ID F7FRU2_MACMU Unreviewed; 504 AA.
AC F7FRU2;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Spermatogenesis-defective protein 39 homolog {ECO:0000256|ARBA:ARBA00019368};
DE AltName: Full=VPS33B-interacting protein in apical-basolateral polarity regulator {ECO:0000256|ARBA:ARBA00029984};
DE AltName: Full=VPS33B-interacting protein in polarity and apical restriction {ECO:0000256|ARBA:ARBA00031270};
GN Name=VIPAS39 {ECO:0000313|Ensembl:ENSMMUP00000017822.4,
GN ECO:0000313|VGNC:VGNC:79246};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000017822.4, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000017822.4}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000017822.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Early endosome {ECO:0000256|ARBA:ARBA00004412}.
CC Endosome {ECO:0000256|ARBA:ARBA00004177}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; F7FRU2; -.
DR SMR; F7FRU2; -.
DR STRING; 9544.ENSMMUP00000017822; -.
DR Ensembl; ENSMMUT00000019027.4; ENSMMUP00000017822.4; ENSMMUG00000013551.4.
DR VEuPathDB; HostDB:ENSMMUG00000013551; -.
DR VGNC; VGNC:79246; VIPAS39.
DR GeneTree; ENSGT00390000013955; -.
DR HOGENOM; CLU_029487_0_0_1; -.
DR InParanoid; F7FRU2; -.
DR OMA; YWNRSSR; -.
DR Proteomes; UP000006718; Chromosome 7.
DR Bgee; ENSMMUG00000013551; Expressed in ileum and 23 other cell types or tissues.
DR ExpressionAtlas; F7FRU2; baseline.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005770; C:late endosome; IEA:Ensembl.
DR GO; GO:0055037; C:recycling endosome; IEA:Ensembl.
DR GO; GO:0099023; C:vesicle tethering complex; IEA:Ensembl.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR GO; GO:0030199; P:collagen fibril organization; IEA:Ensembl.
DR GO; GO:0032963; P:collagen metabolic process; IEA:Ensembl.
DR GO; GO:0008333; P:endosome to lysosome transport; IEA:Ensembl.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0043687; P:post-translational protein modification; IEA:Ensembl.
DR GO; GO:0007034; P:vacuolar transport; IBA:GO_Central.
DR InterPro; IPR040057; Spe-39.
DR InterPro; IPR006925; Vps16_C.
DR PANTHER; PTHR13364; DEFECTIVE SPERMATOGENESIS PROTEIN 39; 1.
DR PANTHER; PTHR13364:SF6; SPERMATOGENESIS-DEFECTIVE PROTEIN 39 HOMOLOG; 1.
DR Pfam; PF04840; Vps16_C; 1.
PE 4: Predicted;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718}.
FT DOMAIN 188..288
FT /note="Vps16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04840"
FT REGION 83..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 134..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 504 AA; 58202 MW; AA20E6AC56ACF841 CRC64;
MNRTKGDEEE YWNSSKFKAF TFDDEDDELS QVSSMLGFRL HRLKESKRAV NSLRDFVDDD
DDDDLERVSW SGEPVGSISW SIKETAGNSG SSHEGREQLK SRNSFSSYAQ LPKPTSTYSL
SSFFRGRTRP GSFQSLSDAL SDTPAKSYAP ELGRPKGEYR DYSNDWSPSD TVRRLRKGKV
CSLERFRSLQ DKLQLLEEAV SMHDGNVITA VLIFLKRTLS KEILFRELEV RQVALRHLIH
FLKEIGDQKL LLDLFRFLDR TEELALSHYR EHLNIQDPDK RKEFLKTCIG LPFSAEDSAH
IQDHYTLLER QIIIEANDRH LESAGQTEIF RKHPRKASIL NMPLVTTLFY SCFYHYTEAE
GTFSSPVNLK KTFKIPDKQY VLTALAARAK LRAWNDVDAL FTTKNWLGYT KKRAPIGFHR
VVEILHKNNA PVQILQEYVN LVEDVDTKLN LATKFKCHDV VIDTCRDLKD RQQLLAYRSK
VDKGSAEEEK IDALLSSSQI RWKN
//
