UniProt: F7FZT0

Database: UniProt
Entry: F7FZT0_CALJA

LinkDB:  F7FZT0_CALJA 
Original site:  F7FZT0_CALJA

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Ontology (8)   
   GO (8)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (3)   
   ENSEMBL-UP (3)   
Protein domain (15)   
   InterPro (10)   
   Pfam (3)   
   SMART (2)   
All databases (27)   

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ID   F7FZT0_CALJA            Unreviewed;      2258 AA.
AC   F7FZT0;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   25-MAY-2022, sequence version 4.
DT   27-MAR-2024, entry version 71.
DE   RecName: Full=DNA polymerase epsilon catalytic subunit {ECO:0000256|RuleBase:RU365029};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU365029};
GN   Name=POLE {ECO:0000313|Ensembl:ENSCJAP00000023741.5};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000023741.5, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000023741.5}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000023741.5}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: DNA polymerase II participates in chromosomal DNA
CC       replication. {ECO:0000256|RuleBase:RU365029}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU365029};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU365029};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU365029}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|ARBA:ARBA00005755, ECO:0000256|RuleBase:RU365029}.
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DR   Ensembl; ENSCJAT00000025115.5; ENSCJAP00000023741.5; ENSCJAG00000012853.5.
DR   eggNOG; KOG1798; Eukaryota.
DR   GeneTree; ENSGT00390000010194; -.
DR   TreeFam; TF105017; -.
DR   Proteomes; UP000008225; Chromosome 9.
DR   Bgee; ENSCJAG00000012853; Expressed in liver and 6 other cell types or tissues.
DR   GO; GO:0008622; C:epsilon DNA polymerase complex; IEA:InterPro.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd05779; DNA_polB_epsilon_exo; 1.
DR   CDD; cd05535; POLBc_epsilon; 1.
DR   Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR   Gene3D; 3.30.342.10; DNA Polymerase, chain B, domain 1; 1.
DR   Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR042087; DNA_pol_B_thumb.
DR   InterPro; IPR013697; DNA_pol_e_suA_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR029703; POL2.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR10670; DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A; 1.
DR   PANTHER; PTHR10670:SF1; DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A; 1.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF08490; DUF1744; 1.
DR   SMART; SM01159; DUF1744; 1.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|ARBA:ARBA00022485, ECO:0000256|RuleBase:RU365029};
KW   DNA replication {ECO:0000256|RuleBase:RU365029};
KW   DNA-binding {ECO:0000256|RuleBase:RU365029};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW   ECO:0000256|RuleBase:RU365029};
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU365029};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014, ECO:0000256|RuleBase:RU365029};
KW   Metal-binding {ECO:0000256|RuleBase:RU365029};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW   ECO:0000256|RuleBase:RU365029};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU365029};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU365029};
