ID F7FSH7_ORNAN Unreviewed; 277 AA.
AC F7FSH7;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Hepatocyte growth factor {ECO:0000313|Ensembl:ENSOANP00000005514.2};
GN Name=HGF {ECO:0000313|Ensembl:ENSOANP00000005514.2};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000005514.2, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000005514.2}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000005514.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00121}.
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DR AlphaFoldDB; F7FSH7; -.
DR MEROPS; S01.976; -.
DR Ensembl; ENSOANT00000005515.3; ENSOANP00000005514.2; ENSOANG00000003484.4.
DR GeneTree; ENSGT00940000156019; -.
DR HOGENOM; CLU_017565_1_0_1; -.
DR Proteomes; UP000002279; Unplaced.
DR Bgee; ENSOANG00000003484; Expressed in liver and 8 other cell types or tissues.
DR CDD; cd00108; KR; 2.
DR CDD; cd00129; PAN_APPLE; 1.
DR Gene3D; 3.50.4.10; Hepatocyte Growth Factor; 1.
DR Gene3D; 2.40.20.10; Plasminogen Kringle 4; 2.
DR InterPro; IPR000001; Kringle.
DR InterPro; IPR013806; Kringle-like.
DR InterPro; IPR018056; Kringle_CS.
DR InterPro; IPR038178; Kringle_sf.
DR InterPro; IPR003609; Pan_app.
DR PANTHER; PTHR24261:SF8; HEPATOCYTE GROWTH FACTOR; 1.
DR PANTHER; PTHR24261; PLASMINOGEN-RELATED; 1.
DR Pfam; PF00051; Kringle; 2.
DR Pfam; PF00024; PAN_1; 1.
DR PRINTS; PR00018; KRINGLE.
DR SMART; SM00130; KR; 2.
DR SMART; SM00473; PAN_AP; 1.
DR SUPFAM; SSF57414; Hairpin loop containing domain-like; 1.
DR SUPFAM; SSF57440; Kringle-like; 2.
DR PROSITE; PS00021; KRINGLE_1; 2.
DR PROSITE; PS50070; KRINGLE_2; 2.
DR PROSITE; PS50948; PAN; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00121};
KW Kringle {ECO:0000256|ARBA:ARBA00022572, ECO:0000256|PROSITE-
KW ProRule:PRU00121}; Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..277
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5027783109"
FT DOMAIN 31..117
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 121..195
FT /note="Kringle"
FT /evidence="ECO:0000259|PROSITE:PS50070"
FT DOMAIN 199..277
FT /note="Kringle"
FT /evidence="ECO:0000259|PROSITE:PS50070"
FT DISULFID 200..277
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00121"
FT DISULFID 221..260
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00121"
FT DISULFID 249..272
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00121"
SQ SEQUENCE 277 AA; 32181 MW; F12FB5E1C1DE324B CRC64;
MWTTQLVPVL MLHLFLSITI PPSEAQKQRR STLHEFKKTA EITLIKVDRA LYSKAKKLNT
TELCAHRCSK NKGLPFSCKA FAFDKALKRC HWFSFNSMTN AVRKKQDHAF DLYEKKDYIR
NCIIGKGGSY KGTVSVTKSG IKCQPWDSMI PHEHGYRGKD LQENYCRNPR GEEGGPWCFT
SNPEVRHEVC DIPQCSTVEC MTCNGESYRG PMDHTESGKE CQRWDQQTPH RHKFLPERYP
DMGFDDNYCR NPDGKQRPWC YTLDPDTPWE YCAIKTC
//
