ID F7G8D3_CALJA Unreviewed; 781 AA.
AC F7G8D3;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Cas scaffold protein family member 4 {ECO:0000313|Ensembl:ENSCJAP00000020795.4};
GN Name=CASS4 {ECO:0000313|Ensembl:ENSCJAP00000020795.4};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000020795.4, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000020795.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000020795.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC {ECO:0000256|ARBA:ARBA00004246}.
CC -!- SIMILARITY: Belongs to the CAS family. {ECO:0000256|ARBA:ARBA00007848}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; F7G8D3; -.
DR Ensembl; ENSCJAT00000021981.5; ENSCJAP00000020795.4; ENSCJAG00000011299.5.
DR GeneTree; ENSGT00950000183008; -.
DR Proteomes; UP000008225; Chromosome 5.
DR Bgee; ENSCJAG00000011299; Expressed in ovary and 3 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd11551; Serine_rich_CASS4; 1.
DR CDD; cd12000; SH3_CASS4; 1.
DR Gene3D; 1.20.120.230; Alpha-catenin/vinculin-like; 1.
DR Gene3D; 1.20.120.830; Serine-rich domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR021901; CAS_C.
DR InterPro; IPR037362; CAS_fam.
DR InterPro; IPR035744; CASS4_SH3.
DR InterPro; IPR014928; Serine_rich_dom.
DR InterPro; IPR038319; Serine_rich_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR10654; CAS SCAFFOLDING PROTEIN; 1.
DR PANTHER; PTHR10654:SF19; CAS SCAFFOLDING PROTEIN FAMILY MEMBER 4; 1.
DR Pfam; PF12026; CAS_C; 1.
DR Pfam; PF08824; Serine_rich; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 11..73
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 202..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 263..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 369..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 612..662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..246
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 638..661
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 781 AA; 86689 MW; 6F9B8B6F4E07646B CRC64;
MKGTGVVDAV PKALLARALY DNCPDCSDEL AFNRGDILTI LEQQVPESEG WWKCLLHGRQ
GLAPANRLQI LTEVAADRLR PPFLRGLEEA PASSEETYQV PTLPHPPTPG PVYEQMRSWV
EGPQPPTAQV YEFPDPPTSA RIICEKTLSF PKQAILTLPR PARASLPTLP SQVYDVPTQH
WGPGALKEPE KRQLYDIPAS PKKAGLHPPT GQASAQGVPQ LSPTTLRRGG YSTLPNPQKS
EWIYDTPGKT SIRNMSLTSF AEESGPHIVP SSSSTFHNPP SGRARSLTPQ LNNRVLMQKK
LSVPEIPSYG FLAPRDTFPL DTDVSYKVPS SFLMPRVEQQ NTKPNIYDIP KAMSSVFPAG
KELTKINEVS ENSTGHDSSW FSRRTTSLSP EPKRLSVSSS DSRASVVSSC STTSTDSSSS
SSSEESAKEL FLDLDVAKET VMALQHKVVS SVAGLMLFVS RKWRFRDYLE ANIDAIHRAT
DHIEESVREF LDFAQGVHGT ACNLTGSHLQ NRIRDQMQTI SNSYRILLET KESLDNRHWP
LEVLVTDNVQ NSPDDLERFV MVARMLPEDI KRFASIVIAN GRLLFKQNDE TVQLTPNAEF
KCKKCIQPPQ RETESYQNST LSTKQREDEH SSELLKKNRA NICGQNPGSL LPQTLSQQTP
EKKPHLSEHC RLYFGALFKA ISAFLSSLGS SQPPDILITQ SKLVIMVGQK LVDTLCKETQ
ERDVRNEILH SSSHLCSLLK DVALATKNAV LQYPSPAALG HLQAEAEKLE QHTRQFRGTL
G
//
