ID F7GC87_ORNAN Unreviewed; 426 AA.
AC F7GC87;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Eva-1 homolog C {ECO:0000313|Ensembl:ENSOANP00000002685.3};
GN Name=EVA1C {ECO:0000313|Ensembl:ENSOANP00000002685.3};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000002685.3, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000002685.3, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000002685.3,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000002685.3}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000002685.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the EVA1 family.
CC {ECO:0000256|ARBA:ARBA00006023}.
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DR AlphaFoldDB; F7GC87; -.
DR STRING; 9258.ENSOANP00000002685; -.
DR Ensembl; ENSOANT00000002686.3; ENSOANP00000002685.3; ENSOANG00000001678.3.
DR eggNOG; KOG4729; Eukaryota.
DR GeneTree; ENSGT00940000162103; -.
DR HOGENOM; CLU_050537_0_1_1; -.
DR InParanoid; F7GC87; -.
DR OMA; LWTRRMN; -.
DR TreeFam; TF328177; -.
DR Proteomes; UP000002279; Chromosome 17.
DR Bgee; ENSOANG00000001678; Expressed in adult mammalian kidney and 7 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0008201; F:heparin binding; IBA:GO_Central.
DR CDD; cd22828; Gal_Rha_Lectin_EVA1_EVA1C_rpt1; 1.
DR CDD; cd22829; Gal_Rha_Lectin_EVA1_EVA1C_rpt2; 1.
DR Gene3D; 2.60.120.740; -; 2.
DR InterPro; IPR039500; EVA1_dom.
DR InterPro; IPR000922; Lectin_gal-bd_dom.
DR InterPro; IPR043159; Lectin_gal-bd_sf.
DR PANTHER; PTHR46780; PROTEIN EVA-1; 1.
DR PANTHER; PTHR46780:SF4; PROTEIN EVA-1 HOMOLOG C; 1.
DR Pfam; PF14851; FAM176; 1.
DR Pfam; PF02140; Gal_Lectin; 2.
DR PROSITE; PS50228; SUEL_LECTIN; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..35
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 36..426
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5027768778"
FT DOMAIN 54..146
FT /note="SUEL-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50228"
FT DOMAIN 155..247
FT /note="SUEL-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50228"
FT REGION 345..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 426 AA; 46309 MW; 88E8F694F2427A30 CRC64;
MPRPRPPPPS RPPPAALLLR LFYCTFLVWP DEAAALADFS GYLSKLLQNH TALACDGDRL
SLQCPRHSSI SVQAAFYGPD SKRCGSRPPD VERADGPACA APTTLQKVLD ECQDRRACQL
PVNSRLFGPD PCPGVAKSLL VSFKCKPDEF KTKTACEDQE VKLHCHETKV LNIYSAAFGR
TAHETDVCPS AAGREPQFDC LSYSALEVLS QRCYGKQRCK IMVSDHQFGS PCLPGVKKYL
TVGYACVPKH ILSAIDPMVS LLNPTWKQKD GDYGTKLGPG GSRGLKTEGV IVSSSLAVFA
YVRAHPERAA LLFVSSVCLG LVVTLGAVVA RGSCPKDCRE LRPAQEPLML ESGGAREGSG
DEDDDSSGSD FPDEWPDFHR SPPPPRGAPE AADLAERLEW RDQIIQEIWL SSGLDASPPR
NLGQDY
//
