ID F7F0K9_ORNAN Unreviewed; 2444 AA.
AC F7F0K9;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Knl1 C-terminal RWD domain-containing protein {ECO:0000259|Pfam:PF18210};
GN Name=KNL1 {ECO:0000313|Ensembl:ENSOANP00000014709.3};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000014709.3, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000014709.3}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000014709.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 9258.ENSOANP00000014709; -.
DR Ensembl; ENSOANT00000014712.3; ENSOANP00000014709.3; ENSOANG00000009241.3.
DR eggNOG; ENOG502QW5H; Eukaryota.
DR GeneTree; ENSGT00410000025918; -.
DR HOGENOM; CLU_042928_0_0_1; -.
DR InParanoid; F7F0K9; -.
DR OMA; DINRNLW; -.
DR OrthoDB; 5354475at2759; -.
DR TreeFam; TF342884; -.
DR Proteomes; UP000002279; Unplaced.
DR Bgee; ENSOANG00000009241; Expressed in testis and 5 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0008608; P:attachment of spindle microtubules to kinetochore; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IEA:InterPro.
DR GO; GO:0034501; P:protein localization to kinetochore; IBA:GO_Central.
DR CDD; cd21853; KNL1_NTD; 1.
DR CDD; cd22892; Knl1_RWD_C; 1.
DR CDD; cd22817; Knl1_RWD_N; 1.
DR InterPro; IPR037388; Blinkin.
DR InterPro; IPR043651; KNL1_MELT_rep.
DR InterPro; IPR040850; Knl1_RWD_C.
DR PANTHER; PTHR16520; KINETOCHORE SCAFFOLD 1; 1.
DR PANTHER; PTHR16520:SF3; KINETOCHORE SCAFFOLD 1; 1.
DR Pfam; PF18210; Knl1_RWD_C; 1.
DR Pfam; PF19221; MELT; 17.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279}.
FT DOMAIN 2182..2334
FT /note="Knl1 C-terminal RWD"
FT /evidence="ECO:0000259|Pfam:PF18210"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 64..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 231..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 434..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 500..519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 525..587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 603..642
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 679..724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1196..1216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1233..1258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1293..1312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1490..1769
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1861..1968
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2172..2213
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..100
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..258
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 547..562
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 679..695
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1526..1540
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1643..1682
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1697..1717
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1727..1741
