ID F7FZ50_ORNAN Unreviewed; 1036 AA.
AC F7FZ50;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=Structural maintenance of chromosomes protein 5 {ECO:0000256|ARBA:ARBA00018687};
GN Name=SMC5 {ECO:0000313|Ensembl:ENSOANP00000007970.3};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000007970.3, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000007970.3, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000007970.3,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000007970.3}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000007970.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome, telomere
CC {ECO:0000256|ARBA:ARBA00004574}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SMC family. SMC5 subfamily.
CC {ECO:0000256|ARBA:ARBA00010171}.
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DR AlphaFoldDB; F7FZ50; -.
DR STRING; 9258.ENSOANP00000007970; -.
DR Ensembl; ENSOANT00000007972.3; ENSOANP00000007970.3; ENSOANG00000005025.3.
DR eggNOG; KOG0979; Eukaryota.
DR GeneTree; ENSGT01100000263829; -.
DR TreeFam; TF105708; -.
DR Proteomes; UP000002279; Chromosome X5.
DR Bgee; ENSOANG00000005025; Expressed in fibroblast and 8 other cell types or tissues.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0030915; C:Smc5-Smc6 complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038729; Rad50/SbcC_AAA.
DR InterPro; IPR027131; SMC5.
DR PANTHER; PTHR45916; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5; 1.
DR PANTHER; PTHR45916:SF1; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5; 1.
DR Pfam; PF13476; AAA_23; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chromosome {ECO:0000256|ARBA:ARBA00022895};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Telomere {ECO:0000256|ARBA:ARBA00022895}.
FT DOMAIN 51..252
FT /note="Rad50/SbcC-type AAA"
FT /evidence="ECO:0000259|Pfam:PF13476"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 214..314
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 342..404
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 608..697
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 744..771
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 827..861
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1036 AA; 120114 MW; E6153C4644BDE659 CRC64;
MAAPAKRKPG PAEEPPIPRK QPSAGGSQVP GARRSRRPPS PKWPADGSIV RIAMENFLTY
DTCEVSPGPH LNMIIGANGT GKSSIVCAIC LGLGGKPSFI GRADKVSSFV KHGCNKGLIE
IELFRASGNV VIKREIHIAG NQSSWFVDTK PATQKVVEEL IAGLNIQVGN LCQFLPQDKV
GEFAKLSKIE LLEATEKSIG PPEMYKFHCE LKNFREREKE LEEYEHVRKE HEEAKQKRDS
KKEEIRTLKE AQFPLTQKIS EIDQHSKNLE TQIKETTAAA KETSQKCKEK QDAMERKDKQ
IEESQQALKI KQVQEMARQE RISNTHKMIE DWQSELKNTG SSENLQAQID LVNNDLRCLE
AEKATIDGEI ADQQRERENL EREKQSMTDH IQSLENQMSL KEEKLKGRYP DTYNAIMWLR
KNKDRFKQMV CEPMMLLINM KDNRNAKYVE NHISANDMRA FVFENQDDME TFLQEVRDNQ
HLRVNTVIAP NSSHAAKTPS RSLDELRQYG FFSFLRELFD APQLVMSYLC FHYNIHEVPV
GTDKTRAMIE QVIRETNLKQ IYTAEEKYSL KTSSYSNKII SSNIALKGAQ FLTVSVDADK
KKYLGKQLQE IDRKLQILNT VIKTLREKLS CMEPRGNELR LQKKELLEKK TKKRQLEQKI
ISKQNSLKLM EQDVFNLEEA QQETDAKIRE INIQKTKLVF EQTQLIKTYL KLNIRKMNLV
LQNTNVISEK NKVEAEYKAR SSQLYMLEQQ YVALEEKKRK LLEKCRELLR KAKNVCNLSP
EQSVPVEYQA AFQDLPNTLD EIDVLLAEEK SRASCFTSLT ASVVEEYRKR EQEIQQLTAQ
VKKYEGELDN YRQNITQVKE RWLIPLKQLI GKINEKFSNF FSSMQCAGEV DLHMENEEDY
DKYGIRIRVK FRSNSKLHEL TPHHQSGGER SVSTMLYLMA LQDLNKCPFR VVDEINQGMD
PINERRVFDM VVKTACQEST SQYFFITPKL LQNLNYAEKM TVLFVYNGPY MLEPNKWNLK
AFRRRRKRME DNPLDQ
//
