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Database: UniProt
Entry: F7FW49_ORNAN
LinkDB: F7FW49_ORNAN
Original site: F7FW49_ORNAN 
ID   F7FW49_ORNAN            Unreviewed;      1911 AA.
AC   F7FW49;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   12-SEP-2018, entry version 52.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1F {ECO:0000313|Ensembl:ENSOANP00000021420};
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000021420, ECO:0000313|Proteomes:UP000002279};
RN   [1] {ECO:0000313|Proteomes:UP000002279}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Glennie {ECO:0000313|Proteomes:UP000002279};
RX   PubMed=18464734; DOI=10.1038/nature06936;
RA   Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E.,
RA   Ponting C.P., Grutzner F., Belov K., Miller W., Clarke L.,
RA   Chinwalla A.T., Yang S.P., Heger A., Locke D.P., Miethke P.,
RA   Waters P.D., Veyrunes F., Fulton L., Fulton B., Graves T., Wallis J.,
RA   Puente X.S., Lopez-Otin C., Ordonez G.R., Eichler E.E., Chen L.,
RA   Cheng Z., Deakin J.E., Alsop A., Thompson K., Kirby P.,
RA   Papenfuss A.T., Wakefield M.J., Olender T., Lancet D., Huttley G.A.,
RA   Smit A.F., Pask A., Temple-Smith P., Batzer M.A., Walker J.A.,
RA   Konkel M.K., Harris R.S., Whittington C.M., Wong E.S., Gemmell N.J.,
RA   Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J., Zemann A.,
RA   Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA   Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA   Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA   Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H.,
RA   Taylor J., Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y.,
RA   Huang X., Stark A., Kheradpour P., Kellis M., Flicek P., Chen Y.,
RA   Webber C., Hardison R., Nelson J., Hallsworth-Pepin K., Delehaunty K.,
RA   Markovic C., Minx P., Feng Y., Kremitzki C., Mitreva M., Glasscock J.,
RA   Wylie T., Wohldmann P., Thiru P., Nhan M.N., Pohl C.S., Smith S.M.,
RA   Hou S., Nefedov M., de Jong P.J., Renfree M.B., Mardis E.R.,
RA   Wilson R.K.;
RT   "Genome analysis of the platypus reveals unique signatures of
RT   evolution.";
RL   Nature 453:175-183(2008).
RN   [2] {ECO:0000313|Ensembl:ENSOANP00000021420}
RP   IDENTIFICATION.
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000021420};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   STRING; 9258.ENSOANP00000021420; -.
DR   Ensembl; ENSOANT00000021423; ENSOANP00000021420; ENSOANG00000013580.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   InParanoid; F7FW49; -.
DR   OMA; LNQTECR; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   TreeFam; TF312805; -.
DR   Proteomes; UP000002279; Unplaced.
DR   Bgee; ENSOANG00000013580; Expressed in 3 organ(s), highest expression level in brain.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:Ensembl.
DR   GO; GO:0008331; F:high voltage-gated calcium channel activity; IBA:GO_Central.
DR   GO; GO:0050908; P:detection of light stimulus involved in visual perception; IEA:Ensembl.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   GO; GO:0050856; P:regulation of T cell receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0043029; P:T cell homeostasis; IEA:InterPro.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR031688; CAC1F_C.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR030157; VDCC_L_a1F.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10037:SF184; PTHR10037:SF184; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16885; CAC1F_C; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 5.