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Database: UniProt
Entry: F7G413_MACMU
LinkDB: F7G413_MACMU
Original site: F7G413_MACMU 
ID   F7G413_MACMU            Unreviewed;      1070 AA.
AC   F7G413;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 2.
DT   03-JUL-2019, entry version 61.
DE   SubName: Full=Inactive tyrosine-protein kinase 7 isoform a {ECO:0000313|EMBL:AFH28843.1};
GN   Name=PTK7 {ECO:0000313|EMBL:AFH28843.1,
GN   ECO:0000313|Ensembl:ENSMMUP00000033652};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000033652, ECO:0000313|Proteomes:UP000006718};
RN   [1] {ECO:0000313|Ensembl:ENSMMUP00000033652, ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000033652,
RC   ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
RA   Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
RA   Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
RA   Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
RA   Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
RA   Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
RA   Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
RA   Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
RA   Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
RA   Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
RA   Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
RA   Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
RA   Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
RA   Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
RA   Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
RA   Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
RA   Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
RA   Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
RA   Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
RA   Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
RA   Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
RA   Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
RA   Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
RA   Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
RA   Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
RA   Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
RA   Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque
RT   genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMMUP00000033652}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000033652};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000313|EMBL:AFH28843.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Orbital {ECO:0000313|EMBL:AFJ70731.1}, Testis
RC   {ECO:0000313|EMBL:AFI33474.1}, and Thymus
RC   {ECO:0000313|EMBL:AFH28843.1};
RX   PubMed=25319552; DOI=10.1186/1745-6150-9-20;
RA   Zimin A.V., Cornish A.S., Maudhoo M.D., Gibbs R.M., Zhang X.,
RA   Pandey S., Meehan D.T., Wipfler K., Bosinger S.E., Johnson Z.P.,
RA   Tharp G.K., Marcais G., Roberts M., Ferguson B., Fox H.S.,
RA   Treangen T., Salzberg S.L., Yorke J.A., Norgren R.B.Jr.;
RT   "A new rhesus macaque assembly and annotation for next-generation
RT   sequencing analyses.";
RL   Biol. Direct 9:20-20(2014).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC       kinase family. {ECO:0000256|SAAS:SAAS00602168}.
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DR   EMBL; JSUE03030913; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03030914; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03030915; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03030916; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03030917; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03030918; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JU472039; AFH28843.1; -; mRNA.
DR   EMBL; JV043403; AFI33474.1; -; mRNA.
DR   EMBL; JV635391; AFJ70731.1; -; mRNA.
DR   RefSeq; NP_001248508.1; NM_001261579.1.
DR   STRING; 9544.ENSMMUP00000033655; -.
DR   Ensembl; ENSMMUT00000040605; ENSMMUP00000033652; ENSMMUG00000011670.
DR   GeneID; 699791; -.
DR   KEGG; mcc:699791; -.
DR   CTD; 5754; -.
DR   eggNOG; KOG1026; Eukaryota.
DR   eggNOG; KOG4475; Eukaryota.
DR   eggNOG; COG0515; LUCA.
DR   GeneTree; ENSGT00940000157908; -.
DR   KO; K05127; -.
DR   OMA; GISHKGV; -.
DR   OrthoDB; 530072at2759; -.
DR   TreeFam; TF326835; -.
DR   Proteomes; UP000006718; Chromosome 4.
DR   Bgee; ENSMMUG00000011670; Expressed in 13 organ(s), highest expression level in lung.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 7.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   Pfam; PF07679; I-set; 3.
DR   Pfam; PF07714; Pkinase_Tyr; 1.
DR   PRINTS; PR00109; TYRKINASE.
DR   SMART; SM00409; IG; 7.
DR   SMART; SM00408; IGc2; 7.
