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Database: UniProt
Entry: F7FH70_ORNAN
LinkDB: F7FH70_ORNAN
Original site: F7FH70_ORNAN 
ID   F7FH70_ORNAN            Unreviewed;       478 AA.
AC   F7FH70;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   16-OCT-2019, entry version 62.
DE   SubName: Full=ETS proto-oncogene 1, transcription factor {ECO:0000313|Ensembl:ENSOANP00000019169};
GN   Name=ETS1 {ECO:0000313|Ensembl:ENSOANP00000019169};
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000019169, ECO:0000313|Proteomes:UP000002279};
RN   [1] {ECO:0000313|Ensembl:ENSOANP00000019169}
RP   IDENTIFICATION.
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000019169};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Transcription factor. {ECO:0000256|PIRNR:PIRNR001698}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR001698,
CC       ECO:0000256|RuleBase:RU004019, ECO:0000256|SAAS:SAAS00594387}.
CC   -!- SIMILARITY: Belongs to the ETS family.
CC       {ECO:0000256|PIRNR:PIRNR001698, ECO:0000256|RuleBase:RU004019,
CC       ECO:0000256|SAAS:SAAS00594391}.
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DR   STRING; 9258.ENSOANP00000019169; -.
DR   Ensembl; ENSOANT00000019172; ENSOANP00000019169; ENSOANG00000012104.
DR   eggNOG; KOG3806; Eukaryota.
DR   eggNOG; ENOG410Z0ZF; LUCA.
DR   GeneTree; ENSGT00940000159519; -.
DR   InParanoid; F7FH70; -.
DR   OMA; TDMECAD; -.
DR   TreeFam; TF316214; -.
DR   Proteomes; UP000002279; Unplaced.
DR   Bgee; ENSOANG00000012104; Expressed in 7 organ(s), highest expression level in heart.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005667; C:transcription factor complex; IEA:Ensembl.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0048870; P:cell motility; IEA:Ensembl.
DR   GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR   GO; GO:0030578; P:PML body organization; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0043536; P:positive regulation of blood vessel endothelial cell migration; IEA:Ensembl.
DR   GO; GO:0045648; P:positive regulation of erythrocyte differentiation; IEA:Ensembl.
DR   GO; GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl.
DR   GO; GO:1904996; P:positive regulation of leukocyte adhesion to vascular endothelial cell; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0061614; P:pri-miRNA transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd08542; SAM_PNT-ETS-1; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR041886; SAM_PNT-ETS-1.
DR   InterPro; IPR016311; Transform_prot_C-ets.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PIRSF; PIRSF001698; Transforming_factor_C-ets; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002279};
KW   DNA-binding {ECO:0000256|PIRNR:PIRNR001698,
KW   ECO:0000256|RuleBase:RU004019, ECO:0000256|SAAS:SAAS00594397};
KW   Nucleus {ECO:0000256|PIRNR:PIRNR001698, ECO:0000256|RuleBase:RU004019,
KW   ECO:0000256|SAAS:SAAS00594400};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW   Transcription {ECO:0000256|PIRNR:PIRNR001698};
KW   Transcription regulation {ECO:0000256|PIRNR:PIRNR001698}.
FT   DOMAIN       88    173       PNT. {ECO:0000259|PROSITE:PS51433}.
FT   DOMAIN      372    452       ETS. {ECO:0000259|PROSITE:PS50061}.
FT   REGION        1     20       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS      1     15       Pro-rich. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   478 AA;  54540 MW;  E4E6E53E36CD3FB3 CRC64;
     LDSWYSPPAP PNPWTQRQGL PSVFEDPRMA CGFQPNCYQQ RAGYLLWDGM ATQEVPTGLE
     HCGSDMECAD VPLLTPSSKE MMSQALKATF SGFSKEQQRL GIPKDPRQWT ETHVRDWVMW
     AVSEFSLKGV DFQKFCMNGA ALCALGKDRF LELAPDFVGD ILWEHLEILQ KEDVKPYQVN
     GVNPAYSESR YTSDYFISYG IEHAQCVPPS EFSEPSFITE SYQTLHPISS EELLSLKYES
     DYPSPVILRE PLTDNLQTDY FTIKQEVVTP DNMCMGRTSR GKLGGQDSFE SVESYDSCDR
     LTQSWSSQSS FNSLQRVPSY DSFDSEDYPA ALPSHKPKGT FKDYVRDRAD LNKDKPVIPA
     AALAGYTGSG PIQLWQFLLE LLTDKSCQSF ISWTGDGWEF KLSDPDEVAR RWGKRKNKPK
     MNYEKLSRGL RYYYDKNIIH KTAGKRYVYR FVCDLQSLLG YTPEELHAML DVKPDADE
//
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