ID F7FN79_MACMU Unreviewed; 1715 AA.
AC F7FN79;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=PR/SET domain 2 {ECO:0000313|Ensembl:ENSMMUP00000040589.3};
GN Name=PRDM2 {ECO:0000313|Ensembl:ENSMMUP00000040589.3,
GN ECO:0000313|VGNC:VGNC:76392};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000040589.3, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000040589.3}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000040589.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR SMR; F7FN79; -.
DR STRING; 9544.ENSMMUP00000040589; -.
DR PaxDb; 9544-ENSMMUP00000040589; -.
DR Ensembl; ENSMMUT00000047558.3; ENSMMUP00000040589.3; ENSMMUG00000017040.4.
DR VEuPathDB; HostDB:ENSMMUG00000017040; -.
DR VGNC; VGNC:76392; PRDM2.
DR eggNOG; KOG2461; Eukaryota.
DR GeneTree; ENSGT00940000159410; -.
DR HOGENOM; CLU_002916_1_0_1; -.
DR InParanoid; F7FN79; -.
DR OMA; MASRCPS; -.
DR TreeFam; TF332173; -.
DR Proteomes; UP000006718; Chromosome 1.
DR Bgee; ENSMMUG00000017040; Expressed in dorsolateral prefrontal cortex and 22 other cell types or tissues.
DR ExpressionAtlas; F7FN79; baseline.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0042054; F:histone methyltransferase activity; IEA:InterPro.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008340; P:determination of adult lifespan; IEA:Ensembl.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd19188; PR-SET_PRDM2; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 3.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR009170; PRDM2.
DR InterPro; IPR044414; PRDM2_PR-SET.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR16515; PR DOMAIN ZINC FINGER PROTEIN; 1.
DR PANTHER; PTHR16515:SF37; PR DOMAIN ZINC FINGER PROTEIN 2; 1.
DR Pfam; PF21549; PRDM2_PR; 1.
DR Pfam; PF00096; zf-C2H2; 2.
DR Pfam; PF13912; zf-C2H2_6; 2.
DR PIRSF; PIRSF002395; RIZ_SET; 1.
DR SMART; SM00317; SET; 1.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 3.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 6.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 34..147
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 357..379
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 387..409
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 480..503
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1131..1158
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1159..1182
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1188..1211
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1452..1479
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 161..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 402..453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 512..547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 615..655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 727..756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 769..795
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 898..1081
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1242..1262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1475..1573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1586..1609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1622..1648
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..183
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..206
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..295
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 296..327
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 727..744
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 947..963
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 964..1003
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1004..1021
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1043..1081
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1519..1573
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 648
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000256|PIRSR:PIRSR002395-1"
FT CROSSLNK 772
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000256|PIRSR:PIRSR002395-1"
SQ SEQUENCE 1715 AA; 188846 MW; FB0CC2F28577C8B2 CRC64;
MILLFLDLQN TTEPAVATET LAEVPEHVLR GLPEEVRLFP SAVDKTRIGV WATKPILKGK
KFGPFVGDKK KRSQVKNNVY MWEVYYPNLG WMCIDATDPE KGNWLRYVNW ACSGEEQNLF
PLEINRAIYY KTLKPIAPGE ELLVWYNGED NPEIAAAIEE ERASARSKRS SPKSRKGKKK
SQENKNKGNK IQDIQLKTSE PDFTSANMRD SAEGPKEDEE KPSASALEQP ATLQEVPPEL
ATPAPAWEPQ PEPDERLEAA DCEVNDLGEE EEEEEEDEEE DDDDELEEEG EEEASMPNES
SVKEPEIRCD EKPEDLLEEP KTTSEETLED FSEVAPAMQI PRTKEEANGD VFETFMFPCQ
HCERKFTTKQ GLERHMHIHI STINHAFKCK YCGKAFGTQI NRRRHERRHE AGLKRKPSQT
LQPSEDLADG KASGENVTSK DELSPPSLGP DCLIMNSEKA SQDTVNSSVV EENGEVKELH
PCKYCKKVFG THTNMRRHQR RVHERHLIPK GVRRKGGLEE PQPPAEQAQA TQNVYVPSTE
PEEEGEADDV YIMDISSNIS ENLNYYIDGK IQTNNNTSNC DVIEMESASA DLYGINCLLT
PVTVEITQNI KTTQVPVTED LPKEPSGSTN SEAKKRRTAS PPALPKIKAE ADSDPMAPSC
SLSLPLSIST TEAVSFHKEK SVYLSSKLKQ LLQTQDKLTP PAGISATEIA KLGPVCVSAP
ASMLPVTSSR FKRRTSSPPS SPQHSPALRD FGKPSDGKAA WTDAVLTSKK SKLESHSDSP
AWSLSGRDER ETVSPPCFDE YKMSKEWTAS SAFSSVCNQQ PLDLSSGVKQ KTEGTGKTPV
QWESVLDLSV HKKPCSDSEG KEFKENHSVQ PTCSAVKKRK PTTCMLQKVL LNEYNGIDLP
VENPADMTRS PSPCKSLEAQ PDPDLGPDSG FPAPTVESPP DVCPSSPALQ TPTLSSGQLP
PLLIPTDPSS PPPCPPVLTV ATPPPPLLPT VPLPAPSSSA SPHPCPSPLS NATAQSPLPI
LSPTVSPSPS PIPPVESLMS AASPGPPTLS SSSSSSSSSS SFSSSSSSSS PSPPPLSAIS
SVVSSGDNLE ASLPMISFKQ EELENEGLKP REEPQSAAEQ DVVQETFNKN FVCNVCESPF
LSIKDLTKHL SIHAEEWPFK CEFCVQLFKD KTDLSEHRFL LHGVGNIFVC SVCKKEFAFL
CNLQQHQRDL HPDKVCTHHQ FESGTLRPQN FTDPSKAHVE HMQSLPEDPL ETSKEEEELN
DSSEELYTTI KIMASGIKTK DPDVRLGLNQ HYPSFKPPPF QYHHRNPMGI GVTATNFTTH
NIPQTFTTAI RCTKCGKGVD NMPELHKHIL ACASASDKKR YTPKKNPVPL KQTVQPKNGM
VVLDNSGKNA FRRMGQPKRL NFSVELSKMS SNKLKLNALK KKNQLVQKAI LQKNKSAKQK
ADLKNACESS SHICPYCNRE FTYIGSLNKH AAFSCPKKPL SPPKKKVSHS SKKGGHSSPA
SSDKNSNSNH RRRTADAEIK MQSMQTPLGK TRARSSGPTQ VPLPSSSFRS KQNVKFAASV
KSKKPSSSSL RNSSPIRMAK ITHVEGKKPK AVAKNHSAQL SSKTSRSLHV RVQKSKAILQ
SKSTLASKRR TDRFNIKSRE RSGGPVTRSL QLAAAADLSE NKREDGSAKQ ELKDFSYSLR
LASRCSPPAA PYITRQCRKV KAPAAAQFQG PFFKE
//
