ID F7GIU0_MACMU Unreviewed; 421 AA.
AC F7GIU0; G7MU57;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE RecName: Full=5-hydroxytryptamine receptor 1A {ECO:0000256|ARBA:ARBA00017605};
DE AltName: Full=Serotonin receptor 1A {ECO:0000256|ARBA:ARBA00032310};
GN Name=HTR1A {ECO:0000313|EMBL:AGN73490.1,
GN ECO:0000313|Ensembl:ENSMMUP00000002380.1,
GN ECO:0000313|VGNC:VGNC:73536};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000002380.1, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|EMBL:AGN73490.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Mmul01 {ECO:0000313|EMBL:AGN73490.1}, Mmul02
RC {ECO:0000313|EMBL:AGN73491.1}, Mmul03 {ECO:0000313|EMBL:AGN73492.1},
RC Mmul05 {ECO:0000313|EMBL:AGN73493.1}, Mmul06
RC {ECO:0000313|EMBL:AGN73494.1}, Mmul07 {ECO:0000313|EMBL:AGN73495.1},
RC Mmul09 {ECO:0000313|EMBL:AGN73496.1}, Mmul13
RC {ECO:0000313|EMBL:AGN73497.1}, Mmul14 {ECO:0000313|EMBL:AGN73498.1},
RC Mmul15 {ECO:0000313|EMBL:AGN73499.1}, Mmul16
RC {ECO:0000313|EMBL:AGN73500.1}, Mmul18 {ECO:0000313|EMBL:AGN73501.1},
RC Mmul19 {ECO:0000313|EMBL:AGN73502.1}, Mmul20
RC {ECO:0000313|EMBL:AGN73503.1}, Mmul22 {ECO:0000313|EMBL:AGN73504.1},
RC Mmul23 {ECO:0000313|EMBL:AGN73505.1}, Mmul24
RC {ECO:0000313|EMBL:AGN73506.1}, Mmul25 {ECO:0000313|EMBL:AGN73507.1},
RC Mmul26 {ECO:0000313|EMBL:AGN73508.1}, and Mmul27
RC {ECO:0000313|EMBL:AGN73509.1};
RA Shattuck M.R., Satkoski-Trask J., Deinard A., Tito R.Y., Smith D.G.,
RA Melnick D.J., Malhi R.S.;
RT "Natural selection on genes underlying the serotonin system in Macaca.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSMMUP00000002380.1}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000002380.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: G-protein coupled receptor for 5-hydroxytryptamine
CC (serotonin). Also functions as a receptor for various drugs and
CC psychoactive substances. Ligand binding causes a conformation change
CC that triggers signaling via guanine nucleotide-binding proteins (G
CC proteins) and modulates the activity of down-stream effectors, such as
CC adenylate cyclase. Beta-arrestin family members inhibit signaling via G
CC proteins and mediate activation of alternative signaling pathways.
CC Signaling inhibits adenylate cyclase activity and activates a
CC phosphatidylinositol-calcium second messenger system that regulates the
CC release of Ca(2+) ions from intracellular stores. Plays a role in the
CC regulation of 5-hydroxytryptamine release and in the regulation of
CC dopamine and 5-hydroxytryptamine metabolism. Plays a role in the
CC regulation of dopamine and 5-hydroxytryptamine levels in the brain, and
CC thereby affects neural activity, mood and behavior. Plays a role in the
CC response to anxiogenic stimuli. {ECO:0000256|ARBA:ARBA00024768}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Cell
CC projection, dendrite {ECO:0000256|ARBA:ARBA00004279}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR EMBL; KC862395; AGN73490.1; -; Genomic_DNA.
DR EMBL; KC862396; AGN73491.1; -; Genomic_DNA.
DR EMBL; KC862397; AGN73492.1; -; Genomic_DNA.
DR EMBL; KC862398; AGN73493.1; -; Genomic_DNA.
DR EMBL; KC862399; AGN73494.1; -; Genomic_DNA.
DR EMBL; KC862400; AGN73495.1; -; Genomic_DNA.
DR EMBL; KC862401; AGN73496.1; -; Genomic_DNA.
DR EMBL; KC862402; AGN73497.1; -; Genomic_DNA.
DR EMBL; KC862403; AGN73498.1; -; Genomic_DNA.
DR EMBL; KC862404; AGN73499.1; -; Genomic_DNA.
DR EMBL; KC862405; AGN73500.1; -; Genomic_DNA.
