ID F7GFU3_CALJA Unreviewed; 913 AA.
AC F7GFU3;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=phosphoinositide 5-phosphatase {ECO:0000256|ARBA:ARBA00013044};
DE EC=3.1.3.36 {ECO:0000256|ARBA:ARBA00013044};
GN Name=INPP5B {ECO:0000313|Ensembl:ENSCJAP00000003895.4};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000003895.4, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000003895.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000003895.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome membrane
CC {ECO:0000256|ARBA:ARBA00004580}. Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004146}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004608}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase
CC type II family. {ECO:0000256|ARBA:ARBA00005910}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; F7GFU3; -.
DR STRING; 9483.ENSCJAP00000003895; -.
DR Ensembl; ENSCJAT00000004107.5; ENSCJAP00000003895.4; ENSCJAG00000002125.5.
DR eggNOG; KOG0565; Eukaryota.
DR eggNOG; KOG4270; Eukaryota.
DR GeneTree; ENSGT00940000156762; -.
DR HOGENOM; CLU_006779_2_0_1; -.
DR InParanoid; F7GFU3; -.
DR OMA; VREDAWC; -.
DR TreeFam; TF317034; -.
DR Proteomes; UP000008225; Chromosome 7.
DR Bgee; ENSCJAG00000002125; Expressed in cerebellum and 6 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IEA:Ensembl.
DR GO; GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0030317; P:flagellated sperm motility; IEA:Ensembl.
DR GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
DR GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:Ensembl.
DR GO; GO:0070613; P:regulation of protein processing; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR CDD; cd09093; INPP5c_INPP5B; 1.
DR CDD; cd04380; RhoGAP_OCRL1; 1.
DR Gene3D; 2.30.29.110; -; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR031896; INPP5B_PH_dom.
DR InterPro; IPR046985; IP5.
DR InterPro; IPR000300; IPPc.
DR InterPro; IPR048869; OCRL-1_2_ASH.
DR InterPro; IPR037793; OCRL1/INPP5B_INPP5c.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR047078; RhoGAP_OCRL1.
DR PANTHER; PTHR11200; INOSITOL 5-PHOSPHATASE; 1.
DR PANTHER; PTHR11200:SF163; TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE; 1.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR Pfam; PF16776; INPP5B_PH; 1.
DR Pfam; PF21310; OCRL-like_ASH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00128; IPPc; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225}.
FT DOMAIN 741..913
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 182..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..222
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 913 AA; 104216 MW; 323C582712A4773E CRC64;
MDQSVAIQET LAEGEYCPQA VQGVLCEGDS RQSRLLGLVR YCLEHGGQEH ALFLYTHRRM
AITGDDVSLD QIVPVSRDFT LEEVPPDGEI YILGSDVTVQ LDTAELSLIF QLPFGSQTRM
FLHEVARACP GFDSATRDPE FLWLTRYRRP EPEPELPTPL DCNSAAGTWL GCATIGGGGS
NFDGLRPDGK GLPMDQNPSD QDKPESLQPR QNKSKSQITD MVRSSTITVS DKAHILSMQK
FGLRDTIVKS HLLQKEEDYT YIQNFRFFVG TYNVNGQSPK ECLRPWLSEG IEAPDVYCVG
FQELDLSKEA FFFHDTPKEE EWFKAVSEGL HPDAKYAKVK LIRLVGIMLL LYVKREHAAY
ISEVEAETVG TGIMGRMGNK GGVAIRFQFH NTSICVVNSH LAAHTEENAR RNQDYKDICS
RMQFYQLDPS LPPLTISKHD VILWLGDLNY RIENMDVEKV KKLIEEKDFQ TLYEYDQLKI
QVDKKTVFEG FTEGELTFQP TYKYDTGSDD WDTSEKCRAP AWCDRILWKG KNITQLSYQS
HMALKTSDHK PVHSLFDIGV RVINDELYRK TLEEIVRSLD KMENANIPSV SLSKREFCFQ
NVKYMQLQVE SFTIHNGQVP CHFEFINKPD EESYCKQWLN ANPSRGFLLP DSDIEIELEL
FVNKTTATKL NSGEDKIEDI LVLHLDRGKD YFLPVSGNYL PSCFGSPIHT LCYMREPILD
LPLETISKLT LMPIQTEGNG SQLERPLEIP KELWMMVDYL YRNAVQQEDL FQQPGLRSEF
EHIRDYLDTG MIDNLSASNH SVAEALLLFL ESLPEPVICY SAYHNCLECS GNYTASKQVI
STLPTFHNNV FKYLMAFLQE LLKNSAKNHL DENILASIFG SLLLRNPAGH QKLDMMEKKK
AQEFIHQFLC NPL
//
