ID F7EVU7_MONDO Unreviewed; 752 AA.
AC F7EVU7;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Lysyl oxidase like 4 {ECO:0000313|Ensembl:ENSMODP00000004562.4};
GN Name=LOXL4 {ECO:0000313|Ensembl:ENSMODP00000004562.4};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000004562.4, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000004562.4, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000004562.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Cu cation; Xref=ChEBI:CHEBI:23378;
CC Evidence={ECO:0000256|ARBA:ARBA00001935};
CC -!- SIMILARITY: Belongs to the lysyl oxidase family.
CC {ECO:0000256|ARBA:ARBA00007492}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00196}.
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DR AlphaFoldDB; F7EVU7; -.
DR Ensembl; ENSMODT00000004662.4; ENSMODP00000004562.4; ENSMODG00000003726.4.
DR eggNOG; ENOG502QSX8; Eukaryota.
DR GeneTree; ENSGT00940000157042; -.
DR HOGENOM; CLU_002555_3_0_1; -.
DR InParanoid; F7EVU7; -.
DR OMA; HMSEVRC; -.
DR TreeFam; TF326061; -.
DR Proteomes; UP000002280; Chromosome 1.
DR Bgee; ENSMODG00000003726; Expressed in skeleton of lower jaw and 16 other cell types or tissues.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR GO; GO:0004720; F:protein-lysine 6-oxidase activity; IBA:GO_Central.
DR GO; GO:0030199; P:collagen fibril organization; IBA:GO_Central.
DR Gene3D; 3.10.250.10; SRCR-like domain; 4.
DR InterPro; IPR001695; Lysyl_oxidase.
DR InterPro; IPR019828; Lysyl_oxidase_CS.
DR InterPro; IPR001190; SRCR.
DR InterPro; IPR017448; SRCR-like_dom.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR PANTHER; PTHR45817:SF5; LYSYL OXIDASE HOMOLOG 4; 1.
DR PANTHER; PTHR45817; LYSYL OXIDASE-LIKE-RELATED; 1.
DR Pfam; PF01186; Lysyl_oxidase; 1.
DR Pfam; PF00530; SRCR; 4.
DR PRINTS; PR00074; LYSYLOXIDASE.
DR PRINTS; PR00258; SPERACTRCPTR.
DR SMART; SM00202; SR; 4.
DR SUPFAM; SSF56487; SRCR-like; 4.
DR PROSITE; PS00926; LYSYL_OXIDASE; 1.
DR PROSITE; PS00420; SRCR_1; 2.
DR PROSITE; PS50287; SRCR_2; 4.
PE 3: Inferred from homology;
KW Copper {ECO:0000256|ARBA:ARBA00023008};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00196}; LTQ {ECO:0000256|ARBA:ARBA00022477};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW TPQ {ECO:0000256|ARBA:ARBA00022772}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..752
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023902995"
FT DOMAIN 32..133
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 161..287
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 307..407
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 417..525
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DISULFID 58..122
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 71..132
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 102..112
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 251..261
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 332..396
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 345..406
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 376..386
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 493..503
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
SQ SEQUENCE 752 AA; 83444 MW; 10112A1B9B5569BF CRC64;
PMWPPSLACS LILLWLCQAP LSSQQSLGSL KLRLVGAGSQ SEEGRLEVLH QGQWGTVCDD
DFSLQEAHVA CRQLGFEAAV TWAHSAKYGQ GEGHIWMDNV RCVGTESSLA GCRFNGWGVS
DCSHSEDVGV VCSPRRLPGH HAERLSQTLG PQGHRLEEVR IKPVLASAKR RNPTLEGAVE
VRLDGHWRQV CDQGWTMNNS RVVCGMLGFP SEVPVNTHFY RKLWNMKMKD PKSRLRSLTK
KNSFWIHRVS CLGTEAHLAQ CQLQVSPAKG KLRPACPTGI HAVVSCVAGP RFRHPKGKPR
RKEEPPVRLR AGAQVGEGRV EVLMHGQWGT VCDHGWNLIS ASVLCRQLGY GSAREALFGA
QLGQGLGLIH LSQVRCSGYE RALGDCPAHE GAQSGCQHNN DAAVRCHVPN MDLQKQIRLA
GGRSPEEGVV EVLVEVNGAP RWGAVCSDLW GLNEAMVACR QLGMGFASHA IQDTWYWQGT
PGAGKVVMSG VRCLGTELAL QQCQRHGPVH CSHGVGHFSA GVTCTDSAPD LVMNAQLVQE
TAYLEDRPLS LLYCAHEESC LSQSADHMNW PYGHRRLLRF SSQIHNLGRA DFRPKTGRHS
WTWHQCHRHY HSIEVFTHYD LLTVNGSKVA EGHKASFCLE DTNCPAGLQR RYACANFGEQ
GVTVGCWDTY RHDIDCQWVD ITDVPPGDYI FQVVVNPKFE VAESDFSNNM MRCRCKYDGH
RVWLHGCHTG DAYGAHTELS WEQQQRLMNN LI
//
