ID F7GDJ5_MONDO Unreviewed; 1009 AA.
AC F7GDJ5;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Elastin microfibril interfacer 2 {ECO:0000313|Ensembl:ENSMODP00000026821.3};
GN Name=EMILIN2 {ECO:0000313|Ensembl:ENSMODP00000026821.3};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000026821.3, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000026821.3, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000026821.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F7GDJ5; -.
DR STRING; 13616.ENSMODP00000026821; -.
DR Ensembl; ENSMODT00000027302.4; ENSMODP00000026821.3; ENSMODG00000021467.4.
DR eggNOG; ENOG502QV5P; Eukaryota.
DR GeneTree; ENSGT01030000234633; -.
DR HOGENOM; CLU_011705_0_0_1; -.
DR InParanoid; F7GDJ5; -.
DR OMA; PAWPGWT; -.
DR TreeFam; TF331033; -.
DR Proteomes; UP000002280; Chromosome 3.
DR Bgee; ENSMODG00000021467; Expressed in hindlimb bud and 18 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:Ensembl.
DR GO; GO:0030336; P:negative regulation of cell migration; IEA:Ensembl.
DR GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0030194; P:positive regulation of blood coagulation; IEA:Ensembl.
DR GO; GO:1900426; P:positive regulation of defense response to bacterium; IEA:Ensembl.
DR GO; GO:1901731; P:positive regulation of platelet aggregation; IEA:Ensembl.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR001073; C1q_dom.
DR InterPro; IPR011489; EMI_domain.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR15427; EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER; 1.
DR PANTHER; PTHR15427:SF5; EMILIN-2; 1.
DR Pfam; PF00386; C1q; 1.
DR Pfam; PF07546; EMI; 1.
DR SMART; SM00110; C1Q; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS50871; C1Q; 1.
DR PROSITE; PS51041; EMI; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 48..124
FT /note="EMI"
FT /evidence="ECO:0000259|PROSITE:PS51041"
FT DOMAIN 857..1008
FT /note="C1q"
FT /evidence="ECO:0000259|PROSITE:PS50871"
FT REGION 123..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 572..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 711..798
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 832..854
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 453..510
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 143..166
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 716..738
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 740..781
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1009 AA; 110738 MW; 7B17019990585958 CRC64;
QPARCPEQVS ASSPLTLSLA GASPLGGAGS LPACHSPSPQ SPRARSQPQN WCAYIVNKNV
SCSVLEGTES FIQAQYKCAW NQIPCPSTPV YRVNFRPRYT IKFKTVTQLE WRCCPGFKGG
DCQEGPKEPA KTLPTPARPR NTMKKATDTE PKPITEPKKT SEPKHPTEPR QTASPKPGLQ
EQQDKKIQVL EDKVSRLTRT VLDLQSSIAG VNENLKHAVQ DDASKMLASW LNSLHNPPGP
DSVVGGETET VQLPGLLGGK ESGMKDIKSE WKMRDLKTSC EYKLTGLQQQ CDDYGKKETS
LGKEINDLRA QIQTPSKQPD CCNHDKTVDF GQQIKDLDQK IERVAEATRM LNGRLDNEFD
HLTVPEPDES FDERWNELDA RINVTEKNAE EHCFYIEETL RGTINGEVDD LKQLLDQKIQ
SLEDRLGSSL LEIANGTDVK VINLESVLPG SGNGQVTTEL NHLKNKIQDV ENLCLQNLQG
SQVAEDTDSK KRSEQKMDDT SDLLKALNDT MYRKFREVEF NIQKVQVDLS LIFSHLNDTE
KDIKNLEGGL NNCQEQLAGA ISTCRKAEDS VSRRLDELER TTENPTPSQA PSGNCCRDLE
VRLQGLQKQV LSDLDICKES AQGVQREIVV VGGRVSHVEK ACSKLDSISG SLHRIKEGLN
KHVTNLWNCV SQMNGTIVAH SKDINSLKNS VQQITGHVFQ ITTDLQDLMK GQPAACNSPD
PSQPEVPKES SHPKTPQQLP DSKGPLPPQT PGKPFQPGIP QQPSQPKIPL QPSPPEKMPP
HSELPGWTGL PFLPGSTGVI METGEAGPPG KMVMSGRGLP NGVDGQDSRW PIPSSEGYAG
APGYPKPPSP VESQGIPTAS LVSFSAGLTQ KPFPSEAGVV LFNKVLVNDG DFYNPNTGIF
TAPYDGRYLI TAILTPERDE YVEAVLSVSN ASVAQLHTAG YRRELLEYHR PRGGLHTCGG
TGTFHLIVHL KAGDEVNIVV TGGRLAHTDF DEMYSTFSGV FLYPFLSHI
//