ID F7FG95_MACMU Unreviewed; 1286 AA.
AC F7FG95;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Protein phosphatase 1 regulatory subunit 13B {ECO:0000313|Ensembl:ENSMMUP00000023817.3};
GN Name=PPP1R13B {ECO:0000313|Ensembl:ENSMMUP00000023817.3,
GN ECO:0000313|VGNC:VGNC:76259};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000023817.3, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000023817.3}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000023817.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR SMR; F7FG95; -.
DR STRING; 9544.ENSMMUP00000023817; -.
DR Ensembl; ENSMMUT00000025458.4; ENSMMUP00000023817.3; ENSMMUG00000018123.4.
DR VEuPathDB; HostDB:ENSMMUG00000018123; -.
DR VGNC; VGNC:76259; PPP1R13B.
DR eggNOG; KOG0515; Eukaryota.
DR GeneTree; ENSGT00940000153463; -.
DR HOGENOM; CLU_008234_0_0_1; -.
DR InParanoid; F7FG95; -.
DR OMA; GFQSHNG; -.
DR TreeFam; TF105545; -.
DR Proteomes; UP000006718; Chromosome 7.
DR Bgee; ENSMMUG00000018123; Expressed in spermatid and 21 other cell types or tissues.
DR ExpressionAtlas; F7FG95; baseline and differential.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0002039; F:p53 binding; IBA:GO_Central.
DR GO; GO:0072332; P:intrinsic apoptotic signaling pathway by p53 class mediator; IEA:Ensembl.
DR GO; GO:0045786; P:negative regulation of cell cycle; IEA:InterPro.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd17224; RA_ASPP1; 1.
DR CDD; cd11954; SH3_ASPP1; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR047163; ASPP1/2.
DR InterPro; IPR028319; ASPP1_RA.
DR InterPro; IPR048942; ASPP2-like_RA.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR24131; APOPTOSIS-STIMULATING OF P53 PROTEIN; 1.
DR PANTHER; PTHR24131:SF5; APOPTOSIS-STIMULATING OF P53 PROTEIN 1; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF21801; ASPP2-like_RA; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00248; ANK; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT REPEAT 1116..1148
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1149..1181
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 1215..1277
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 28..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 87..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 244..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 535..919
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 931..999
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1030..1077
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 289..357
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 382..460
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 87..105
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..153
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..275
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 549..599
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..628
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 697..720
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 721..738
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 762..795
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 811..837
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 938..967
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1039..1055
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1286 AA; 141737 MW; 274D938E20446BA1 CRC64;
MPTARPPLPR RRERGRARTW LPLRARVAGG VGKPRPSLRP RFRRANQRGR RAPCGAPRWG
RGLRGLKSEL GGREAVGLGL RLRRRWRPGA RDSDAARRRP PQGRREPRSP PQPAAAAASP
RPGRRAQRRE RGLRRRPERR AQLSAERPVR RRPRVPRTLP AMMPMILTVF LSNNEQILTE
VPITPETTCR DVVEFCKEPG EGSCHLAEVW RGNERPIPFD HMMYEHLQKW GPRREEVKFF
LRHEDSPTEN SEQGGRQTQE QRTQRNVTSV PGEKRTENGV GNPRVELTLS ELQDMAARQQ
QQIENQQQML VAKEQRLHFL KQQERRQQQS ISENEKLQKL KERVEAQENK LKKIRAMRGQ
VDYSKIMNGN LSAEIERFSA MFQEKKQEVQ TAILRVDQLS QQLEDLKKGK LNGFQSYNGK
LTGPAAVELK RLYQELQIRN QLNQEQNSKL QQQKELLNKR NMEVAMMDKR ISELRERLYG
KKIQLNRVNG TSSPQSPLST SGRVAAVGPY IQVPSAGSFP VLGDPIKPQS LSIASNAAHG
RSKSDGHSKP RVTSSWTVSD LDVGPNYGSS RPSASPFVNP NDGNWPTLKQ NSSSSVKPVQ
VAGADWKDPS LEGSVKQGTV SSQPVPFSAL GTAEKPGTEM GKVPPPIPGV GKQLPPSYGT
YPSPTPLGPG STSSLERRKE GSLPRPNAGL PSRQRPTLLP PTGSAPQPGS SQQIQQRISV
PPSPTYPPAG PPAFPAGDSK PELPLTVAIR PFLADKGSRP QSPRKGPQTV NSSSIYSMYL
QQATPPKNYQ PAAHSALNKS VKAVYGKPVL PSGSTSPSPL PFLHGSLSMG TPQPQPPSES
AEKEPEQDGP AAPTDGSTVE SLPRPLSPTK LTPIVHSPLR YQSDADLEAL RRKLANAPRP
LKKRSSITEP EGPGGPNIQK LLYQRFNTLA GGMEGTPFYQ PSPSQDFMGT LADVDNGNTN
ANGNLEEPPP AQPTAPLPAE PAPSSDANDN ELPSPEPEEL ICPQTTYQTA ELAEDNNNNV
ATVPSTEQIP SPVVEAPSPG EEQVPPAPLP PASHPPATST SKRTNLKKPN SERTGHGLRV
RFNPLALLLD ASLEGEFDLV QRIIYEVEDP SKPNDEGITP LHNAVCAGHH HIVKFLLDFG
VNVNAADSDG WTPLHCAASC NSVHLCKQLV ESGAAIFAST ISDIETAADK CEEMEEGYIQ
CSQFLYGVQE KLGVMNKGVV YALWDYEAQN SDELSFHEGD ALTILRRKDE SETEWWWARL
GDREGYVPKN LLGLYPRIKP RQRTLA
//
