ID F7FFW1_ORNAN Unreviewed; 1448 AA.
AC F7FFW1;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Adhesion G protein-coupled receptor B2 {ECO:0000313|Ensembl:ENSOANP00000019556.4};
GN Name=ADGRB2 {ECO:0000313|Ensembl:ENSOANP00000019556.4};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000019556.4, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000019556.4}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000019556.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR STRING; 9258.ENSOANP00000019556; -.
DR Ensembl; ENSOANT00000019559.4; ENSOANP00000019556.4; ENSOANG00000012360.4.
DR eggNOG; ENOG502QRKJ; Eukaryota.
DR GeneTree; ENSGT00940000160103; -.
DR OMA; GNILMPM; -.
DR TreeFam; TF331634; -.
DR Proteomes; UP000002279; Unplaced.
DR Bgee; ENSOANG00000012360; Expressed in brain and 5 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0016525; P:negative regulation of angiogenesis; IEA:InterPro.
DR Gene3D; 1.25.40.610; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR043838; AGRB_N.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR008077; GPCR_2_brain_angio_inhib.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR10239:SF32; ADHESION G PROTEIN-COUPLED RECEPTOR B2; 1.
DR PANTHER; PTHR10239; ISTHMIN-2; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF19188; AGRB_N; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF02793; HRM; 1.
DR Pfam; PF00090; TSP_1; 2.
DR PRINTS; PR01694; BAIPRECURSOR.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00008; HormR; 1.
DR SMART; SM00209; TSP1; 2.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50092; TSP1; 2.
PE 4: Predicted;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1448
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5028348450"
FT TRANSMEM 881..902
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 914..935
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 947..971
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 983..1001
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1021..1044
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1102..1123
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1129..1153
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 492..562
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 877..1154
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 249..272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1315..1335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1347..1376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1448 AA; 158567 MW; 954C29DCF652F122 CRC64;
MNPACPLLLS VIPSLLWLTS AFDPAPSACS ALASGVLYGS FSLQDLFPTI ASGCSWTLEN
PDPTKYSLYL RFNREEQVCA HFAPMVLPLD HYLANFTCSQ DGEWPREEGG GLELCRPRSP
FTFLHFDKNF VQLCLSAEPS EAPRLLAPAA LQFRFVEVLL INNNNSSQFS CAVLCRWVEE
CGHLAARGCA LAQPGWGLQT RQAPSLVCRH CRACSLCPHQ PKPLPPPLVT AVEQIAGVMA
CSREAGAEAC SADHQRPRSR PPPGQLGSGE SPMPYPIPNT CPSLLGDPAA EEWSQWSVCS
LTCGQGLQVR TRSCVSSPYG TLCSGPLREA RTCNNTATCP GTSCANLPAS PHCSRQPTSL
RQGSGPRIGS VDRGCLMSSP PQPHTVPSDQ SPVILRGQQP THWCPWRGWG CGHRTGVLGC
PCVFLNVHTC PECWGICVCP QMCTPDGKWG PWNPWSLCSK TCDTGWQRRF RMCQGTGVQG
YPCEGTGEEV KTCNEKKCPA FYEMCKDEYV MLMTWKKTAA GEIIYNKCPP NATGSASRRC
LLNAQGVAYW GLPSFARCIS HEYRYLHLSV GAHRACPLAP GWGQQRRWGG RAEQPDAPKF
LGREWQQSVG VGFLPLSVWG RRGAHACLPS PCSSSPFSPP SHSLQRFFQV VSYMVDAENK
EKWDDAQQVT PGSVHLLRVV EDFIHLVGDA LKAFQSSLIV TDNLVISIQR EPVSAVSSDI
TFPMRGRRGM KDWARHSEDR LFLPKEVLSL ASSEADESSY FVIGAVLYRT LGLILPQPRP
PLAVSSRVLT VTVRPPTKPT EPLITVELSY VVNVIKTPGG RDPGGWGDAS SGHWDTESCQ
TLESHAAHTR CQCQQLSTFA VLAQMPKDLT LDPSGTPSVP LMIGCAVSCM ALLTLMAVYA
AFWRFIKSER SIILLNFCAS ILASNVLILV GQSQMLSKGA CTLTAAFLHF FFLSSFCWVL
TEAWQSYLAV IGRIRPRLIR KRFLCLGWGL PALVVAVSVG FTRTKGYGTA SYCWLSLEGG
LLYAFVGPAA VIVLVNMLIG IIVFNKLMSR DGVSDKTKKQ RAGYDVPHPP ARTRLLLPCA
ACGVVPSPLL STAAARNAMA SLWSSCVVLP LLALTWMSAV LAMTDRRSIL FQVLFAIFNS
AQGFVIVAVH CFLRREVQDV VKCQIGVCKS DENENSPDSC KNGQVQIMSD FEKDVDLACQ
TVLFKEVNTC NPSTITGTLS RLSLDEDEEP KLHVGSEGSL GFSSLPGNIP PPGILVQGPS
PVLGEPARPE DVSPMYMCGE GSLHQLDYAW LRGAEPRAEG DYAVLPRRTL SLKPFGREEG
KRARAGEGTP RRGPQGLAYE TLQNPYGLHF QPPASGRQAP APGERSRTMP RTVPGSALKL
GSLERKKLRY SDLDFEKVMH TRKRHSELYH ELNQKFHTFD HYRGPSTAKV RVYRRVLLTS
HPQDAASP
//
