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Database: UniProt
Entry: F7FEF9_MACMU
LinkDB: F7FEF9_MACMU
Original site: F7FEF9_MACMU 
ID   F7FEF9_MACMU            Unreviewed;      2734 AA.
AC   F7FEF9;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 2.
DT   05-DEC-2018, entry version 43.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor type 1 {ECO:0000313|Ensembl:ENSMMUP00000016510};
GN   Name=ITPR1 {ECO:0000313|Ensembl:ENSMMUP00000016510};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000016510, ECO:0000313|Proteomes:UP000006718};
RN   [1] {ECO:0000313|Ensembl:ENSMMUP00000016510, ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000016510,
RC   ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
RA   Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
RA   Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
RA   Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
RA   Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
RA   Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
RA   Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
RA   Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
RA   Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
RA   Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
RA   Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
RA   Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
RA   Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
RA   Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
RA   Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
RA   Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
RA   Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
RA   Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
RA   Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
RA   Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
RA   Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
RA   Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
RA   Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
RA   Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
RA   Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
RA   Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
RA   Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque
RT   genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMMUP00000016510}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000016510};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; JSUE03023307; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03023308; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03023309; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSMMUT00000017630; ENSMMUP00000016510; ENSMMUG00000012574.
DR   eggNOG; KOG3533; Eukaryota.
DR   eggNOG; ENOG410XR97; LUCA.
DR   GeneTree; ENSGT00940000155071; -.
DR   Proteomes; UP000006718; Chromosome 2.
DR   Bgee; ENSMMUG00000012574; Expressed in 14 organ(s), highest expression level in cerebellum.
DR   ExpressionAtlas; F7FEF9; baseline.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006718};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2259   2281       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2293   2311       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2380   2405       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2425   2447       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2555   2578       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       88    142       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      149    199       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      207    263       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      270    349       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      355    411       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED     1579   1599       {ECO:0000256|SAM:Coils}.
