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Database: UniProt
Entry: F7FEW8_CALJA
LinkDB: F7FEW8_CALJA
Original site: F7FEW8_CALJA 
ID   F7FEW8_CALJA            Unreviewed;       358 AA.
AC   F7FEW8;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   24-JAN-2024, entry version 73.
DE   RecName: Full=Na(+)/H(+) exchange regulatory cofactor NHE-RF {ECO:0000256|PIRNR:PIRNR037866};
GN   Name=SLC9A3R1 {ECO:0000313|Ensembl:ENSCJAP00000027272.1};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000027272.1, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000027272.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000027272.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- FUNCTION: Scaffold protein that connects plasma membrane proteins with
CC       members of the ezrin/moesin/radixin family and thereby helps to link
CC       them to the actin cytoskeleton and to regulate their surface
CC       expression. {ECO:0000256|PIRNR:PIRNR037866}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC       Cell projection, filopodium {ECO:0000256|ARBA:ARBA00004486}. Cell
CC       projection, microvillus {ECO:0000256|ARBA:ARBA00004105}. Cell
CC       projection, ruffle {ECO:0000256|ARBA:ARBA00004466}. Endomembrane system
CC       {ECO:0000256|ARBA:ARBA00004184, ECO:0000256|PIRNR:PIRNR037866};
CC       Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004184,
CC       ECO:0000256|PIRNR:PIRNR037866}.
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DR   RefSeq; XP_003733107.2; XM_003733059.3.
DR   AlphaFoldDB; F7FEW8; -.
DR   STRING; 9483.ENSCJAP00000027272; -.
DR   Ensembl; ENSCJAT00000028827.4; ENSCJAP00000027272.1; ENSCJAG00000014794.5.
DR   GeneID; 100415587; -.
DR   KEGG; cjc:100415587; -.
DR   CTD; 9368; -.
DR   eggNOG; KOG3528; Eukaryota.
DR   GeneTree; ENSGT00950000182849; -.
DR   HOGENOM; CLU_038627_1_0_1; -.
DR   InParanoid; F7FEW8; -.
DR   OMA; NGQIHGH; -.
DR   OrthoDB; 2914289at2759; -.
DR   Proteomes; UP000008225; Chromosome 5.
DR   Bgee; ENSCJAG00000014794; Expressed in kidney and 6 other cell types or tissues.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0031526; C:brush border membrane; IEA:Ensembl.
DR   GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:GOC.
DR   GO; GO:0005902; C:microvillus; IEA:Ensembl.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR   GO; GO:0097225; C:sperm midpiece; IEA:Ensembl.
DR   GO; GO:0032426; C:stereocilium tip; IEA:Ensembl.
DR   GO; GO:0031698; F:beta-2 adrenergic receptor binding; IEA:Ensembl.
DR   GO; GO:0008013; F:beta-catenin binding; IEA:Ensembl.
DR   GO; GO:0099103; F:channel activator activity; IEA:Ensembl.
DR   GO; GO:0017081; F:chloride channel regulator activity; IEA:Ensembl.
DR   GO; GO:0050780; F:dopamine receptor binding; IEA:Ensembl.
DR   GO; GO:0070851; F:growth factor receptor binding; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0060090; F:molecular adaptor activity; IEA:InterPro.
DR   GO; GO:0030165; F:PDZ domain binding; IEA:Ensembl.
DR   GO; GO:0019902; F:phosphatase binding; IEA:Ensembl.
DR   GO; GO:0043621; F:protein self-association; IEA:Ensembl.
DR   GO; GO:0031799; F:type 2 metabotropic glutamate receptor binding; IEA:Ensembl.
DR   GO; GO:0031800; F:type 3 metabotropic glutamate receptor binding; IEA:Ensembl.
DR   GO; GO:0030036; P:actin cytoskeleton organization; IEA:Ensembl.
DR   GO; GO:0007191; P:adenylate cyclase-activating dopamine receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0060088; P:auditory receptor cell stereocilium organization; IEA:Ensembl.
DR   GO; GO:0032782; P:bile acid secretion; IEA:Ensembl.
