ID F7F494_CALJA Unreviewed; 316 AA.
AC F7F494;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Ectodysplasin A2 receptor {ECO:0000313|Ensembl:ENSCJAP00000006527.4};
GN Name=EDA2R {ECO:0000313|Ensembl:ENSCJAP00000006527.4};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000006527.4, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000006527.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000006527.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; F7F494; -.
DR STRING; 9483.ENSCJAP00000006527; -.
DR Ensembl; ENSCJAT00000006891.5; ENSCJAP00000006527.4; ENSCJAG00000003590.5.
DR GeneTree; ENSGT00940000153259; -.
DR InParanoid; F7F494; -.
DR Proteomes; UP000008225; Chromosome X.
DR Bgee; ENSCJAG00000003590; Expressed in ovary.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005031; F:tumor necrosis factor receptor activity; IEA:InterPro.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:InterPro.
DR GO; GO:0046330; P:positive regulation of JNK cascade; IEA:InterPro.
DR CDD; cd15838; TNFRSF27; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 1.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR022319; TNFR_27.
DR InterPro; IPR034060; TNFRSF27_N.
DR InterPro; IPR047526; TNR19/27/EDAR.
DR PANTHER; PTHR12120; TNFR-CYS DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12120:SF8; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 27; 1.
DR Pfam; PF00020; TNFR_c6; 2.
DR PRINTS; PR01973; TNFACTORR27.
DR SMART; SM00208; TNFR; 2.
DR SUPFAM; SSF57586; TNF receptor-like; 1.
DR PROSITE; PS00652; TNFR_NGFR_1; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00206}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 139..162
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2..41
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 2..41
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 43..83
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 43..83
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT REGION 204..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 286..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 286..303
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 18..31
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 316 AA; 34735 MW; 99D0439F4934B87A CRC64;
MDCQENEYLD QWGRCVTCQQ CGPGQELSKD CGYGEGGDAY CTACPPHRYK SSWGHHRCQT
CITCAVINRV QKFNCTATSN AVCGDCLPRF YRKTRIGGLQ DQECIPCTKQ TPTSEVQCAF
QLSLVEADEP TVPPQEATLV ALVSSLLVVF TLAFLGLFFL YCKQFFNRHC QREKLIIFPD
PVPGNNLIPK FAGGSLQFEA DKAAEEESLF PMPPSKETSP ESQVSESIFQ TQPLNPILED
DCSSTGGFPT QESFTMASCA SESHSHWVHN PIECTELDLQ KFSSSASYTG AETGGNTAES
TGDRLELNVP FEVPSP
//
