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Database: UniProt
Entry: F7F004_ORNAN
LinkDB: F7F004_ORNAN
Original site: F7F004_ORNAN 
ID   F7F004_ORNAN            Unreviewed;       363 AA.
AC   F7F004;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 2.
DT   24-JAN-2024, entry version 63.
DE   SubName: Full=Trans-2,3-enoyl-CoA reductase like {ECO:0000313|Ensembl:ENSOANP00000002757.2};
GN   Name=TECRL {ECO:0000313|Ensembl:ENSOANP00000002757.2};
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000002757.2, ECO:0000313|Proteomes:UP000002279};
RN   [1] {ECO:0000313|Ensembl:ENSOANP00000002757.2, ECO:0000313|Proteomes:UP000002279}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000002757.2,
RC   ECO:0000313|Proteomes:UP000002279};
RX   PubMed=18464734; DOI=10.1038/nature06936;
RA   Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA   Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA   Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA   Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA   Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA   Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA   Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA   Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA   Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA   Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA   Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA   Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA   Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA   Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA   Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA   Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA   Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA   Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA   de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT   "Genome analysis of the platypus reveals unique signatures of evolution.";
RL   Nature 453:175-183(2008).
RN   [2] {ECO:0000313|Ensembl:ENSOANP00000002757.2}
RP   IDENTIFICATION.
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000002757.2};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the steroid 5-alpha reductase family.
CC       {ECO:0000256|ARBA:ARBA00007742}.
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DR   RefSeq; XP_001511037.1; XM_001510987.2.
DR   AlphaFoldDB; F7F004; -.
DR   STRING; 9258.ENSOANP00000002757; -.
DR   Ensembl; ENSOANT00000002758.3; ENSOANP00000002757.2; ENSOANG00000001729.3.
DR   GeneID; 100077621; -.
DR   KEGG; oaa:100077621; -.
DR   CTD; 253017; -.
DR   eggNOG; KOG1639; Eukaryota.
DR   GeneTree; ENSGT00950000182886; -.
DR   HOGENOM; CLU_059260_1_0_1; -.
DR   InParanoid; F7F004; -.
DR   OMA; RQVSWTT; -.
DR   OrthoDB; 1202332at2759; -.
DR   TreeFam; TF300908; -.
DR   Proteomes; UP000002279; Chromosome 10.
DR   Bgee; ENSOANG00000001729; Expressed in heart and 2 other cell types or tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR   GO; GO:0016627; F:oxidoreductase activity, acting on the CH-CH group of donors; IEA:InterPro.
DR   GO; GO:0042761; P:very long-chain fatty acid biosynthetic process; IBA:GO_Central.
DR   CDD; cd17125; Ubl_TECRL; 1.
DR   InterPro; IPR001104; 3-oxo-5_a-steroid_4-DH_C.
DR   InterPro; IPR039357; SRD5A/TECR.
DR   InterPro; IPR049127; TECR-like_N.
DR   InterPro; IPR047822; TECRL_Ubl.
DR   PANTHER; PTHR10556; 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE; 1.
DR   PANTHER; PTHR10556:SF27; TRANS-2,3-ENOYL-COA REDUCTASE-LIKE; 1.
DR   Pfam; PF02544; Steroid_dh; 1.
DR   Pfam; PF21696; TECR_N; 1.
DR   PROSITE; PS50244; S5A_REDUCTASE; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        141..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        182..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        307..331
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          257..338
FT                   /note="Steroid 5-alpha reductase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50244"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   363 AA;  41659 MW;  D190DA54BD64550A CRC64;
     MFQRHKPLAS KYKRELSLQR GSQPPLQNDM KNFHSLSQLV LFAGPLKPSP AAKRSKTVHF
     EVEILDAQTR KQICIVDKIS PTSTLLDVKH KFHKTCPQWY PSRVGLQLER GGLFLKDSVS
     IQSLAASSIV TLYFTDLGQQ VGWTTVFLAE YTGPLLIYLL FYMRLTGIYD EKESFKKFRH
     PVVHLACFCH CLHYIRCLLE TLFVHKLSGG HTPLKNLIQG CAFYWGFTSW IAYYINHPRY
     TPPSFGNRQV TFSALSFLIC EAGNHFINVA LAHSNYTGNK SCFPGPTYNP FTWLYTLVSC
     PNYTYEIGSW ISFTIMTQTL PVGVFALLMT LQMSLWAQKK HKVYLKKFDS YVHRKSAMIP
     LIL
//
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