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Database: UniProt
Entry: F7GGW1_CALJA
LinkDB: F7GGW1_CALJA
Original site: F7GGW1_CALJA 
ID   F7GGW1_CALJA            Unreviewed;      1529 AA.
AC   F7GGW1; U3BUE1;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   25-MAY-2022, sequence version 4.
DT   24-JAN-2024, entry version 66.
DE   RecName: Full=P-type Cu(+) transporter {ECO:0000256|ARBA:ARBA00012517};
DE            EC=7.2.2.8 {ECO:0000256|ARBA:ARBA00012517};
GN   Name=ATP7B {ECO:0000313|Ensembl:ENSCJAP00000015472.5};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000015472.5, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000015472.5}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000015472.5}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC       {ECO:0000256|ARBA:ARBA00004166}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004166}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC       family. Type IB subfamily. {ECO:0000256|RuleBase:RU362081}.
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DR   Ensembl; ENSCJAT00000016346.5; ENSCJAP00000015472.5; ENSCJAG00000008347.5.
DR   GeneTree; ENSGT00940000155749; -.
DR   OMA; NSWISGT; -.
DR   Proteomes; UP000008225; Chromosome 1.
DR   Bgee; ENSCJAG00000008347; Expressed in liver and 6 other cell types or tissues.
DR   GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
DR   GO; GO:0005770; C:late endosome; IEA:Ensembl.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR   GO; GO:0032588; C:trans-Golgi network membrane; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0005507; F:copper ion binding; IEA:Ensembl.
DR   GO; GO:0043682; F:P-type divalent copper transporter activity; IEA:Ensembl.
DR   GO; GO:0140581; F:P-type monovalent copper transporter activity; IEA:UniProtKB-EC.
DR   GO; GO:0015677; P:copper ion import; IEA:Ensembl.
DR   GO; GO:0046688; P:response to copper ion; IEA:Ensembl.
DR   GO; GO:0051208; P:sequestering of calcium ion; IEA:Ensembl.
DR   CDD; cd00371; HMA; 6.
DR   CDD; cd02094; P-type_ATPase_Cu-like; 1.
DR   Gene3D; 3.30.70.100; -; 6.
DR   Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR   Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR   Gene3D; 1.20.1110.10; Calcium-transporting ATPase, transmembrane domain; 1.
DR   Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR   InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR   InterPro; IPR018303; ATPase_P-typ_P_site.
DR   InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR   InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR017969; Heavy-metal-associated_CS.
DR   InterPro; IPR006122; HMA_Cu_ion-bd.
DR   InterPro; IPR006121; HMA_dom.
DR   InterPro; IPR036163; HMA_dom_sf.
DR   InterPro; IPR027256; P-typ_ATPase_IB.
DR   InterPro; IPR001757; P_typ_ATPase.
DR   InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR   NCBIfam; TIGR01525; ATPase-IB_hvy; 1.
DR   NCBIfam; TIGR01494; ATPase_P-type; 1.
DR   NCBIfam; TIGR00003; copper ion binding protein; 6.
DR   PANTHER; PTHR46594; P-TYPE CATION-TRANSPORTING ATPASE; 1.
DR   PANTHER; PTHR46594:SF4; P-TYPE CATION-TRANSPORTING ATPASE; 1.
DR   Pfam; PF00122; E1-E2_ATPase; 1.
DR   Pfam; PF00403; HMA; 6.
DR   Pfam; PF00702; Hydrolase; 1.
DR   PRINTS; PR00119; CATATPASE.
DR   PRINTS; PR00942; CUATPASEI.
DR   SFLD; SFLDS00003; Haloacid_Dehalogenase; 1.
DR   SFLD; SFLDF00027; p-type_atpase; 1.
DR   SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR   SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR   SUPFAM; SSF56784; HAD-like; 1.
DR   SUPFAM; SSF55008; HMA, heavy metal-associated domain; 6.
DR   SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR   PROSITE; PS00154; ATPASE_E1_E2; 1.
DR   PROSITE; PS01047; HMA_1; 6.
DR   PROSITE; PS50846; HMA_2; 6.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362081};
KW   Copper {ECO:0000256|ARBA:ARBA00023008};
KW   Copper transport {ECO:0000256|ARBA:ARBA00022796};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362081};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU362081};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU362081};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Translocase {ECO:0000256|ARBA:ARBA00022967};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362081};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362081}; Transport {ECO:0000256|ARBA:ARBA00023065}.
