ID F7GH93_MONDO Unreviewed; 564 AA.
AC F7GH93;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=F-box and leucine rich repeat protein 6 {ECO:0000313|Ensembl:ENSMODP00000013407.3};
GN Name=FBXL6 {ECO:0000313|Ensembl:ENSMODP00000013407.3};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000013407.3, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000013407.3, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000013407.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_001371748.1; XM_001371711.4.
DR RefSeq; XP_007488831.1; XM_007488769.2.
DR RefSeq; XP_007488832.1; XM_007488770.2.
DR RefSeq; XP_007488833.1; XM_007488771.2.
DR AlphaFoldDB; F7GH93; -.
DR Ensembl; ENSMODT00000013652.4; ENSMODP00000013407.3; ENSMODG00000010698.4.
DR GeneID; 100018579; -.
DR KEGG; mdo:100018579; -.
DR CTD; 26233; -.
DR eggNOG; KOG1947; Eukaryota.
DR GeneTree; ENSGT00390000009358; -.
DR HOGENOM; CLU_023545_1_1_1; -.
DR OrthoDB; 2908225at2759; -.
DR TreeFam; TF324422; -.
DR Proteomes; UP000002280; Chromosome 3.
DR Bgee; ENSMODG00000010698; Expressed in spermatid and 19 other cell types or tissues.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IEA:InterPro.
DR CDD; cd22119; F-box_FBXL6; 1.
DR Gene3D; 1.20.1280.50; -; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR047922; FBXL6_F-box.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR38926; F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED; 1.
DR PANTHER; PTHR38926:SF84; F-BOX_LRR-REPEAT PROTEIN 6; 1.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF13516; LRR_6; 2.
DR SMART; SM00367; LRR_CC; 3.
DR SUPFAM; SSF81383; F-box domain; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 142..190
FT /note="F-box"
FT /evidence="ECO:0000259|Pfam:PF12937"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 96..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..33
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..56
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..110
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 564 AA; 62818 MW; 8A33489152EB02B2 CRC64;
MEEVPEESSN GMALPPQEDS SSSQQSQVKS NKRLRPSVPV GPPQKRKKRK SSWRRPSARV
GYHIHEAEDM LLIVPNLEEP AARAHRKKAC HLRKLARPTT NVHQHRRTRR ERTRHDVDLS
LGQEKQSSPE DSTISGPGWG NHIPLEILVR IFQMIVASEG AVPFLCRAAR VCRLWYDATS
HSVLWQKVSL APPWPPHSKG PFSKVEKRIL SSLEWLVPNR FSLLRDLSLS HWKNHVPLML
KAVGVSCPHL TSLKLSHCQS VTTEALVSLL RTCPKLDSLN LQNSQVESTA VVSFLEAAGA
QLQQLWLTYS SQMTAIVSLL SNGCCPQLQL LEVDTGIKPN NQHFQLHIEA LQAGCPKLQV
LRLLNLVWSP KTGGRGVALG PGFPDLEELC LATSTITYVS DEVLYRLLHK SAHLRVLDLR
GCARLTPAGL GRLPCPIVEQ LHLGLYGSVI WVALPKEGSS LITWKWRRTL QELDLNGQCY
HEGDLKQALA AFSSTDSGHS PILRSLSLKG TQVTVATISS VISSCPALSY LNLSSCRYLP
RGLKRAYRGQ AEIQWCLDQL LTIF
//
