ID F7G2I9_MACMU Unreviewed; 1054 AA.
AC F7G2I9;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Endoplasmic reticulum metallopeptidase 1 {ECO:0000313|Ensembl:ENSMMUP00000007237.4};
GN Name=ERMP1 {ECO:0000313|Ensembl:ENSMMUP00000007237.4,
GN ECO:0000313|VGNC:VGNC:72322};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000007237.4, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000007237.4}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000007237.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the peptidase M28 family.
CC {ECO:0000256|ARBA:ARBA00010918}.
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DR AlphaFoldDB; F7G2I9; -.
DR SMR; F7G2I9; -.
DR STRING; 9544.ENSMMUP00000007237; -.
DR MEROPS; M28.018; -.
DR PaxDb; 9544-ENSMMUP00000007237; -.
DR Ensembl; ENSMMUT00000007705.4; ENSMMUP00000007237.4; ENSMMUG00000005469.4.
DR VEuPathDB; HostDB:ENSMMUG00000005469; -.
DR VGNC; VGNC:72322; ERMP1.
DR eggNOG; KOG2194; Eukaryota.
DR GeneTree; ENSGT00530000063839; -.
DR HOGENOM; CLU_007536_2_0_1; -.
DR InParanoid; F7G2I9; -.
DR OMA; HFWIEAE; -.
DR TreeFam; TF314836; -.
DR Proteomes; UP000006718; Chromosome 15.
DR Bgee; ENSMMUG00000005469; Expressed in spermatid and 19 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008235; F:metalloexopeptidase activity; IEA:InterPro.
DR GO; GO:0034599; P:cellular response to oxidative stress; IEA:Ensembl.
DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:Ensembl.
DR GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR CDD; cd03875; M28_Fxna_like; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR048024; Fxna-like_M28_dom.
DR InterPro; IPR045175; M28_fam.
DR InterPro; IPR007484; Peptidase_M28.
DR PANTHER; PTHR12147:SF26; ENDOPLASMIC RETICULUM METALLOPEPTIDASE 1; 1.
DR PANTHER; PTHR12147; METALLOPEPTIDASE M28 FAMILY MEMBER; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00023049};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 569..587
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 599..625
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 637..660
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 672..694
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 700..718
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 730..753
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 773..795
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 802..824
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 335..528
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
FT REGION 160..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..176
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1054 AA; 116220 MW; 1DC40F41AAA2638B CRC64;
MVEREALSTD HGSFSFPELR LGASLSKRCC PLAISRPGGR DWKSGESFLF CLKVSFQLAI
SVLQRAGKAL RETAYPPPAA GSARQLCPPE NGQRSWVLAR RDGPIRRSLA LCSFRPLTRR
RCGSVGGGGG GGRGCSGLGL LGWQLRLVAM EWGSESAAVR RHRVGGERRD GPAAAPPPER
EARAQELLVD GCGGGGGRTR KRSLGGSGGA SRGAGTGLSE ARAALGLALY LLALRTLVQL
SLQQLVLRGT AGHHGEFDAL QARDYLEHIT SIGPRTTGSP ENEILTVHYL LEQIKLIEVQ
SNRLHKISVD VQRPTGSFSI DFLGGFTSYY DNITNVVVKL EPRDGAQHAV LANCHFDSVA
NSPGASDDAV SCSVMLEVLR VLSTSSEALH HAVIFLFNGA EENVLQASHG FITQHPWASL
IRAFINLEAA GVGGKELVFQ TGPENPWLVQ AYVSAAKHPF ASVVAQEVFQ SGIIPSDTDF
RIYRDFGNIP GIDLAFIENG YIYHTKYDTA DRILTDSIQR AGDNILAVLK HLATSDMLAA
ASKYRHGNMV FFDVLGLFVI AYPSRIGSII NYMVVMGVIL YLGKKLLQPK HKTGNYKKDF
LCGLGITLIS WFTSLVTVLI IAVFISLIGQ SLSWYNHFYV SVCLYGTATV AKIIFIHTLA
KRFYYMNVSD QYLGEVFFDI ALFVHCCSLV TLTYQGLCSA FISAVWVAFP LLTKLCVHKD
FKQHGAQGKF IAFYLLGMFI PYLYALYLIW AVFEMFTPIL GRSGSEIPPD VVLASILAGC
TMILSSYFIN FIYLAKSTKK TMLTLTLVCA ITFLLVCSGT FFPYSSNPAN PKPKRVFLQH
VTRTFHDLEG NAVKRDSGIW INGFDYTGMS HITPHIPEIN DSIRAHCEEN APLCGFPWYL
PVHFLIRKNW YLPAPEVSPR NPAHFQLISK EQTPWDSIKL TFEATGPSHM SFYVRAHKGS
TLSQWSLGNG TPVTSKGGDY FVFYSHGLQA SAWQFWIEVQ VSEEHPEGMV TVAIAAHYLS
GEDKRSPQLD ALKERFPDWT FPSAWVCTYD LFVF
//
