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Database: UniProt
Entry: F7G873_CALJA
LinkDB: F7G873_CALJA
Original site: F7G873_CALJA 
ID   F7G873_CALJA            Unreviewed;      2000 AA.
AC   F7G873;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 2.
DT   20-JUN-2018, entry version 47.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN5A {ECO:0000313|Ensembl:ENSCJAP00000018484};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000018484, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000018484, ECO:0000313|Proteomes:UP000008225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000018484}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   STRING; 9483.ENSCJAP00000018484; -.
DR   Ensembl; ENSCJAT00000019529; ENSCJAP00000018484; ENSCJAG00000009878.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; F7G873; -.
DR   OMA; TWDFCCG; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000008225; Unplaced.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR008053; Na_channel_a5su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01666; NACHANNEL5.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008225};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00085096};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084820};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084701};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
SQ   SEQUENCE   2000 AA;  225391 MW;  5E8BB376F759F384 CRC64;
     MANLLLPRGT SSFRRFTRES LAAIEKRMAE KQARSSAASQ ESREGLPEEE APRPQLDLQA
     SKKLPDLYGN PPRELIGEPL EDLDPFYSTQ KTFIVLNKGK TIFRFSATNA LYILSPFHPI
     RRAAVKILVH SYPFMLIMCT ILTNCVFMAQ HDPPPWTKYV EYTFTAIYTF ESLVKILARG
     FCLHAFTFLR DPWNWLDFSV IVMAYTTEFV DLGNVSALRT FRVLRALKTI SVISGLKTIV
     GALIQSVKKL ADVMVLTVFC LSVFALIGLQ LFMGNLRHKC VRNFTALNGT NGSVEADGSV
     WESLDLYLSD PGADSLYSWG RTCPEGYRCL KAGENPDHGY TSFDSFAWAF LALFRLMTQD
     CWERLYQQTL RSAGKIYMIF FMLVIFLGSF YLVNLILAVV AMAYEEQNQA TIAETEEKEK
     RFQEAMEMLK KEHEALTIRG VDTVSRSSLE MSPLAPVTIH ERRSKRRKRM SSGTEECGED
     RLPKSDSEDG PRAVNRLSLT HGLSRTSMKP RSSRGSIFTF RRRDLGSETD FADDENSTAG
     ESESHHTSLL VPWPLRRTGA QGQPSPGTAA PGHALNGKKN STVDCNGVVS LLGAGDPEAT
     SPGSHLLRPV MLEHPLDTTT PSEEPGGPRM LTPQAPCVDG FEEPEARQRA LSAVSVLTSA
     LEELEESQRK CPPCWNRFAQ RFLIWECCPL WISVKQGVKF VVTDPFADLT ITMCIVLNTL
     FMALEHYNMT SEFEDMLQVG NLVFTGIFTA EMTFKIIALD PYYYFQQGWN IFDSIIVVLS
     LMELGLSRMS NLSVLRSFRL LRVFKLAKSW PTLNTLIKII GNSVGALGNL TLVLAIIVFI
     FAVVGMQLFG KNYSELRHSD SGLLPRWHMM DFFHAFLIIF RILCGEWIET MWDCMEVSGQ
     SLCLLVFLLV MVIGNLVVLN LFLALLLSSF SADNLTAPDE DRELNNLQLA LARIQRGLRF
     IKWTTWDFCC GLLRQRPQKP AALAAPGQLP SCIATPHSPP PPETEKAPPA RKETRFEEGE
     QLGQGTPGDP ETVCVPIAVA ESDTDDQEED EENSLGPEEE SCKQQESQPV SDGPEAPPDS
     RTWSQVSATT SSEAEASASQ ADWQQQRKVE PRAPGCSETP EDSYSEGSTA DMTNTAELLE
     QIPDLGQDVK DPEDCFTEGC VRRCPCCAVD TTQAPGKVWW QLRKTCYRIV EHSWFETFII
     FMILLSSGAL AFEDIYLEER KTIKVLLEYA DKMFTYVFVL EMLLKWVAYG FKKYFTNAWC
     WLDFLIVDVS LVSLVANTLG FAEMGPIKSL RTLRALRPLR ALSRFEGMRV VVNALVGAIP
     SIMNVLLVCL IFWLIFSIMG VNLFAGKFGR CINQTEGDLP LNYTIVNNKS QCESLNMTGE
     LYWTKVKVNF DNVGAGYLAL LQVVSPGEKG TSFLPLAYEE QPQWEYNLYM YIYFVVFIIF
     GSFFTLNLFI GVIIDNFNQQ KKKIRGQDIF MTEEQKKYYN AMKKLGSKKP QKPIPRPLNK
     YQGFIFDVVT KQAFDVTIMF LICLNMVTMM VETDDQSPEK VNILTKINLL FVAIFTGECI
     FKMAALRHYY FTNSWNIFDF VVVILSIVGT VLSDIIQKYF FSPTLFRVIR LARIGRILRL
     IRGAKGIRTL LFALMMSLPA LFNIGLLLFL VMFIYSIFGM ANFAYVKWEA GIDDMFNFQT
     FANSMLCLFQ ITTSAGWDGL LSPILNTGPP YCDPNLPNSN GSRGDCGSPA VGILFFTTYI
     IISFLIVVNM YIAIILENFS VATEESTEPL SEDDFDMFYE TWEKFDPEAT QFIEYSALSD
     FADALSEPLR IAKPNQISLI NMDLPMVSGD RIHCMDILFA FTKRVLGESG EMDALKIQME
     EKFMAANPSK ISYEPITTTL RRKHEEVSAT VIQRAFRRHL LQRSMKHASF LFRQQAGSGL
     SEEDAPEREG LIAYMMNENF SRPPGLPSSS SISSTSFPPS YDSVTRATSD NLQVRGSDDS
     HSEDLADFPP SLDRDRESIV
//
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