ID F7GA99_MACMU Unreviewed; 894 AA.
AC F7GA99;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Sorting nexin 14 {ECO:0000313|Ensembl:ENSMMUP00000033364.3};
GN Name=SNX14 {ECO:0000313|Ensembl:ENSMMUP00000033364.3,
GN ECO:0000313|VGNC:VGNC:77708};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000033364.3, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000033364.3}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000033364.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR RefSeq; XP_014992357.1; XM_015136871.1.
DR RefSeq; XP_014992358.1; XM_015136872.1.
DR AlphaFoldDB; F7GA99; -.
DR SMR; F7GA99; -.
DR Ensembl; ENSMMUT00000040298.3; ENSMMUP00000033364.3; ENSMMUG00000005446.4.
DR GeneID; 696632; -.
DR CTD; 57231; -.
DR VEuPathDB; HostDB:ENSMMUG00000005446; -.
DR VGNC; VGNC:77708; SNX14.
DR GeneTree; ENSGT00950000182856; -.
DR HOGENOM; CLU_053939_0_0_1; -.
DR OMA; MYVYVIS; -.
DR OrthoDB; 2877434at2759; -.
DR Proteomes; UP000006718; Chromosome 4.
DR Bgee; ENSMMUG00000005446; Expressed in spermatocyte and 22 other cell types or tissues.
DR ExpressionAtlas; F7GA99; baseline.
DR GO; GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IEA:InterPro.
DR CDD; cd06877; PX_SNX14; 1.
DR CDD; cd08722; RGS_SNX14; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR003114; Phox_assoc.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR037436; SNX14_PX.
DR InterPro; IPR037892; SNX14_RGS.
DR InterPro; IPR013937; Sorting_nexin_C.
DR PANTHER; PTHR22775; SORTING NEXIN; 1.
DR PANTHER; PTHR22775:SF44; SORTING NEXIN-14; 1.
DR Pfam; PF08628; Nexin_C; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF02194; PXA; 1.
DR Pfam; PF00615; RGS; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00313; PXA; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS51207; PXA; 1.
DR PROSITE; PS50132; RGS; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000006718}.
FT DOMAIN 78..252
FT /note="PXA"
FT /evidence="ECO:0000259|PROSITE:PS51207"
FT DOMAIN 284..416
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 518..638
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
SQ SEQUENCE 894 AA; 104073 MW; FA295ECF9B3E4DD8 CRC64;
MIFWSFVAGV VTFYCSLGPD SLLPNIFFTI KYKPKQLGLQ ELFPQGHSCA VCGKVKCKRH
RPSLLLENYQ PWLDLKISSK VDASLSEVLE LVLENFVYPW YRDVTDDESF VDELRITLRF
FASVLIRRIH KVDIPSIITK KLLKAAMKHI EVIVKARQKV KNTEFLQQAA LEEYGPELHV
ALRSRRDELH YLRKLTELLF PYILPPKATD CRSLTLLIRE ILSGSVFLPS LDFLADPDTV
NHLLIIFIDD SPPEKATEPA SPLVPFLQKF AEPRNKKPSV LKLELKQIRE QQDLLFRFMN
FLKQEGAVHV LQFCLTVEEF NDRILRPELS NDEMLSLHEE LQKIYKTYCL DESIDKIRFD
PFIVEEIQRI AEGPYIDVVK LQTMRCLFEA YEHVLSLLEN VFTPMFCHSD EYFRQLLRGA
ESPTRNSKFN RGSLSLDDFR NTQKRGESFG ISRIGSKIKG VFKSTTMEGA MLPNYGVAEG
EDDFIEEGIV VMEDDSPVEA VSTPNTPRNL AAWKISIPYV DFFEDPSSER KEKKERIPVF
CIDVERNDRR AVGHEPEHWS VYRRYLEFYV LESKLTEFHG TFPDAQLPSK RIIGPKNYEF
LKSKREEFQE YLQKLLQHPE LSNSQLLADF LSPNGGETQF LDKILPDVNL GKIIKSVPGK
LMKEKGQHLE PFIMNFINSC ESPKPKPSRP ELTILSPTSE NNKKLFNDLF KNNANRAENT
ERKQNQNYFM EVMTVEGVYD YLMYVGRVVF QVPDWLHHLL MGTRILFKNT LEMYTDYYLQ
CKLEQLFQEH RLVSLITLLR DAIFCENTEP RSLQDKQKGA KQTFEEMMNY IPDLLVKCIG
EETKYESIRL LFDGLQQPVL NKQLTYVLLD IVIQELFPEL NKVQKEVTSV TSWM
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