGIR TLLFALMMSL PSLFNIGLLL
FLVMFIYAIL GMNWFSKVNP ESGIDDIFNF QTFASSMLCL FQITTSAGWD ALLSPMLRSK
ESCNSSSENC HLPGIATSYF VSYIIISFLI VVNMYIAVIL ENFNTATEES EDPLGEDDFD
IFYEVWEKFD PEATQFIKYS ALSDFADALP EPLRVAKPNK YQFLVMDLPM VSGDRLHCLD
ILFAFTTNVL GGSDGLDSMK TMMEEKFMEA NPFKKLYEPI VTTTKRKEEE RCAAVIQKAF
RKYMMKATKG DLENRPHSSL QTLCNGDLSS SGVAKGKVHC D
//
