ID F7GBD1_MACMU Unreviewed; 1357 AA.
AC F7GBD1;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 83.
DE SubName: Full=Zinc finger protein 541 {ECO:0000313|Ensembl:ENSMMUP00000019323.4};
GN Name=ZNF541 {ECO:0000313|Ensembl:ENSMMUP00000019323.4,
GN ECO:0000313|VGNC:VGNC:112077};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000019323.4, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000019323.4}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000019323.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR SMR; F7GBD1; -.
DR STRING; 9544.ENSMMUP00000019323; -.
DR PaxDb; 9544-ENSMMUP00000019323; -.
DR Ensembl; ENSMMUT00000020649.4; ENSMMUP00000019323.4; ENSMMUG00000014729.4.
DR VEuPathDB; HostDB:ENSMMUG00000014729; -.
DR VGNC; VGNC:112077; ZNF541.
DR eggNOG; KOG4167; Eukaryota.
DR GeneTree; ENSGT00940000160330; -.
DR HOGENOM; CLU_018806_0_0_1; -.
DR InParanoid; F7GBD1; -.
DR OMA; FAYDCPD; -.
DR OrthoDB; 2906194at2759; -.
DR TreeFam; TF106431; -.
DR Proteomes; UP000006718; Chromosome 19.
DR Bgee; ENSMMUG00000014729; Expressed in spermatid and 10 other cell types or tissues.
DR GO; GO:0000118; C:histone deacetylase complex; IBA:GO_Central.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR GO; GO:0007140; P:male meiotic nuclear division; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 3.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR000949; ELM2_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR16089; REST COREPRESSOR COREST PROTEIN-RELATED; 1.
DR PANTHER; PTHR16089:SF23; ZINC FINGER PROTEIN 541; 1.
DR Pfam; PF01448; ELM2; 1.
DR Pfam; PF00096; zf-C2H2; 1.
DR Pfam; PF13912; zf-C2H2_6; 2.
DR SMART; SM01189; ELM2; 1.
DR SMART; SM00717; SANT; 1.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS51156; ELM2; 1.
DR PROSITE; PS51293; SANT; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 140..167
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 168..195
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 838..865
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1062..1154
FT /note="ELM2"
FT /evidence="ECO:0000259|PROSITE:PS51156"
FT DOMAIN 1169..1220
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT DOMAIN 1300..1327
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 46..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 113..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 235..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 283..533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 569..673
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 686..754
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 932..979
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1233..1296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..320
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 400..416
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 932..949
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1233..1271
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1272..1294
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1357 AA; 146847 MW; EBD7138D0684EFD2 CRC64;
MDQYSLGDEG ALPSEMHLPS FSESQGLNCS DTLNRDLGPN TRDLLYAGLS GLDPDPNLPT
PDMSSEVLED NLDTLSLYSG KDSDSVKLLE EYADSESQAS LQDLGLGVLK AKEADEGGRA
TSGSARKGKR QHSSPQNPLL DCSLCGKVFS SASSLSKHYL THSQERKHVC KICSKAFKRQ
DHLTGHMLTH QKTKPFVCIE QGCSKSYCDY RSLRRHYEVQ HGLCILKEAP PEEEACGDSP
HAHESAGQPP SSSLRSLVPP EARSPGSLLP HRDLLRRIVS SIVHQKTPSP GPAPAGASDS
EGRNTACPCP ASSRSSSCTP AGPPAAPAAL DTELPEEPRL SQKESATDVF TAPHSRAAEN
GASDPPEPEP DPALLQARST AEGWPEGGSV PACLPLFRGQ TVPASSQPSS HSFQWLRNLP
GCPKSKGNNM FVVHKPPAVP SRESSESGPG PSSAAPSEES PPGPGGGLED ALPFPPALLK
ASGEALSDPR SASGEDDPCA PRKGKLDCDS FLCQNPGEPG LQEAQKSGGL PADASPLFRQ
LFLKSQEPLV SHEQMQVFQM ITKSQRIFSH AQVSKASSQL PAPEGKPAAL RPLQGPWPQQ
LPPLAPAVDS LNAGPGNPEA EGSPARRRKT TPGVAREASP GNTRRDAKGG LKVAAVPTPL
AAPSLDPSRN PDISSLAKQL RSSKGTLDLG DIFPSTGQRQ TQLGGEELPG ASLPGKQAPA
ENGAVSGTTK GEKGPPCSRG GGYRLLGNPR APRFSGFRKE KAKMDMCCAA SPSQVAMASF
SSAGPPADPS KSKLTIFSRI QGGNIYRLPH PVKEENVAGG GNQQNGGSTD WTEPRSTFIC
KNCSQMFYTE KGLSSHMCFH SDQWPSPRGK QEPQVFGTEF CKPLRQVLRP EGDRHSPPGA
KKPLDSTAAA PLVVPHSIPV VPVTRHVGSM AMEQEKDGEE RDSKESSQQR KRKKRPPPKR
LFIPPPPSTA GEPGPAGCHQ SRLRSPMFLV DRLLKGLFQC SPYTPPPMLS PIREGSGVYF
NTLCSTSTQA SPDQLISSML DQVDGSFGIC VVKDDTKISI EPHINIGSRF QAEIPELQER
SLAGIDEHVA SLVWKPWGDM MINPETQDRV TELCNVACSS VMPGGGTNLE LALHCLHEAQ
GNVQVALETL LLRGPHKPPT HLLADYRYTG SDVWTPIEKR LFKKAFYAHK KDFYLIHKTI
QTKTVAQCVE YYYIWKKMIK FDCGRAPGLE KRVKREPEEV ERTEEKVPCS PRERPSHHPI
PELKIKTKSY RRESILSSSP NAGPKRTPEP SGSVESQGIF PCRECERVFD KIKSRNAHMK
RHRLQDHVEP IVRVKWPVKP FQLKEEELGA DIGPLQW
//