DR EMBL; KC862406; AGN73501.1; -; Genomic_DNA.
DR EMBL; KC862407; AGN73502.1; -; Genomic_DNA.
DR EMBL; KC862408; AGN73503.1; -; Genomic_DNA.
DR EMBL; KC862409; AGN73504.1; -; Genomic_DNA.
DR EMBL; KC862410; AGN73505.1; -; Genomic_DNA.
DR EMBL; KC862411; AGN73506.1; -; Genomic_DNA.
DR EMBL; KC862412; AGN73507.1; -; Genomic_DNA.
DR EMBL; KC862413; AGN73508.1; -; Genomic_DNA.
DR EMBL; KC862414; AGN73509.1; -; Genomic_DNA.
DR RefSeq; NP_001185629.1; NM_001198700.1.
DR STRING; 9544.ENSMMUP00000002380; -.
DR PaxDb; 9544-ENSMMUP00000002380; -.
DR Ensembl; ENSMMUT00000002517.3; ENSMMUP00000002380.1; ENSMMUG00000001789.3.
DR GeneID; 694991; -.
DR KEGG; mcc:694991; -.
DR CTD; 3350; -.
DR VEuPathDB; HostDB:ENSMMUG00000001789; -.
DR VGNC; VGNC:73536; HTR1A.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000154484; -.
DR HOGENOM; CLU_009579_11_1_1; -.
DR OMA; CAESCYM; -.
DR OrthoDB; 2999405at2759; -.
DR TreeFam; TF316350; -.
DR Proteomes; UP000006718; Chromosome 6.
DR Bgee; ENSMMUG00000001789; Expressed in prefrontal cortex and 3 other cell types or tissues.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0004993; F:G protein-coupled serotonin receptor activity; IBA:GO_Central.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:0090722; F:receptor-receptor interaction; IEA:Ensembl.
DR GO; GO:0051378; F:serotonin binding; IBA:GO_Central.
DR GO; GO:0007198; P:adenylate cyclase-inhibiting serotonin receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0001662; P:behavioral fear response; IEA:Ensembl.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0035640; P:exploration behavior; IEA:Ensembl.
DR GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; IBA:GO_Central.
DR GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; IEA:Ensembl.
DR GO; GO:0050795; P:regulation of behavior; IEA:InterPro.
DR GO; GO:0042053; P:regulation of dopamine metabolic process; IEA:Ensembl.
DR GO; GO:0046883; P:regulation of hormone secretion; IEA:InterPro.
DR GO; GO:0014062; P:regulation of serotonin secretion; IEA:Ensembl.
DR GO; GO:0019229; P:regulation of vasoconstriction; IEA:InterPro.
DR GO; GO:0042428; P:serotonin metabolic process; IEA:Ensembl.
DR GO; GO:0007210; P:serotonin receptor signaling pathway; IEA:Ensembl.
DR CDD; cd15330; 7tmA_5-HT1A_vertebrates; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000610; 5HT1A_rcpt.
DR InterPro; IPR002231; 5HT_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24248; ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR24248:SF191; G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00512; 5HT1ARECEPTR.
DR PRINTS; PR01101; 5HTRECEPTOR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|RuleBase:RU000688, ECO:0000313|EMBL:AGN73490.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 40..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 69..98
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 110..131
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 152..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 194..217
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 346..367
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 379..402
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 52..399
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 234..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 241..255
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 421 AA; 45990 MW; B66F6537793DEE16 CRC64;
MDVLSPGQGN NTTSPPGPFE TSGNTTGISD VTSYQVITSL LLGTLIFCAV LGNACVVAAI
ALERSLQNVA NYLIGSLAVT DLMVSVLVLP MAALYQVLNK WTLGQVTCDL FIALDVLCCT
SSILHLCAIA LDRYWAITDP IDYVNKRTPR RAAALISLTW LIGFLISIPP MLGWRTPEDR
SDPDACTISK DHGYTIYSTF GAFYIPLLLM LVLYGRIFRA ARFRIRKTVK KVEKTGADTR
HGASPTPQPK KSVNGESGGR NWRLGVESKA GGALCANGAV RQGDDGAALE VIEVHRVGNS
KEHLPLPSEA GSTPCASASF ERKNERNADA KRKMALARER KTVKTLGIIM GTFILCWLPF
FIVALVLPFC ESSCHMPTLL GAIINWLGYS NSLLNPVIYA YFNKDFQNAF KKIIKCKFCR
Q
//
