ID F7GE74_ORNAN Unreviewed; 340 AA.
AC F7GE74;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Amyloid beta precursor protein binding family B member 3 {ECO:0000313|Ensembl:ENSOANP00000026209.3};
GN Name=APBB3 {ECO:0000313|Ensembl:ENSOANP00000026209.3};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000026209.3, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000026209.3, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000026209.3,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000026209.3}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000026209.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; F7GE74; -.
DR STRING; 9258.ENSOANP00000026209; -.
DR Ensembl; ENSOANT00000030011.3; ENSOANP00000026209.3; ENSOANG00000020608.3.
DR eggNOG; ENOG502QR5N; Eukaryota.
DR GeneTree; ENSGT00390000000002; -.
DR HOGENOM; CLU_999430_0_0_1; -.
DR TreeFam; TF314331; -.
DR Proteomes; UP000002279; Chromosome X2.
DR Bgee; ENSOANG00000020608; Expressed in cerebellum and 7 other cell types or tissues.
DR GO; GO:0001540; F:amyloid-beta binding; IEA:InterPro.
DR CDD; cd01272; PTB1_Fe65; 1.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR039576; APBB1/2/3.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR14058; AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B; 1.
DR PANTHER; PTHR14058:SF10; AMYLOID-BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 3; 1.
DR Pfam; PF00640; PID; 1.
DR Pfam; PF00397; WW; 1.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00456; WW; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS01179; PID; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002279}.
FT DOMAIN 29..61
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 119..254
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT REGION 54..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 307..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 340 AA; 36594 MW; 0E647A840EC2049E CRC64;
MLGKDYMLAI ILVNCDDDLW GDQSLEGERG LPPGWRKIRD AAGTYYWHVP TGSTQWQRPT
LDPGEPALPS AGPTAAGGLR PPKGRSFSSL EGSPDRRSSL SWGRDELSVS SEEPGSKCFA
VRSLGWVEVP EEDLTPGKSS IVVNNCIQQL AQSRGRARPP TGAWAEDQNM VMILKKDTMS
LVNPLDRSLI HCQPLLHIRV WGVGCTNGRD RDFAFVASDK DTCMLKCHVF RCNVPAKAIA
TALHGLCAQI LAERAGANGD PASCSPDPIS PEDLPRQVEI LDAMSQAAQR YEALYVGSVP
VPKAMGGAGS GGGAAVAVPG EARDLHRSGP RPPHLRPHRR
//