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002279};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAAS:SAAS00085096, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00084820,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00084701,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     94    113       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    125    145       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    157    175       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    229    252       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    308    329       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    341    363       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    511    530       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    542    560       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    673    690       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    710    732       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    930    956       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    976   1005       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1165   1186       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1192   1213       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1300   1318       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1391   1415       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1549   1583       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
SQ   SEQUENCE   1911 AA;  213827 MW;  96A51508A71F3C7D CRC64;
     MSGSQNGKAL QPHPHPSRPK LSPGPEWGLS LEPRAGGPDH PGSDTPRRRL QHGKHKSQGA
     GGTQRSPRAL FCLSLNNPLR RSCISIVEWK PFDVLILVTI FANCVALGVY IPFPENPNLE
     QVEYVFLIIF TAETCLKIVA YGLVLHPSAY IRNGWNLLDF VIVVVGLFSV LLEQAPNRSR
     DAHHPSGKPG GFDVKALRAF RVLRPLRLVS GVPSLHIVLN SIMKAMVPLL HIALLVLFVI
     IIYAIIGLEL FIGRMHKTCF YVGSELEAEE DPSPCAFSGH GRQCTTNNTE CRGRWAGPNG
     GITNFDNFFF AMLTVFQCIT MEGWTDVLYW MQDAMGHELP WLYFVSLVIF GSFFVLNLVL
     GVLSGEFSKE REKAKARGDF QKLREKQQME EDLRGYLDWI TQAEDLEPDD GQGEEEMAKE
     RRHHRVTLAD LTDKKRSRLH WFSHSTRSAS SHASLPASET ASVTTENTGE EEATGCCATC
     IVKIAKTKVC RWLRRSNRLL RRKCRLAVKS ASFYWMVLLL VFLNTLTIAS EHHNQPPWLT
     QIQAYANKVL LSLFTLEMLL KLYSLGPQAY GVSFFNRFDC FVVCGGILET ALVELDIMQP
     LGISVLRCVR LLRIFKVTRS EPGGGEGLGC CGGLWGQGAG RPESWEVEGL GDCPIPIERK
     GGAVNRWAKR KRMSSLSPFP SFFLPASHIL TGEDWNSVMY DGIMAYGGPF FPGMLVCVYF
     IILFICGNYI LLNVFLAIAV DNLAGGDNIN TSKGQDNPDY LGPPTPPLPH HPQGQEENGG
     EERGRGADAG SWRFGDEGGE EEDSEAESLA ESQLEKLQEV VPKEKVVPIP EGSSFFCLSQ
     TNPWKPLCHV TRHPTHHFFV GLSQAFRTVH CIRWEYCLHS PWLRPLLSLP CLAFPTPLYS
     SQFLRVELQQ MTAFGAFLHK GSFCRNWFNL LDLLVVSVSL ISFGIHSSAI SVVKILRVLR
     VLRPLRAINR AKGLKHVVQC VFVAIRTIGN IMIVTTLLQF MFACIGVQLF KGKFYSCTDE
     AKHNPGECKG TFIVYQDGDV NHPMVRERVW HNSDFNFDNV LAGMMALFTV STFEGWPELT
     ERGTEGKKGP GGVLSRADEG SRRGPPRPHL RIHHRAQGEQ EYKNCELDKN QRQCVEYALK
     AQPLRRYIPK NPTQHRVWAA VNSTAFEYIM FVLILLNTIA LAMQHYEQTA PFNYAMDILN
     MVFTGLFTAE MLLKIIAFKP KHYFCDAWNT FDALIVVGSL VDIAVTEVNN GGHLGESSED
     SSRISITFFR LFRVMRLVKL LSKGEGIRTL LWTFIKSFQA LPYVALLIAM IFFIYAVIGM
     QTFGKVAMQD GTQINRNNNF QTFPQAVLLL FRCATGEAWQ EIMLASLPGK RCDPESDYGP
     GEEFTCGSNF AIVYFISFFM LCAFLIINLF VAVIMDNFDY LTRDWSILGP HHLDEFKRIW
     SEYDPAAKGR IKHLDVVALL RRIQPPLGFG KLCPHRVACK RLVAMNMPLD ADGTVTFNAT
     LFALVRTSLR IKTEGNLDLA NQELRIVIKK IWKRTKPRLL DEVIPTPEEE EVTVGKFYAT
     FLIQDYFRKF RRRKERGLLG SEASPSRSSA LQAGLKSLQD LAPEMRQALS CDLKGGETEG
     QKAESRLAPD NPRPPSRWTS ATSLPLNTGD SEPSTGGPPG SLSSPAASQP RGPRGPGEEE
     EEEEGSPSPG QPMESRLGPH SLRGQEGREE EWSGGGFTRA QTGAETRPGG PCFLPRPFRH
     FSQSRAAGRL DGHRAQRRRL LPPTPAGRKP SFTIQCLRRQ GSCEDMPIPG TYHQNPPPGR
     RRPQNSWANP VPRGRLLYAP LILVEEARGN GWYQEEPEGP YRAYTQLRVP TQRPSGSRGK
     RGSADSLVEA VSLGRPRWKQ GPEGVALPKG KIANPVQLEN EEMENAANDL L
//
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