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1861..1901
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1923..1964
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2444 AA; 266627 MW; BDD6068DCB95B5FE CRC64;
MDTIYSEAME EKELTLPTQR RSSILKVPRS PLRDLRSGNE IIQDIGATKG RKSSRRVSFA
ETIKVFQRSP DSNSEEQPED LGKTAEEGEN IPLSQKERPE DMLCEISGMD TLLNAPIQAP
LQQTEGPTGG SAYGDRPADD RTVVFADENQ MDLTASHTVM ISQGLLERTE ESKKIDTKSF
LASLKDNTTG SERSESCGFS PNPNEAADEY VLQVEPNLPS DKKFNFSDLL SRLRPGQPTN
APGNGPDTEN TLTSLPSGDP GSDVCLLGQE DGSYRTRLFS EQDDGMDMTQ HHTAVIQTFG
PPGSEALLKP GECRGGTFGG PEDFMDLTVN QTGPIFSFGH EPSDRENWGS EVPVGLTSNP
GVCGILPQDP SPEDLTEMDI TRSHTVVIDN HTMPQATGGP APTWPSTAFP GAWAIFDASP
KEASENPVSF SAGAVSKNPL GSGQSYPKMP PKTEQAVPAS SGPIQKPLPL GGRLAVSSLD
AAEEMERTKS HTVAISLQDV EEATSQKAGS QTEAPLDARD LEKEEALEDP GAGIPSRRPP
SSDATGRDDV EVTTSQTLDI NSRVLKPALK GSSRGPEQLR KSLALSSSTS SSARGFAFLE
AQQNLGRPKS HPTVTDLGTG PALPKGDDTV PPSKICKPLS GLPNRALVTP DSLDKDFTQS
QAGPIKQDGF GLDFRQAQPT ANSEKTISTV PEHSSWPKKM PSKRASIAKP PATEKTQEFS
EGDMELTRCH TTSVEGKNVL GGQRAIRTNP PGLVDKTVVF ADDLDDLELT RSHTVNIDLN
RLEKTAIPDK STSEVGGKTG LAEPKAASTG SDKTIFFLED DQGDMEITKG LTVTLGGRSF
LLGEPQESGS LPLAAEKTVV FSDDLDDLEL TRSHTVNIDF KTLEKMTIPD KSMAEVFRRP
GLPEPVVLIP GSDKTIFFSE DDEDDMDITQ RHSDPVDGKN FVLSEWQETG MLPLPTEKTV
VFSDDLDDLE LTRSHTVNID FKILEKTVIP DKSASELVRR TGLAEPVVLS SGSDGTVFFS
EDDEGDMEIT KGHTIMGDGK IILTGEQQES GMLTVPAEKT VVFADHLDDL ELTRSHTVKI
DYQNLEKTVI PDKSMAEVVR GKGLAQPKAM STGSDQTIFF SGDGESDMEI TQRHTDPVSG
KSVLLGKQQE SGILTAPAEK TVVFADDLND LELTRSHTVN IDFKILERTT IPDKSTAEVD
RTGLTEPEMA STGSDKTIFF SGDGEGDMEI TQRHTDTVSD KSSLPGEQQG SGIPTAPAEK
TVVFADDPDD LELTRSHTVN IDFKIPERTT VPERSTAEVG RAGSAQPKMM SASSDKTIFF
SGDGESDMEI TQRHTDTVGG KSVLLGKQQE SGKLTVPAEK TVVFSDNLDD LELTRSHTVN
IDFKIPERSM IPDKSTAEVD RRAGLAEPRV ASALSDKTVF LSGVGSDAVG ITRRHSVLPG
ERRVSGVVPA PAEEAVVFSA NLDGLEPTSS HPADPGYETL EKMRIQDKCS SEGNWRKSLT
GPKTEPPPDD SPRKCHTLAL GQDLEKVVKP KSKRVSFKLP EGRSENLPAK AGESQGKETP
EDDVFFTSPP PPGLEEKRHD VSGPKASKPP GPENGNPKGP VGERPVAACE NESQMFRAAQ
EPDSLGERKG KENVPAHGGD SAGGDSQTKS DPPTQMDPIP SSASQLPEPA VPSETSGITN
IKVQLRKMKR KSEVISPPQT DPKSNVPEQS STAAQQADDY VPAAKSRDHP STSSKTSPGD
RPPSKGKTDP RDADPPGAGS ASAQPVLKEK SKVGRHSLWV FLPKLPNRRN CSVTGVEGPE
ERPEVLYDQQ FLDSQPSTSQ AGNFAFFDAQ TKLSPTGYIS EEFLPGAPEE TDSLEAWEEM
GLRESPSRHD AVQEASSSHK RSRPLEDADK HLDKKVRKTR SSSVGAAEQS HQAEDQKGKS
SPGHLAKSLS RTPASCSSSL DSTKAEGSSM DFSMQRSSHM ESQFSRDSMC EESLKEKLKD
GRITVGEFFT LLQVHILIQK PRQSKLPGNY ALNAPSSPED LFMSQYVYRP KIQVYEEDCQ
ALRQTIEELK LCTKSQDKLL VDVNRSLWEV MRGCSDEELK TFGEDLNKMK SRFTKKSKLL
AHQRKVALYS KLVQSSQLQW EKLQSGMERT DSMLEEADSC LAVLQIETEI LEQCEEDASP
DSDSDMEWKC GMRAVKQELE SLQSQEEELL RTVADLKREK QQALSTMSLW QEETKRAEKW
ISKLTFSEWE IKEWNNQQAS FTFLYDSLDL TFTFGEPVGN SLFNDKPCRT VIDVNFESQL
DVDRVPPSTL LVHRLIFQFI EEQGSWKEAY PTQLQIPKML HDFSLVVSRC RLLGDEIEFL
SRWGPKYSLI KIAVNGNEVK LLFSSTASFA KFELTMSLSA SYPMVPLPFT FQNRIGKISQ
DDVAAVLSRV PLGSNYLKTA VQLIHRDLLQ GPPKGPLSPG EAPQ
//
