ID F7FCW8_MONDO Unreviewed; 1965 AA.
AC F7FCW8;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Dedicator of cytokinesis 4 {ECO:0000313|Ensembl:ENSMODP00000019937.4};
GN Name=DOCK4 {ECO:0000313|Ensembl:ENSMODP00000019937.4};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000019937.4, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000019937.4, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000019937.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR STRING; 13616.ENSMODP00000019937; -.
DR Ensembl; ENSMODT00000020293.4; ENSMODP00000019937.4; ENSMODG00000015971.4.
DR eggNOG; KOG1998; Eukaryota.
DR eggNOG; KOG3166; Eukaryota.
DR GeneTree; ENSGT00940000155659; -.
DR HOGENOM; CLU_000595_2_0_1; -.
DR InParanoid; F7FCW8; -.
DR OMA; MRDFGHS; -.
DR TreeFam; TF300423; -.
DR Proteomes; UP000002280; Chromosome 8.
DR Bgee; ENSMODG00000015971; Expressed in liver and 17 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0032420; C:stereocilium; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0030165; F:PDZ domain binding; IEA:Ensembl.
DR GO; GO:0030971; F:receptor tyrosine kinase binding; IEA:Ensembl.
DR GO; GO:0031267; F:small GTPase binding; IBA:GO_Central.
DR GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR GO; GO:1904694; P:negative regulation of vascular associated smooth muscle contraction; IEA:Ensembl.
DR GO; GO:1904754; P:positive regulation of vascular associated smooth muscle cell migration; IEA:Ensembl.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08695; C2_Dock-B; 1.
DR CDD; cd11705; DHR2_DOCK4; 1.
DR CDD; cd12049; SH3_DOCK4_B; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.1270.350; Dedicator of cytokinesis N-terminal subdomain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037811; C2_Dock-B.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037014; DHR2_DOCK4.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR035769; DOCK4_SH3.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR032376; DOCK_N.
DR InterPro; IPR042455; DOCK_N_sub1.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR PANTHER; PTHR45653:SF7; DEDICATOR OF CYTOKINESIS PROTEIN 4; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF16172; DOCK_N; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 3..64
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 398..571
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1196..1602
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 1654..1965
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1472..1499
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1654..1705
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1708..1722
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1763..1779
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1804..1886
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1965 AA; 225456 MW; 462DC97F175FA5C0 CRC64;
MICSKLSFAV IASFRATVPY GLSLEIGDTV QILEKCDGWY RGFALKNPNI KGIFPSSYIH
LKNACVKNKG QFEMVIPTED SVITEMTSTL RDWGTMWKQL YVRNEGDLFH RLWHIMNEIL
DLRRQVLVGH LTHDRMKDVK RHITARLDWG NEQLGLDLVP RKEYAMVDPE DISITELYRL
MEHRHRKKDT PVQASSHHLF VQMKSLMCSN LGEELEVIFS LFDSKENRPI SERFFLRLNR
NGLPKSPEKP ERHCSLFVDL GSSELRKDIY ITVHIIRIGR MGAGEKKNAC SVQYRRPFGC
AVLSIADLLT GETKDDLILK VYMCNTESEW YQIHENIIKK LNARYNLTGS NAGLAVSLQL
LHGDIEQIRR EYSSVFTHGV SITRKLGFSN IIMPGEMRND LYITIERGEF EKGGKSVARN
VEVTMYIIDS NGQNLKDFIS FGSGEPPANE FHSFVLYHNN SPRWSELLKL PIPVDKFRGS
HIRFEFRHCS TKEKGEKKLF GFSFVPLMQE DGRTLPDGTH ELIVHKCEEN TNLQDSSRYL
RLPFSKVSLL GTNNQAIKAT KESFWITSFL CSTKLTQNGD MLDLLKWRTH PDKITGCLSK
IKEIDGSEIV KFLQDTLDTL FGILDENSQK YGSKVFDSLV HIINLLQDSK FHHFKPVMDT
YIESHFAGAL AYRDLIKVLK WYVDRITEAE RQEHIQEVLK AQEYIFKYIV QSRRLFSLAT
GGQNEEEFRC CIQELLMSVR FFLSQESKGS GALSQSQAVF LSSFPAVYSE LLKLFDVREV
ANLVHDTLGS LPTIMHVDDS LQAVKLQCIG KTVESQLYTN PDSRYILLPV VLHHLHMHLQ
EQKDLIMCAR ILSNIFCLIK KNSSEKSVLE EIDVIVTSLL DILLRTILEI TSRPQPSGSA
MRLQFQDVTG EFVACLLSLL RQMTDRHYQQ LLDGFSTKEE LRDFLLQIFT VFRILIRPEM
FPKDWTVMRL VANNVIITTV LYLSDALRKN FLNENFDYKI WDSYFYLAVI FINQLCLQLE
MFTPSKKKKV LEKYGDMRVT MGCEIFSMWQ NLGEHKLHFI PALIGPFLEV TLIPQPDLRN
VMIPIFHDMM DWEQRRSGNF KQVEAKLIDK LDSLMSEGKG DETYRELFNS IIPLFGPYPS
LLKKIERETW RESGVSLIAT VTRLMERLLD YRDCMKMGEV DGKKIGCTVS LLNFYKTELN
KEEMYIRYIH KLYDLHLKAQ NFTEAAYTLL LYDELLEWSD RPLREFLTYP MQTEWQRKEY
LHLTIIQNFD RGKCWENGII LCRKIAEQYE SYYDYRNLSK MRMMEASLYD KIMDQQRLEP
EFFRVGFYGK KFPFFLRNKE FVCRGHDYER LEAFQQRMLN EFPHAIAMQH ANQPDETIFQ
AEAQYLQIYA VTPIPESQEV LQREGIPDNI KSFYKVNHIW RFRYDRPFHK GTKDKENEFK
SLWVERTSLI LVQSLPGISR WFEVEKREVV EMSPLENAIE VLENKNQQLK TLISQCQTRQ
MQNINPLTMC LNGVIDAAVN GGVSRYQEAF FVKEYILNHP EDGEKITRLR ELMLEQAQIL
EFGLAVHEKF VPQDMRPLHK KLVDQFFVMK SSLGIQEFSA CIQASPVHFP NGSPRVCRNS
APASMSPDGA RVIPRRSPLS YPAVNRYSSS SLSSQASAEV SNITGQSESS DEVFNMQPSP
STSSLSSTHS ASPNVTSSAP SSARASPLLS DKHKHSRENS CLSPRERPCS AIYPTPTEPS
QRMLFNHIGD GPLPRSDPNL SAPDKAVNPT PSSWSLDSGK EAKNMLDSGK LISPPVPPRP
TQTASPARHG TSVSPSPAGR SPMKGSMQSF TPSPVEYHSS GLISNSPVLS GSYSSGISSL
SRCSTSETSG FENPVNEQTV SMSTYSVPEE PVRKESKTPP PYSVYERTLR RPAPLPHSLS
IPVTSEPPAL PPKPLLARST NLENGSRRTE QVPRPRPLPR KVSQL
//