FT   TRANSMEM        669..688
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362081"
FT   TRANSMEM        708..730
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362081"
FT   TRANSMEM        742..768
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362081"
FT   TRANSMEM        774..795
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362081"
FT   TRANSMEM        938..962
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362081"
FT   TRANSMEM        982..1005
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362081"
FT   TRANSMEM        1389..1411
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362081"
FT   DOMAIN          73..139
FT                   /note="HMA"
FT                   /evidence="ECO:0000259|PROSITE:PS50846"
FT   DOMAIN          158..224
FT                   /note="HMA"
FT                   /evidence="ECO:0000259|PROSITE:PS50846"
FT   DOMAIN          272..338
FT                   /note="HMA"
FT                   /evidence="ECO:0000259|PROSITE:PS50846"
FT   DOMAIN          374..440
FT                   /note="HMA"
FT                   /evidence="ECO:0000259|PROSITE:PS50846"
FT   DOMAIN          503..569
FT                   /note="HMA"
FT                   /evidence="ECO:0000259|PROSITE:PS50846"
FT   DOMAIN          579..645
FT                   /note="HMA"
FT                   /evidence="ECO:0000259|PROSITE:PS50846"
FT   REGION          1496..1516
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1529 AA;  164326 MW;  009DFF9D1F87EFF2 CRC64;
     MTPSHGQNYE VPLKVNFLLF QPFPSRPSAQ PQMLSKLSLP TRAWEPAMKK SFAFDNVGYE
     GGLDGLGPSS QVTTSTIRIL GMTCQSCVKS IEDRISSLKG IVSVKVSVEQ GSATVNYVPS
     VLSPQQVCHQ IGDMGFEASI AEGKAASWPS RSLPAQEAVV KLRVEGMTCQ SCVSSIEGKV
     RKLQGVVRVK VSLSNQEAVI TYQPYLIQPE DLRDHVNDMG FEAAIKNKVA PLSLGPIDIE
     RLQSTYPKRL FTSANQNINN SETLGNQGNH VVTLQLRIDG MHCTSCILSI EENIGQLPGI
     QSIQVSLENK TAQVQYDPSC TSPVSLQRAI EALPPGNFKV SLPDGAEGCG TDHGPFSCHS
     PGFSQRNQVQ GTCSTTVIAI AGMTCASCVH SIEGMISQRE GVQQISVSLA EGTGTVLYNP
     SVISPEELSS AIEDMGFEAS VISENCSTNS LGNHSAGNSM VQTIGGVPVS VQEVAPHAGG
     LPTIHTPDIL AKSPQSTRAV APQKCFLQIK GMTCASCIST IERNLQNKAG ILSVLVALMA
     GKAEIKYDPE VVQPLEIAQL IQDLGFEAAV MEDYTGSDGS IELIITGMTC ASCVHNIESK
     LMRTNGITYA SVALATSKAL VKFDPEIIGP RDIIKIIEEI GFHASLAQRN PNAHHLDHKM
     EIKQWKKSFL CSLVFGIPVM ALMIYMLIPS SEPHESMVLD HNIIPGLSIL NLIFFILCTF
     VQLLGGWYFY VQAYKSLRHR SANMDVLIVL ATSIAYVYSL VILVVAVAEK AERSPVTFFD
     TPPMLFVFIA LGRWLEHLAK SKTSEALAKL MSLQAVEATV VTLGEDNLII REEQVPMELV
     QRGDIVKVVP GGKFPVDGKV LEGNTMADES LITGEAMPVT KKPGSTVIAG SINAHGAVLI
     KATHVGNDTT LAQIVKLVEE AQMSKAPIQQ LADRFSGYFV PFIIIMSTLT LVVWIVIGFI
     DFDVVQKYFP NPNKHISQTE VIIRFAFQTS ITVLCIACPC SLGLATPTAV MVGTGVAAQN
     GILIKGGKPL EMAHKIKTVM FDKTGTITHG VPRVMRVLLL GDMATLPLRK VLAVVGTAEA
     SSEHPLGVAV TKYCKELPEE AFTVSSGKPL RRHLCSRWRQ GLQSALATVP GYHKGMSVSL
     AFAQHHQELG TETLGYCTDF QAVPGCGIGC KVSNVEGILA HGGHPPSASH LNEAGSLSEG
     KDAAPQTFSV LIGNREWLRR NGLTISNDVS DAMTDHEMKG QTAILVAIDG VLCGMIAIAD
     AVKQEAALAV HTLQSMGVDV VLITGDNRKT ARAIATQVGI NKVFAEVLPS HKVAKVQELQ
     NKGKKVAMVG DGVNDSPALA QADMGVAIGT GTDVAIEAAD VVLIRNDLLD VVASIHLSKR
     TVRRIRINLV LALIYNLVGI PIAAGVFMPI GIVLQPWMGS AAMAASSVSV VLSSLQLKCY
     KKPELERYEA QVHGRIKPLT ASQVSVHIGM DDRRRDSPRA TPWDQVSYVS QVSLSSLTSD
     KPSRHSATVD DGGDKWSLLL NDRDEEQYI
//
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