ID F7FF75_ORNAN Unreviewed; 1161 AA.
AC F7FF75;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=SEC24 homolog B, COPII coat complex component {ECO:0000313|Ensembl:ENSOANP00000021886.4};
GN Name=SEC24B {ECO:0000313|Ensembl:ENSOANP00000021886.4};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000021886.4, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000021886.4, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000021886.4,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000021886.4}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000021886.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Cytoplasmic vesicle, COPII-coated
CC vesicle membrane {ECO:0000256|ARBA:ARBA00004299}; Peripheral membrane
CC protein {ECO:0000256|ARBA:ARBA00004299}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004299}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004397}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004397}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004397}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
CC {ECO:0000256|ARBA:ARBA00008334}.
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DR AlphaFoldDB; F7FF75; -.
DR STRING; 9258.ENSOANP00000021886; -.
DR Ensembl; ENSOANT00000021889.4; ENSOANP00000021886.4; ENSOANG00000013878.4.
DR eggNOG; KOG1985; Eukaryota.
DR GeneTree; ENSGT00950000182924; -.
DR HOGENOM; CLU_004589_2_0_1; -.
DR TreeFam; TF354244; -.
DR Proteomes; UP000002279; Chromosome 12.
DR Bgee; ENSOANG00000013878; Expressed in ovary and 7 other cell types or tissues.
DR GO; GO:0030127; C:COPII vesicle coat; IEA:InterPro.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd01479; Sec24-like; 1.
DR Gene3D; 2.60.40.1670; beta-sandwich domain of Sec23/24; 1.
DR Gene3D; 1.20.120.730; Sec23/Sec24 helical domain; 1.
DR Gene3D; 3.40.20.10; Severin; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR036180; Gelsolin-like_dom_sf.
DR InterPro; IPR006900; Sec23/24_helical_dom.
DR InterPro; IPR036175; Sec23/24_helical_dom_sf.
DR InterPro; IPR006896; Sec23/24_trunk_dom.
DR InterPro; IPR012990; Sec23_24_beta_S.
DR InterPro; IPR041742; Sec24-like_trunk_dom.
DR InterPro; IPR036465; vWFA_dom_sf.
DR InterPro; IPR006895; Znf_Sec23_Sec24.
DR PANTHER; PTHR13803:SF42; PROTEIN TRANSPORT PROTEIN SEC24B; 1.
DR PANTHER; PTHR13803; SEC24-RELATED PROTEIN; 1.
DR Pfam; PF00626; Gelsolin; 1.
DR Pfam; PF08033; Sec23_BS; 1.
DR Pfam; PF04815; Sec23_helical; 1.
DR Pfam; PF04811; Sec23_trunk; 1.
DR Pfam; PF04810; zf-Sec23_Sec24; 1.
DR SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 2.
DR SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 1.
DR SUPFAM; SSF81811; Helical domain of Sec23/24; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 495..531
FT /note="Zinc finger Sec23/Sec24-type"
FT /evidence="ECO:0000259|Pfam:PF04810"
FT DOMAIN 568..807
FT /note="Sec23/Sec24 trunk"
FT /evidence="ECO:0000259|Pfam:PF04811"
FT DOMAIN 812..896
FT /note="Sec23/Sec24 beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF08033"
FT DOMAIN 907..1007
FT /note="Sec23/Sec24 helical"
FT /evidence="ECO:0000259|Pfam:PF04815"
FT DOMAIN 1034..1106
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT REGION 1..385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 395..414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..179
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..315
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 363..385
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1161 AA; 125890 MW; A7F074351A1D298A CRC64;
MLVQRLQRGP GLNPLQSAPG YGFHPPNSAA PPSGPSSSQM ARKTSPLQPD GQYVPDYYSA
RYPAPTQHVV APPPPHPVGS GAVHTAAGSR QAYGRGPPAH LHASAPHPYT APGNHYGGPA
AHSAAPAMAP QGFPSSSGQP AAAHPSVPYP SVPPGNPYGP GFTSQSASLT RQLPENSFPG
QNAAVAHPPN ATVAHPPRQQ QQQHPPPQRS LGYGASSWPA SGVQSSQDDL LRNHTGSVAA
AGNSSNTVAG SPSRPTNQSV QRPKACPASS SGKPQAAPGQ QPTQPGAPLS HPSDPSVQEA
IDSSSTTSSA SPVPNNYDAL EGGGYPETLS SPTSSPAPAP STPQPAKTSK PFGYGYPTLQ
PGYQNAAPLS SGTQPSNPGY HSGFQQYAQQ YPGMNQLSSS LGGLSLQHSQ QPESLRPVNL
TQDRNILPTT PVLAPVPNLN ADLKKLNCSP DSFRCTLTNI PQTQALLNKA KLPLGLLLHP
FRDLTQLPVI TSSTIVRCRS CRTYINPFVS FIDQRRWKCN LCYRVNDVPE EFMYNPLSRS
YGEPHKRPEV QNSTVEFIAS SDYMLRPPQP AVYLFVLDVS HNAVEAGYLN IVCQSLLENL
DKLPGDSRTR IGFVTFDSTV QFYNLQEGLS QPQMLVVSDI EDIFLPTPDS LLVNLHESKE
LIKDLLNALP NMFTNTRETH SALGPALQAA FKLMSPTGGR VSVFQTQLPS LGVGLLQSRE
DPNQRSSTKV VQHLGPATDF YKKLALDCSG QQTAVDLFLL SSQYSDLASL ACMSKYSAGC
IYYYPSFHHS HNPAQAEKLQ KDLKRYLTRK IGFEAVMRIR CTKGLSIHTF HGNFFVRSTD
LLSLANINPD AGFAVQMSIE ESLADTSLVC FQTALLYTSS KGERRIRVHT LCLPVVSALA
DVYAGVDVQA AICLLANMAV DRSVSSSLSD ARDALVNAVV DSLSAYSSTV SNWQQSAVIA
PSSLKLFPLY VLALLKQKAF RTGTSTRLDD RVFAMCQMKS QPLVHLMKMI HPNLYRVDRL
TDESSIHVND RVVPQPPLQK LSAEKLTREG AFLMDCGSVF YIWIGKSCDT NFIKDVLGYP
NSASVPQKLT HLPELDTLPS ERARSFLSWL RDSRPLSPIL HVVKDESPAK TEFFHHLVED
RTEAAFSYYE FLLHVQQQLC K
//
