ID F7EYT9_ORNAN Unreviewed; 1217 AA.
AC F7EYT9;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=L1 cell adhesion molecule {ECO:0000313|Ensembl:ENSOANP00000014971.2};
GN Name=L1CAM {ECO:0000313|Ensembl:ENSOANP00000014971.2};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000014971.2, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000014971.2, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000014971.2,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000014971.2}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000014971.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily.
CC L1/neurofascin/NgCAM family. {ECO:0000256|ARBA:ARBA00008588}.
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DR AlphaFoldDB; F7EYT9; -.
DR STRING; 9258.ENSOANP00000014971; -.
DR Ensembl; ENSOANT00000014974.3; ENSOANP00000014971.2; ENSOANG00000009415.3.
DR eggNOG; KOG3513; Eukaryota.
DR GeneTree; ENSGT00940000157506; -.
DR HOGENOM; CLU_635453_0_0_1; -.
DR Proteomes; UP000002279; Chromosome 6.
DR Bgee; ENSOANG00000009415; Expressed in cerebellum and 6 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 4.
DR CDD; cd05845; IgI_2_L1-CAM_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 10.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR026966; Neurofascin/L1/NrCAM_C.
DR PANTHER; PTHR44170:SF44; L1 CELL ADHESION MOLECULE; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF13882; Bravo_FIGEY; 1.
DR Pfam; PF00041; fn3; 4.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 3.
DR SMART; SM00060; FN3; 5.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 5.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS50835; IG_LIKE; 6.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1086..1107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 14..109
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 117..204
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 218..306
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 311..394
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 399..481
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 492..581
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 588..683
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 685..781
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 786..886
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 890..982
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 665..698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1117..1217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 665..679
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1117..1146
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1217 AA; 136557 MW; 10C0234B49554E70 CRC64;
QFLGQYPAHR KCLPPVITNQ SQERIVVYPT DDVVLKCEAT GKPNVMFRWT RNHVLFRPEE
EQGVTTHNGS GSFTITGNNS NFAHRYTGVY RCYASNVLGT AMSHEIHVVA ESTPKWPKEK
VQPFEVEEGK SVILPCHPPS SVVPPRIYWM NSKLLHIMQD ERVTMGHNGN LYFANVLTSD
NHADYICHAH FLGARTIMQK RPIELRVKPT NSVKFRKPHL LLPSEPSTRL VALRGQKLAL
ECIAEGLPTP SITWSRPSAQ LQKGRVTFEN FNKTLWLEKV EEEDDGEYRC LAKNTQGSTQ
HTYYVSVEAA PYWSQKPESR CYGPGETVRL DCQVQGKPRP EVTWKINGVP LDDKNRKVQG
GALILSNVQP NDTMVTQCEA RNTHGLLLAN AFVYVIKLPT KILTKDGETY RTVEGSTVRL
ECKAFGAPVP SVQWLAESGV TVLQDDRFFP FTNGTLQIRD VRHNDTGSYF CLAANDQNNV
TIFANLEVKG ATRIERGPRN ETVKKLSNVT FQCHAWFDPT LNGTISWLMD GHKIQELPDN
DKFFLEYGRL TITNLDYSDQ GNYSCVAQTE VDSVEKTAEL LVVGSPGPVS QLKLSEQRNW
KVQLSWDPAE EHNSPIEKYI IEFEDETMEP GHWHFLSSVP GNQTSTKLQL SPYVHYNFRV
KATNKYGSSE PSQRSDTLLT PEAVPEKNPK DVKGEGNETN NMIISWKPLK WIDWNAPELS
YRVQWREKGK AERWQEQTVS GLALVVPHTP TFVPYEIKVQ AVNKVGKGPE PHIVIGYSGE
DFPQVAPQIE EINIVNRSTV KISWRPVNRT GLNGHLRGYN VRGKGASWRG GKRHIHRSHI
TVPGDKTEAI VGNLWPYSNY SFAVHVFNGR GLGPFSDQIA FQTPEGVPGP PESLSLEVLS
ESELKLTWQP PLRPNGILTG YVIEHEQGKP QLPKIELKDP EALQYNLSSL QARTHYRFSL
RATTSQGEGE AILKEGSTIL HLGECWGRAC TEVGKNFTVV SWVPQEGQHN VEFKILFESK
SVCESAVNSS QMFHTQGNLQ PSTHYYIKFL GHNFSEEMKQ FYQMEVDTNG MGLVPVKQGN
FATEGWFIGF ISAIVLLILI LLILCFIKRS KGGKYSVKDK EDTQVDSEAR PMKDETFGEY
SDNEEKPFES SQPSLNGDIK PLGSDDSLAD YGGSVDVQFN EDGSFIGQYS GKKEKEAAGG
NDSSGATSPT NPVVALE
//
