GenomeNet

Database: UniProt
Entry: F7FVT9_MACMU
LinkDB: F7FVT9_MACMU
Original site: F7FVT9_MACMU 
ID   F7FVT9_MACMU            Unreviewed;      1790 AA.
AC   F7FVT9;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 2.
DT   28-MAR-2018, entry version 49.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN11A {ECO:0000313|Ensembl:ENSMMUP00000026250};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000026250, ECO:0000313|Proteomes:UP000006718};
RN   [1] {ECO:0000313|Ensembl:ENSMMUP00000026250, ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000026250,
RC   ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
RA   Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
RA   Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
RA   Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
RA   Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
RA   Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
RA   Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
RA   Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
RA   Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
RA   Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
RA   Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
RA   Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
RA   Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
RA   Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
RA   Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
RA   Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
RA   Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
RA   Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
RA   Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
RA   Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
RA   Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
RA   Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
RA   Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
RA   Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
RA   Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
RA   Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
RA   Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque
RT   genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMMUP00000026250}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000026250};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; JSUE03023974; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03023975; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_014986816.1; XM_015131330.1.
DR   STRING; 9544.ENSMMUP00000026250; -.
DR   Ensembl; ENSMMUT00000028057; ENSMMUP00000026250; ENSMMUG00000019962.
DR   GeneID; 695258; -.
DR   KEGG; mcc:695258; -.
DR   CTD; 11280; -.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; F7FVT9; -.
DR   KO; K04843; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000006718; Chromosome 2.
DR   Bgee; ENSMMUG00000019962; -.
DR   ExpressionAtlas; F7FVT9; baseline.
DR   GO; GO:0044299; C:C-fiber; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   GO; GO:0051930; P:regulation of sensory perception of pain; IEA:Ensembl.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028821; Na_channel_a11su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10037:SF210; PTHR10037:SF210; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006718};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00085096};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084820};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084701};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    130    149       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    161    180       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    200    219       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    253    276       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    372    392       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    578    596       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    608    629       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    697    722       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    785    810       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1056   1079       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1091   1110       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1116   1139       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1165   1191       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1284   1307       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1357   1380       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1400   1418       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1430   1448       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1485   1513       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1583   1603       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      128    409       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      578    818       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      828   1050       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1054   1316       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1365   1613       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      407    434       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1790 AA;  204691 MW;  6A4CCAC9F4B6348D CRC64;
     MDDRCYPVIF PDERNFRPFT SDSLAAIEKR IAIQKEKDKS KDKTGEVPHL RPQLDLKASR
     KLPNLYGDIP RELIGKPLED LDPFYRNHKT FMVLNKKRTI YRFSAKRALF IFGPFNSIRS
     LAIRVSVHSL FSMFIIGTVI INCVFMARGP AKNSNSNDTD IAECVFTGIY IFEALIKILA
     RGFILDEFSF LRDPWNWLDS IVIGIAIVSC IPGITIKLLS LRTFRVFRAL KAISVVSRLK
     VIVGALLRSV KKLVNVIILT FFCLSIFALV GQQLFMGSLN LKCISRDCKN ISNLEAYDHC
     FEKKENSTEF KMCGIWMVKS SCSKQYECNH TKSNPDYNYT NFDNFGWSFL AMFRLMTQDS
     WEKLYQQTLR TAGLYSVFFF IVVIFLGSFY LINLTLAVVT MAYEEQNKNV AAEIEAKEKM
     FQEAQQLLKE EKEALVAMGI DRSSLTSLET SYFTPQKRKL FGNKKRKSFF LRESGKGQPP
     GSDSDEDSQK KPQLLEQTKR LSQNLSLDHF DEHRDPLQRQ RALSAVSILT ITMKEQEKSQ
     EPCLPCGENL ASKYLVWNCC PLWLCIKKVL RTVMTDPFTE LAITICIIIN TVFLAMEHHK
     MEASFEKMLN TGNLVFTSIF IAEMCLKIIA LDPYHYFRRG WNIFDSIVAL LSFADVMNIF
     QKRSWPFLRS FRVLRVFKLA KSWPTLNTLI KIIGNSVGAL GSLTVVLVIV IFIFSVVGMQ
     LFGHSFNSQK SAKLCNPTGP TVSCLRHWHM GDFWHSFLVV FRILCGEWIE NMWECMQEAN
     ASSSLCVIVF ILITVIGKLV VLNLFIALLL NSFSNEERNG NLEGQARKTK VQLALDRFRR
     AFCFVRHTLE HFCHKWCRKQ KLPKQKEVTG GCAAQSKDII PLVTEMKRGS ETQEELGILT
     SVPKTLGIRH DRTWLAPLAE EEDDAEFSGE DNAQPITQPE AEQQAYELHQ ENKKPTSQGV
     QNVEIDMFPE DEPHLTIQDP RKKSDVTSIL SECSTIDLQD GFGLLPEMVP EKQPERCLPK
     GFGCCFPCCS MDKRKPHWVI WWNLRKTCYQ IVKHSWFESF IIFVILLSSG ALIFEDVYLK
     DRPKIQELLN CTDIIFTYVF ILEMVLKWVA FGFGKYFTSA WCCLDFIIVI VSVTTLINLK
     ELKSFRTLRA LRPLRALSQF EGMKVVVNAL IGAIPAILNV LLVCLIFWLI FCILGVHFFS
     GKFGKCINGT ESVISYTIIA NKSQCESGNF SWINQKVNFD NVGNAYLALL QVATFKGWMD
     IIYAAVDSRE KEQQPKFESN SLGYIYFVVF IVFGSFFTLN LFIGVIIDNF NQQQKKLGGQ
     DIFMTEEQKK YYNAMKKLGS KKPQKPIPRP LNKCQGLVFD VVTSQIFDII IISLIILNMI
     SMMAESYDQS KAVKSTLDHL NWVFVVIFTL ECLIKIFALR QYYFTNGWNL FDSVVVLISI
     VSTMISTLES QEYIPFPPTL FRIVRLARIG RILRLVRAAR GIRTLLFALM MSLPSLFNIG
     LLLFLIMFIY AILGMNWFSK VNPGSGIDDI FNFETFAGSM LCLFQISTSA GWDSLLSPML
     RSKESCNSSS ENCHLPGIAT SYFVSYIIIS FLIVVNMYIA VILENFNTAT EESEDPLGED
     DFDIFYEVWE KFDPEATQFI EYSALSDFAD ALPEPLRVAK PNKYQFLVMD LPMVSGDRLH
     CMDILFAFTA RVLGGSDGLD SMKAMMEEKF METNPLKKLY EPIVTTTKRK EEERCAAVIQ
     KAFRKYMMKV TKGDQGDQSD LENRPHSPLQ TLCNGDLPSF GVVKGKVHYD
//
DBGET integrated database retrieval system