ID F7FAH1_ORNAN Unreviewed; 920 AA.
AC F7FAH1;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN Name=ANO2 {ECO:0000313|Ensembl:ENSOANP00000021293.3};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000021293.3, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000021293.3}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000021293.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU280814}.
CC -!- SIMILARITY: Belongs to the anoctamin family.
CC {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU280814}.
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DR AlphaFoldDB; F7FAH1; -.
DR STRING; 9258.ENSOANP00000021293; -.
DR Ensembl; ENSOANT00000021296.3; ENSOANP00000021293.3; ENSOANG00000036505.1.
DR eggNOG; KOG2514; Eukaryota.
DR GeneTree; ENSGT00940000155840; -.
DR HOGENOM; CLU_832967_0_0_1; -.
DR TreeFam; TF314265; -.
DR Proteomes; UP000002279; Unplaced.
DR Bgee; ENSOANG00000036505; Expressed in endometrium and 5 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR InterPro; IPR032394; Anoct_dimer.
DR InterPro; IPR007632; Anoctamin.
DR InterPro; IPR049452; Anoctamin_TM.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF20; ANOCTAMIN-2; 1.
DR Pfam; PF16178; Anoct_dimer; 1.
DR Pfam; PF04547; Anoctamin; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU280814};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU280814}.
FT TRANSMEM 288..312
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 364..381
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 456..482
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 502..524
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 544..565
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 672..695
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 723..747
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT DOMAIN 40..214
FT /note="Anoctamin dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16178"
FT DOMAIN 277..865
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
FT REGION 1..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 223..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 887..920
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..52
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 223..238
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 888..920
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 920 AA; 104927 MW; 98A7E6A591099741 CRC64;
PPHPGVEPRP PPPIPPRSSR SRCKSHSAPS PEPRQSGMRF VDDERKVDYV LAYHSRRPSP
ATVPNGETGK EPTGAGPLGA LEEQREEQRE EFERNLMDAG LELEKDAEKK SHGGICFVRI
HAPWLVLARE AEFLKIKVPT KKTYEIKEEG AIMKTMNKAL RAILAPLQPT VSEHSPSKMK
NLSYPFSREK MYLYNIQDKD SFFDNATRSR IVSNGGMRGY WGRGRRRART HSQRLPRASP
RRYPRLPSND IGQPGGLHPR EWAQYGAFYK YQPIDLIRKY FGEKIGLYFA WLGLYTEFLI
PSSVIGVVVF LYGCATLEED VPSQELCDER SGFTMCPLCD QACDYWNLSS ACGTARASHL
FDNPATVVFS IFMALWATMF LEHWKRLQMR LGYFWDLTGI EEEEEHSRPE YETKVREKVL
RERGDAGLQD VQVITVEPEE ENDEDKLAWK DRFPGYLMNC ASILFMIALT FSIVFGVIVY
RITTAAALYL SKASPSSVRM TVKATAVIIN LVVILILDEL YGAVAKWLTK IEIPKTEQAF
EERLILKAFL LKFVNAFSPI FYVAFFKGRF VGRPGHYVYV FHGYRMEECA PGGCLMELCI
QLSIIMLGKQ LIQNNIFEIG VPKLKKLFRS LKSEVDLPAA DTDSVQSRHP MQWERDYGLE
PYTGLTPEYM EMVIQFGFVT LFVASFPLAP VFALLNNVIE VRLDAKKFVT ELRRPDAVRT
KDIGIWFDIL TGIGKFSVII NAFVIAITSD FIPRLVYQYG YSPDGSLHGF VNHTLSYFNV
SQLKEGTQPA DSQFHQDGLL CRFKDYREPP WAAHQYEFSK QYWAVLSARL AFVIVFQNLV
MFLSALVDWL IPDIPQDISD QIKKEKSLLV DFFLKEEHEK LKVVDQLAQR SRASSFRASS
PRASSFRASS PRASRGINGS
//