KW   Zinc {ECO:0000256|RuleBase:RU365029};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU365029}.
FT   DOMAIN          1498..1898
FT                   /note="DNA polymerase epsilon catalytic subunit A C-
FT                   terminal"
FT                   /evidence="ECO:0000259|SMART:SM01159"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1912..1943
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1921..1943
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2258 AA;  258737 MW;  7D74B45C1D759A38 CRC64;
     MALRSGGRRR ADPGADGEAG RDDGPTSSVS ALKRLERSQW TDKMDLRFGF ERLKEPGEKT
     GWLINMHPVA LPYKPYFYIA TRKGCEREVS SFLSKKFQGK IAKVETVPKE DLDLPNHLVG
     LKRNYIKLSF HTVEDLVKVR KEIFPAVKKN REQDHASDTY TAMLSSVLQR TSVITDEEEA
     SKKIADQLDN IVDMREYDVP YHIRLSIDLK IHVAHWYNVR YRGNAFPVEI TRRDDLVERP
     DPVVLAFDIE TTKLPLKFPD AETDQIMMVS YMIDGQGYLI TNREIVSEDI EDFEFTPKPE
     YEGPFCVFNE PDEAHLIQRW FEHVQETRPT VMVTYNGDFF DWPFVEARAA VHGLSMQQEI
     GFQKDSQGEY KAPQCIHMDC LRWVKRDSYL PVGSHNLKAA AKAKLGYDPV ELDPEDMCRM
     ATEQPQTLAT YSVSDAVATY YLYMKYVHPF IFALCTIIPM EPDEVLRKGS GTLCEALLMV
     QAFHANIIFP NKQEQEFNKL TDDGHVLDSE TYVGGHVEAL ESGVFRSDIP CRFRMNPAAF
     DFLLQRVEKT LRHAIEEEEK VPVEQVTNFQ ELCDQIKSKL ASLKEVPNRI ECPLIYHLDV
     GAMYPNIILT NRLQPSAMVD EATCAACDFN KPGANCQRKM AWQWRGEFMP ASRSEYHRIQ
     HQLESEKFPS LFPEGPARAF HELSREEQAK YEKRRLADYC RKAYKKIHIT KVEERLTTIC
     QRENSFYVDT VRAFRDRRYE FKGLHKVWKK KLSAAVEVGD AAEVKRCKNM EVLYDSLQLA
     HKCILNSFYG YVMRKGARWY SMEMAGIVCF TGANIITQAR ELIEQIGRPL ELDTDGIWCV
     LPNSFPENFV FKTTNVKKPK VTISYPGAML NLMVKEGFTN DQYQELAEPS SLTYVTRSEN
     SIFFEVDGPY LAMILPASKE EGKKLKKRYA VFNEDGSLAE LKGFEVKRRG ELQLIKIFQS
     SVFEAFLKGS TLEEVYASVA KVADYWLDVL YSKAANMPDS ELFELISENR SMSRKLEDYG
     EQKSTSISTA KRLAEFLGDQ MVKDAGLSCR YIISRKPEGS PVTERAIPLA IFQAEPTVRK
     HFLRKWLKSS SLQDFDIRAI LDWDYYIERL GSAIQKIITI PAALQQVKNP VPRVKHPDWL
     HKKLLEKNDV YKQKKISELF TLEGRRQVMM AQAPGDSLRP SAPDMEDFGL VKPPHPPAHI
     AVKRKRVLWE SQEESQDLTP TVPWQEILGQ PPALGTTQEE WLVWLRFHKK KWQLQARQRL
     ARRKRQRLES AEGVPRPGAI RDGPATGLGS FLRRTARSIL DLPWQIVQIS ETSQPGLFRL
     WALIGSDLHC IRLSIPRVFY VNQRVAKAEE GASYRKVNRV LPRSNVVYNL YEYSVPEDMY
     QEHINEINTE LSAPDIEGVY ETQVPLLFRA LVHLGCVCVV NKQLVRHLSG WEAETFALEH
     LEMRSLAQFS YLEPGSIRHI YLYHHMQGHK ALFGIFIPSQ HRASVFVLDT VRSNQMPSLG
     ALYSAEHGLL LEKVGPELLP PPKHTFEVRA ETDLKTICRA IQRFLLAYKE ERRGPTLIAV
     QSNWELKRLA REIPVLEEFP LVPICVADKI NYGVLDWQRH GARRMIRHYL NLDTCLSQAF
     EMSRYFHIPI GNLPEDISTF GSDLFFARHL QRHNHLLWLS PTARPDLGGK EADDNRLVME
     FDDQATVEIN SSGCYSTVCM ELDLQNLAVN TILQSHHVND MEGADSMGIS FDVIQQASLE
     DMITGGQAAS APASYDETAL CSNTFRILKS MVVGWVKEIT QYHNIYADNQ VMHFYRWLRS
     PSSLLYDPAL HRTLHNMMKK LFLQLIAEFK RLGSSVIYAN FNRIILCTKK RRVEDAIAYV
     EYITSSIHSK EIFHSLTISF SRCWEFLLWM DPSNYGGIKG KVSSRIHCGL QDSQKAGGAA
     DEQEDEDEEE EREGEEEDAE ESDVEDLLEN SWNILQFLPQ AASCQSYFLM IVSAYIVAVY
     HCMKDGLRRS APGSTPVRRR GASQLSQEAE ETAGALPGMI TFSQDYVANE LTQSFFTITQ
     KIQKKVTGSR NSAELSEMFP VLPGSHLLLN NPALEFIKYV CKVLSLDTNI TNQVNKLNRD
     LLRLVDVGEF SEEAQFRDPC RSYVLPEVIC RSCNFCRDLD LCKDSSFSED GVVLPQWLCP
     NCQAAYDSSA IEMALVEVLQ KKLMAFTLQD LVCLKCRGVK ETHMPVYCSC AGDFALTIHT
     KVFMEQIRIF QNIAQHYGMS YLLETLEWLL QKNPQLGH
//

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