ID F7G9A2_ORNAN Unreviewed; 124 AA.
AC F7G9A2;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Glycoprotein hormones alpha chain {ECO:0000256|ARBA:ARBA00017839, ECO:0000256|RuleBase:RU362129};
GN Name=CGA {ECO:0000313|Ensembl:ENSOANP00000000878.2};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000000878.2, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000000878.2}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000000878.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Heterodimer. The active hormones thyrotropin, lutropin and
CC follitropin are heterodimers composed of CGA, a common alpha chain
CC described here and a unique beta chain which confers their biological
CC specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and
CC FSHB for follitropin. {ECO:0000256|RuleBase:RU362129}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU362129}.
CC -!- SIMILARITY: Belongs to the glycoprotein hormones subunit alpha family.
CC {ECO:0000256|ARBA:ARBA00009128, ECO:0000256|RuleBase:RU362129}.
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DR AlphaFoldDB; F7G9A2; -.
DR STRING; 9258.ENSOANP00000000878; -.
DR Ensembl; ENSOANT00000000879.2; ENSOANP00000000878.2; ENSOANG00000000551.2.
DR eggNOG; ENOG502S1PK; Eukaryota.
DR GeneTree; ENSGT00390000012242; -.
DR HOGENOM; CLU_148106_0_0_1; -.
DR InParanoid; F7G9A2; -.
DR OMA; MMQGCPE; -.
DR TreeFam; TF332733; -.
DR Proteomes; UP000002279; Unplaced.
DR Bgee; ENSOANG00000000551; Expressed in ovary and 1 other cell type or tissue.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016914; C:follicle-stimulating hormone complex; IBA:GO_Central.
DR GO; GO:0016913; F:follicle-stimulating hormone activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0010893; P:positive regulation of steroid biosynthetic process; IBA:GO_Central.
DR GO; GO:0006590; P:thyroid hormone generation; IBA:GO_Central.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR000476; Glyco_hormone.
DR PANTHER; PTHR11509; GLYCOPROTEIN HORMONE ALPHA CHAIN; 1.
DR PANTHER; PTHR11509:SF0; GLYCOPROTEIN HORMONES ALPHA CHAIN; 1.
DR Pfam; PF00236; Hormone_6; 1.
DR PRINTS; PR00274; GLYCOHORMONE.
DR SMART; SM00067; GHA; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00779; GLYCO_HORMONE_ALPHA_1; 1.
DR PROSITE; PS00780; GLYCO_HORMONE_ALPHA_2; 1.
DR PROSITE; PS50277; GLYCO_HORMONE_ALPHA_3; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|RuleBase:RU362129};
KW Hormone {ECO:0000256|ARBA:ARBA00022702, ECO:0000256|RuleBase:RU362129};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Secreted {ECO:0000256|RuleBase:RU362129};
KW Signal {ECO:0000256|RuleBase:RU362129}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|RuleBase:RU362129"
FT CHAIN 25..124
FT /note="Glycoprotein hormones alpha chain"
FT /evidence="ECO:0000256|RuleBase:RU362129"
FT /id="PRO_5028506407"
SQ SEQUENCE 124 AA; 13966 MW; DADA66AAFBAEE390 CRC64;
MDYYKKYAAV ILATLSVFLH ILHSLPDGDF VSTELMTGCP GCRLRENKFF SKIGFPIYQC
IGCCFSRAYP TPARSKKTML VPKNITSEAT CCVANHFKKI TVMADTKIEN HTECTCGTCY
YHKS
//
