ID F7FDG5_MACMU Unreviewed; 568 AA.
AC F7FDG5;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Bridging integrator 2 {ECO:0000313|Ensembl:ENSMMUP00000030490.4};
GN Name=BIN2 {ECO:0000313|Ensembl:ENSMMUP00000030490.4,
GN ECO:0000313|VGNC:VGNC:99898};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000030490.4, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000030490.4}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000030490.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F7FDG5; -.
DR SMR; F7FDG5; -.
DR Ensembl; ENSMMUT00000032583.4; ENSMMUP00000030490.4; ENSMMUG00000023163.4.
DR VEuPathDB; HostDB:ENSMMUG00000023163; -.
DR VGNC; VGNC:99898; BIN2.
DR GeneTree; ENSGT00950000182882; -.
DR HOGENOM; CLU_816272_0_0_1; -.
DR Proteomes; UP000006718; Chromosome 11.
DR Bgee; ENSMMUG00000023163; Expressed in spleen and 22 other cell types or tissues.
DR ExpressionAtlas; F7FDG5; baseline.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0043226; C:organelle; IEA:UniProt.
DR CDD; cd07612; BAR_Bin2; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR003005; Amphiphysin.
DR InterPro; IPR046984; BAR_Bin2.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR048886; Bin2_C.
DR PANTHER; PTHR46514; AMPHIPHYSIN; 1.
DR PANTHER; PTHR46514:SF1; BRIDGING INTEGRATOR 2; 1.
DR Pfam; PF03114; BAR; 1.
DR Pfam; PF21532; Bin2_C; 1.
DR PRINTS; PR01251; AMPHIPHYSIN.
DR SMART; SM00721; BAR; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR PROSITE; PS51021; BAR; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718}.
FT DOMAIN 60..276
FT /note="BAR"
FT /evidence="ECO:0000259|PROSITE:PS51021"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 298..568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 188..222
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 298..325
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 342..361
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..394
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 406..425
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 456..498
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 512..568
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 568 AA; 61836 MW; C76BD5C3F149D85B CRC64;
MRGMLGARTS SSGASENHRA LGQGGGPRGA GTMAEGKAGG AAGLFAKQVQ KKFSRAQEKV
LQKLGKAVET KDERFEQSAN NFYQQQAEGY KLYKDLKNFL SAVKVMHESS KRVSETLQEI
YNSEWDGHEE LKTIVGNNDL LWEDYEEKLA DQAVRTMENY VAQFSEIKER IAKRGRKLVD
YDSTRHHLEA VQNAKKKDEA KTAKAEEEFN KAQTVFEDLN QELLEELPIL YNSRIGCYVT
IFQNISNLRD VFYREMSKLN HNLYEVMSKL EKQHSNKVFV VKGLSSRRSL VISPPVQTTM
VSSPLTSPTS PSTLSLKSES ESVSATEDLA PDAAQGDDNS EIKELLEDEE IEKEGSEASS
SEEEEPLPAC NGPSQAQPSL TIESVKSQEE VLPSSPAPSP GEAPSPSGQP SSSAAEVVLR
TRTASEGSEQ PKKRASLQRT SAPPSRPPPP RATASPRPSS GNIPSSPPAS GGGSPTSPRA
SLGTGTPSPR TSLEVSPNPE TPEKPVRTPE AKENENMNNQ NPEELCTSPT LMTSQGQDQL
QVSAVPENNN LTAPEPQEEV STSENPQL
//
