ID F7FEL8_ORNAN Unreviewed; 723 AA.
AC F7FEL8;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=NCK interacting protein with SH3 domain {ECO:0000313|Ensembl:ENSOANP00000002932.2};
GN Name=NCKIPSD {ECO:0000313|Ensembl:ENSOANP00000002932.2};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000002932.2, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000002932.2, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000002932.2,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000002932.2}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000002932.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F7FEL8; -.
DR STRING; 9258.ENSOANP00000002932; -.
DR Ensembl; ENSOANT00000002933.3; ENSOANP00000002932.2; ENSOANG00000001846.3.
DR eggNOG; KOG4035; Eukaryota.
DR GeneTree; ENSGT00390000015725; -.
DR HOGENOM; CLU_012978_1_0_1; -.
DR TreeFam; TF324522; -.
DR Proteomes; UP000002279; Chromosome X1.
DR Bgee; ENSOANG00000001846; Expressed in brain and 8 other cell types or tissues.
DR CDD; cd11849; SH3_SPIN90; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR030125; SPIN90/Ldb17.
DR InterPro; IPR018556; SPIN90/Ldb17_LRD.
DR InterPro; IPR035514; SPIN90_SH3.
DR PANTHER; PTHR13357:SF1; NCK-INTERACTING PROTEIN WITH SH3 DOMAIN; 1.
DR PANTHER; PTHR13357; SH3 ADAPTER PROTEIN SPIN90 NCK INTERACTING PROTEIN WITH SH3 DOMAIN; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF09431; SPIN90_LRD; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..58
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 103..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 213..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..129
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..229
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 240..269
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 723 AA; 79933 MW; ACDE1A31212C7166 CRC64;
MYRSLYAFSS AEPNSLRFGA GETFLILERS NEHWWLASRA RSGETGYIPP AYLHRIQVLE
QDVVLQSIDR AIEAIHNAAM KNGGKYNLEQ RDVLQKLIHH RKETLSRKGH AATSQVTMTP
SSSDHHLDAT RQPNGVCRTG YERHHSLPTS EFLGEDDGLY QIPPQPRRAA PITPPPPEKR
RNAQMVASGK NAVEIPSGSV SSASSVSTTS LDTLYTGSSM SEPGPTTARS SPANTPPPVP
SRSAHTSISR SLDLGPPTQG ASSSGEAANP LQAKRAAPEI PPGEEPQSPA ISEEEQPKRT
ASASHAGLEA FDSLCLDDEK KAGAEVPEPE SPGPSVSVPK TIGAELMELV RRNTNLSYDL
SRVAIGVVVG HIQSSIPATN GIMEQILISL VESKDLSSGL PSGQICHDEQ RLEVIFADLA
RHKDDAQQRS WALYEDENVI CCYLEELLHI LEHRVSLRLL LLKCFGAMCN LDAAIISTLV
NSVLPMELAR DMQTHTQDHQ KLCYSALVLA MIFSMGEPLP YHHYEHLNSQ FVQFLLDVIE
DGLPSDTTDQ LPDLFINVLL AFNLHIPVPE HNVIMTTVSK HPNVKIFTEK VLLLLNRGDD
PVCIFKHQPQ PPHSVLKFLQ DIFASKDTAG IFYHTDMMVM IDIMVRQIAD LSPGDKLRME
YLSLMHAVIR STAYLKHRHR LADLQGTLQR ILGEQEEGPP CQMDKMIIRE IYKEFPEIAQ
AAS
//