DR   GO; GO:0090660; P:cerebrospinal fluid circulation; IEA:Ensembl.
DR   GO; GO:0044782; P:cilium organization; IEA:Ensembl.
DR   GO; GO:0045198; P:establishment of epithelial cell apical/basal polarity; IEA:Ensembl.
DR   GO; GO:0051683; P:establishment of Golgi localization; IEA:Ensembl.
DR   GO; GO:0010761; P:fibroblast migration; IEA:Ensembl.
DR   GO; GO:0022612; P:gland morphogenesis; IEA:Ensembl.
DR   GO; GO:0034635; P:glutathione transport; IEA:Ensembl.
DR   GO; GO:0030643; P:intracellular phosphate ion homeostasis; IEA:Ensembl.
DR   GO; GO:0045199; P:maintenance of epithelial cell apical/basal polarity; IEA:Ensembl.
DR   GO; GO:0030033; P:microvillus assembly; IEA:Ensembl.
DR   GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR   GO; GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
DR   GO; GO:0010764; P:negative regulation of fibroblast migration; IEA:Ensembl.
DR   GO; GO:0045930; P:negative regulation of mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:0051898; P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR   GO; GO:0010642; P:negative regulation of platelet-derived growth factor receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0010766; P:negative regulation of sodium ion transport; IEA:Ensembl.
DR   GO; GO:0007097; P:nuclear migration; IEA:Ensembl.
DR   GO; GO:0060158; P:phospholipase C-activating dopamine receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0007009; P:plasma membrane organization; IEA:Ensembl.
DR   GO; GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IEA:Ensembl.
DR   GO; GO:0072659; P:protein localization to plasma membrane; IEA:Ensembl.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:Ensembl.
DR   GO; GO:0008361; P:regulation of cell size; IEA:Ensembl.
DR   GO; GO:1903402; P:regulation of renal phosphate excretion; IEA:Ensembl.
DR   GO; GO:0097291; P:renal phosphate ion absorption; IEA:Ensembl.
DR   GO; GO:0003096; P:renal sodium ion transport; IEA:Ensembl.
DR   GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
DR   CDD; cd00992; PDZ_signaling; 2.
DR   Gene3D; 2.30.42.10; -; 2.
DR   InterPro; IPR015098; EBP50_C.
DR   InterPro; IPR017300; NHERF-1/NHERF-2.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   PANTHER; PTHR14191:SF7; NA(+)/H(+) EXCHANGE REGULATORY COFACTOR NHE-RF1; 1.
DR   PANTHER; PTHR14191; PDZ DOMAIN CONTAINING PROTEIN; 1.
DR   Pfam; PF09007; EBP50_C; 1.
DR   Pfam; PF00595; PDZ; 2.
DR   PIRSF; PIRSF037866; EBP50; 1.
DR   SMART; SM00228; PDZ; 2.
DR   SUPFAM; SSF50156; PDZ domain-like; 2.
DR   PROSITE; PS50106; PDZ; 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|PIRNR:PIRNR037866};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225}.
FT   DOMAIN          14..94
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          154..234
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   REGION          114..147
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          277..358
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        286..322
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        331..348
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   358 AA;  38729 MW;  48322A4206D6A51A CRC64;
     MSADAAAGAP LPRLCCLEKG PNGYGFHLHG EKGKVGQYIR LVEPGSPAEK AGLLAGDRLV
     EVNGENVEKE THQQVVSRIR AALNAVRLLV VDPETDEQLQ KLGVQVREEL LRTQEAPGKA
     ESPAAAEAQG AGNENEPSEA DKSHPEQCEL RPRLCTMKKG PNGYGFNLHS DKSKPGQFIR
     SVDADSPAEA SGLRAQDRIV EVNGVCMEGK QHGDVVSAIR AGGDVTKLLV VDRETDEFFK
     KCKVTPSQEH LNGPLPEPFT NGEIQKENSR EALAEAALES PRPALVRTAS SDTSEELNSQ
     DSPPKQDSTV PSSTSSSDPI LDFNISLAVA KERAHQKRSS KRAPQMDWSK KNELFSNF
//
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