FT   COILED     2672   2713       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2734 AA;  311858 MW;  8A0271D5C48C081B CRC64;
     RRGFTMLTRL VLNSCPQVIH LNFCLFALLL DCLFKLCPMN RYSAQKQFWK AAKPGANSTT
     DAVLLNKLHH AADLEKKQNE TENRKLLGTV IQYGNVIQLL HLKSNKYLTV NKRLPALLEK
     NAMRVTLDEA GNEGSWFYIQ PFYKLRSIGD SVVIGDKVVL NPVNAGQPLH ASSHQLVDNP
     GCNEVNSVNC NTSWKIVLFM KWSDNKDDIL KGGDVVRLFH AEQEKFLTCD EHRKKQHVFL
     RTTGRQSATS ATSSKALWEV EVVQHDPCRG GAGYWNSLFR FKHLATGHYL AAEVDPDFEE
     ECLEFQPSVD PDQDASRSRL RNAQEKMVYS LVSVPEGNDI SSIFELDPTT LRGGDSLVPR
     NSYVRLRHLC TNTWVHSTNI PIDKEEEKPV MLKIGTSPVK EDKEAFAIVP VSPAEVRDLD
     FANDASKVLG SIAGKLEKGT ITQNERRSVT KLLEDLVYFV TGGTNSGQDV LEVVFSKPNR
     ERQKLMREQN ILKQIFKLLQ APFTDCGDGP MLRLEELGDQ RHAPFRHICR LCYRVLRHSQ
     QDYRKNQEYI AKQFGFMQKQ IGYDVLAEDT ITALLHNNRK LLEKHITAAE IDTFVSLVRK
     NREPRFLDYL SDLCVSMNKS IPVTQELICK AVLNPTNADI LIETKLVLSR FEFEGVSSTG
     ENALEAGEDE EEVWLFWRDS NKEIRSKSVR ELAQDAKEGQ KEDRDVLSYY RYQLNLFARM
     CLDRQYLAIN EISGQLDVDL ILRCMSDENL PYDLRASFCR LMLHMHVDRD PQEQVTPVKY
     ARLWSEIPSE IAIDDYDSSG ASKDEIKERF AQTMEFVEEY LRDVVCQRFP FSDKEKNKLT
     FEVVNLARNL IYFGFYNFSD LLRLTKILLA ILDCVHVTTI FPISKMAKGE ENKGNNDVEK
     LKSSNVMRSI HGVGELMTQV VLRGGGFLPM TPMAAAPEGN VKQAEPEKED IMVMDTKLKI
     IEILQFILNV RLDYRISCLL CIFKREFDES NSQTSETSSG NISQEGPSNV PGALDFEHIE
     EQAEGIFGGR KENTPLDLDD HGGRTFLRVL LHLTMHDYPP LVSGALQLLF RHFSQRQEVL
     QAFKQVQLLV TSQDVDNYKQ IKQDLDQLRS IVEKSELWVY KGQGPDETMD GASGENGHKK
     TEEGNNKSQK HESTSSYNYR VVKEILIRLS KLCVQESASV RKSRKQQQRL LRNMGAHAVV
     LELLQIPYEK AEDTKMQEIM RLAHEFLQNF CAGNQQNQAL LHKHINLFLN PGILEAVTMQ
     HIFMNNFQLC SEINERVVQH FVHCIETHGR NVQYIKFLQT IVKAEGKFIK KCQDMVMAEL
     VNSGEDVLVF YNDRASFQTL IQMMRSERDR MDENSPLMYH IHLVELLAVC TEGKNVYTEI
     KCNSLLPLDD IVRVVTHEDC IPEVKIAYIN FLNHCYVDTE VEMKEIYTSN HMWKLFENFL
     VDICRACNNT SDRKHADSIL EKYVTEIVMS IVTTFFSSPF SDQSTTLQTR QPVFVQLLQG
     VFRVYHCNWL MPSQKASVES CIRVLSDVAK SRAIAIPVDL DSQVNNLFLK SHNIVQKTAM
     NWRLSARNAA RRDSVLAASR DYRNIIERLQ DIVSALEDRL RPLVQAELSV LVDVLHRPEL
     LFPENTDARR KCESGGFICK LIKHTKQLLE ENEEKLCIKV LQTLREMMTK DRGYGEKLIS
     IDELDNAEVL IFVVLKMEFL HLEPSPPLRQ LEDHKRGEAL RQILVNRYYG NIRPSGRRES
     LTSFGNGPLS PGGPSKPGGG GGGSGSSSMS RGEMSLAEVQ CHLDKEGASN LVIDLIMNAS
     SDRVFHESIL LAIALLEGGN TTIQHSFFCR LTEDKKSEKF FKVFYDRMKV AQQEIKATVT
     VNTSDLGNKK KDDEVDRDAP SRKKAKEPTT QITEEVRDQL LEASAATRKA FTTFRREADP
     DDHYQPGEGT QATADKTKDD LEMSAVITIM QPILRFLQLL CENHNRDLQN FLRCQNNKTN
     YNLVCETLQF LDCICGSTTG GLGLLGLYIN EKNVALINQT LESLTEYCQG PCHENQNCIA
     THESNGIDII TALILNDINP LGKKRMDLVL ELKNNASKLL LAIMESRHDS ENAERILYNM
     RPKELVEVIK KAYMQGEVEF EDGENGEDGA ASPRNVGHNI YILAHQLARH NKELQSMLKP
     GGQVDGDEAL EFYAKHTAQI EIVRLDRTME QIVFPVPSIC EFLTKESKLR IYYTTERDEQ
     GSKINDFFLR SEDLFNEMNW QKKLRAQPVL YWCARNMSFW SSISFNLAVL MNLLVAFFYP
     FKGVRGGTLE PHWSGLLWTA MLISLAIVIA LPKPHGIRAL IASTILRLIF SVGLQPTLFL
     LGAFNVCNKI IFLMSFVGNC GTFTRGYRAM VLDVEFLYHL LYLVICAMGL FVHEFFYSLL
     LFDLVYREET LLNVIKSVTR NGRSIILTAV LALILVYLFS IVGYLFFKDD FILEVDRLPN
     ETAVPETGES LASEFLFSDV CRVESGENCS SPAPKEELVP AEETEQDKEH TCETLLMCIV
     TVLSHGLRSG GGVGDVLRKP SKEEPLFAAR VIYDLLFFFM VIIIVLNLIF GVIIDTFADL
     RSEKQKKEEI LKTTCFICGL ERDKFDNKTV TFEEHIKEEH NMWHYLCFIV LVKVKDSTEY
     TGPESYVAEM IKERNLDWFP RMRAMSLVSS DSEGEQNELR NLQEKLESTM KLVTNLSGQL
     SELKDQMTEQ RKQKQRIGLL GHPPHMNVNP QQPA
//
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