ID F7GEU2_MACMU Unreviewed; 622 AA.
AC F7GEU2;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Schlafen family member 12 like {ECO:0000313|Ensembl:ENSMMUP00000007334.4};
GN Name=SLFN12L {ECO:0000313|Ensembl:ENSMMUP00000007334.4};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000007334.4, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000007334.4}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000007334.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_014974566.1; XM_015119080.1.
DR AlphaFoldDB; F7GEU2; -.
DR SMR; F7GEU2; -.
DR Ensembl; ENSMMUT00000007807.4; ENSMMUP00000007334.4; ENSMMUG00000060439.1.
DR GeneID; 106992394; -.
DR CTD; 100506736; -.
DR VEuPathDB; HostDB:ENSMMUG00000060439; -.
DR eggNOG; ENOG502RU3F; Eukaryota.
DR GeneTree; ENSGT00410000025651; -.
DR HOGENOM; CLU_034558_0_0_1; -.
DR OrthoDB; 5398472at2759; -.
DR TreeFam; TF337168; -.
DR Proteomes; UP000006718; Chromosome 16.
DR Bgee; ENSMMUG00000060439; Expressed in spleen and 5 other cell types or tissues.
DR ExpressionAtlas; F7GEU2; baseline.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.30.950.30; Schlafen, AAA domain; 1.
DR InterPro; IPR031450; Poxin-SLFN/SLFN_N.
DR InterPro; IPR029684; Schlafen.
DR InterPro; IPR007421; Schlafen_AlbA_2_dom.
DR InterPro; IPR038461; Schlafen_AlbA_2_dom_sf.
DR InterPro; IPR048729; SLFN_GTPase-like.
DR PANTHER; PTHR12155; SCHLAFEN; 1.
DR PANTHER; PTHR12155:SF46; SCHLAFEN FAMILY MEMBER 12-LIKE; 1.
DR Pfam; PF17057; B3R; 1.
DR Pfam; PF04326; SLFN_AlbA_2; 1.
DR Pfam; PF21026; SLFN_GTPase-like; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 604..621
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 138..254
FT /note="Poxin-Schlafen/Schlafen-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF17057"
FT DOMAIN 256..370
FT /note="Schlafen AlbA-2"
FT /evidence="ECO:0000259|Pfam:PF04326"
FT DOMAIN 443..580
FT /note="Schlafen GTPase-like"
FT /evidence="ECO:0000259|Pfam:PF21026"
SQ SEQUENCE 622 AA; 70869 MW; AE22F4CCCF2EBEF2 CRC64;
MDCPIEMQLR EGLAAHQTPT AGKWIRTQVP LLGEECTEVD VSRKELLLGN CLTAGKMNIS
IDLDTNYAEL VLNVGRVTLG ENNRNKMKDR QLSKQQNENI SRAVCALLNS GGGVIKAEVE
NEDYSYKKDG IGLDLENSFS NMLPFVPNFL DFMQNGNYFH IFVKSWSLDT SSLQIATLSS
SLYKRDVTSA KVMNASAALE FLKDKEKTGG RAYLRPELPA KRACVDVQEE SNMEALAADF
FNRTELNYKE KLTFTESTHV EIKNFSTEKL LQRIREILPQ YVSAFANTDG GYLFVGLNKD
KEIIGFKSEK SYLTKLEEVT KNSIGKLPVH HFCMEKGTIN YLCKFLGVYD KGSLCGYVYA
LRVERFCCAV FAKKPDSWHV KDNRVKQLTE KEWIQFMVDS ERVYEELPSP ASTSSPVSQS
CPLREYINFK IQPRRYHLPG LSEKITCTPE TLCRNLFSQH EGLEQLICEE MGSVSKGSLI
FSRSWSLDLG LQENHKVLCD ALLISQDKPP VLYTFHTVQD EEFKGYSTQT ALTLKQKLAK
IGGYTEKVCV MTKIFYLSPE GKTSCQYDLN LQVIYPESYY RTTTRTVKDL EEALSNILPE
ENQIFLFVCL FILFLFVCFF LR
//