DR   SUPFAM; SSF48726; SSF48726; 7.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS50835; IG_LIKE; 7.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006718};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS01150976};
KW   Immunoglobulin domain {ECO:0000256|SAAS:SAAS00941986};
KW   Kinase {ECO:0000313|EMBL:AFH28843.1};
KW   Membrane {ECO:0000256|SAAS:SAAS00602125, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|SAAS:SAAS00600436};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW   Repeat {ECO:0000256|SAAS:SAAS00295312};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000313|EMBL:AFH28843.1};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00600943,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00602683,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     30       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        31   1070       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014090948.
FT   TRANSMEM    705    726       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       15    120       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      128    218       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      225    301       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      309    407       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      412    497       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      506    575       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      576    680       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      796   1070       Protein kinase. {ECO:0000259|PROSITE:
FT                                PS50011}.
FT   REGION      736    759       Disordered. {ECO:0000256|MobiDB-lite:
FT                                F7G413}.
FT   REGION      773    793       Disordered. {ECO:0000256|MobiDB-lite:
FT                                F7G413}.
FT   REGION     1049   1070       Disordered. {ECO:0000256|MobiDB-lite:
FT                                F7G413}.
FT   COMPBIAS   1053   1070       Polar. {ECO:0000256|MobiDB-lite:F7G413}.
SQ   SEQUENCE   1070 AA;  118466 MW;  E6738DDBC1C81C5E CRC64;
     MGATRGSLAR PRRLPLLSVL LLPLLGGTQA AIVFIKQPSS QDALQGRRAL LRCEVEAPGL
     VHVYWLLDGA PVQDTERRFT QGSSLSFAAV DRLQDSGTFQ CVARDDVTGE EARSANASFN
     IKWIEAGPVV LKHPASEAEI QPQTQVTLRC HIDGHPRPTY QWFRDGTPLS DGQSNNTVSS
     KERNLTLRPA GPEHSGLYSC CAHNAFGQAC SSQNFTLSIA DESFARVVLA PQDVIVARNE
     EAMFHCQFSA QPPPNLQWLF EDETPITNRS RPPHLRRATV FANGSLLLTQ VRPRNAGVYR
     CIGQGQRGPP VILEATLHLA EIEDMPLFEP RVFTAGSEER VTCLPPKGLP EPSVWWEHAG
     VRLPTHGRVY QKGHELVLAS IAESDAGVYT CHAANLAGQR RQDVNITVAT VPTWLKKPQD
     SQLEEGKPGY LHCLTQATPK PTVVWYRNQM LISEDSRFEV FKNGTLRINN VEVYDGTWYR
     CVSSTPAGSI EAQARVQVLE KLKFTPPPQP QQCMEFDKEA TVPCSATGRE KPTIKWERAD
     GSSLPEWVTD NAGTLHFARV TRDDAGNYTC IASNGPQGQI RAHVQLTVAV FITFKVEPER
     TTVYQGHTAL LQCEAQGDPK PLIQWKGKDR ILDPTKLGPR MHIFQNGSLV IHDVAPEDSG
     RYTCIAGNSC NIKHTEAPLY VVDKPVPEES EGPGSPPPYK MIQTIGLSVG AAVAYIIAVL
     GLMFYCKKRC KAKRLQKQPE GEEPEMECLN GGPLQNGQPS AEIQEEVALT SLGSGPTATN
     KRHSTSDKMH FPRSSLQPIT TLGKSEFGEV FLAKAQGLEE GVAETLVLVK SLQSKDEQQQ
     LDFRRELEMF GKLNHANVVR LLGLCREAEP HYMVLEYVDL GDLKQFLRIS KSKDEKLKSQ
     PLSTKQKVAL CTQVALGMEH LSNNRFVHKD LAARNCLVSA QRQVKVSALG LSKDVYNSEY
     YHFRQAWVPL RWMSPEAILE GDFSTKSDVW AFGVLMWEVF THGEMPHGGQ ADDEVLADLQ
     AGKARLPQPE GCPSKLFRLM QRCWALSPKD RPSFSEIAST LGDSPVDSKP
//
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