ID F7GL19_MACMU Unreviewed; 2322 AA.
AC F7GL19;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Chondroitin sulfate proteoglycan 4 {ECO:0000313|Ensembl:ENSMMUP00000021185.4};
GN Name=CSPG4 {ECO:0000313|Ensembl:ENSMMUP00000021185.4,
GN ECO:0000313|VGNC:VGNC:71525};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000021185.4, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000021185.4}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000021185.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}.
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DR SMR; F7GL19; -.
DR STRING; 9544.ENSMMUP00000021185; -.
DR PaxDb; 9544-ENSMMUP00000021185; -.
DR Ensembl; ENSMMUT00000022647.4; ENSMMUP00000021185.4; ENSMMUG00000016104.4.
DR VEuPathDB; HostDB:ENSMMUG00000016104; -.
DR VGNC; VGNC:71525; CSPG4.
DR eggNOG; KOG3597; Eukaryota.
DR GeneTree; ENSGT00940000154091; -.
DR HOGENOM; CLU_000473_1_0_1; -.
DR InParanoid; F7GL19; -.
DR OMA; PWPQGTT; -.
DR OrthoDB; 4072625at2759; -.
DR TreeFam; TF316876; -.
DR Proteomes; UP000006718; Chromosome 7.
DR Bgee; ENSMMUG00000016104; Expressed in fibroblast and 19 other cell types or tissues.
DR ExpressionAtlas; F7GL19; baseline.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0001726; C:ruffle; IEA:Ensembl.
DR GO; GO:0015026; F:coreceptor activity; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0008347; P:glial cell migration; IEA:Ensembl.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:Ensembl.
DR GO; GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:Ensembl.
DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl.
DR GO; GO:0097178; P:ruffle assembly; IEA:Ensembl.
DR GO; GO:0006929; P:substrate-dependent cell migration; IEA:Ensembl.
DR CDD; cd00110; LamG; 2.
DR Gene3D; 2.60.120.200; -; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR039005; CSPG_rpt.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR45739:SF11; C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45739; MATRIX PROTEIN, PUTATIVE-RELATED; 1.
DR Pfam; PF16184; Cadherin_3; 12.
DR Pfam; PF02210; Laminin_G_2; 2.
DR SMART; SM00282; LamG; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR PROSITE; PS51854; CSPG; 15.
DR PROSITE; PS50025; LAM_G_DOMAIN; 2.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..2322
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023895396"
FT TRANSMEM 2225..2246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 29..192
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 202..380
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REPEAT 428..523
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 553..645
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 662..764
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 783..878
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 898..989
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1018..1110
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1126..1216
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1238..1337
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1356..1449
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1473..1563
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1581..1679
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1704..1803
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1832..1924
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1941..2029
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 2038..2147
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REGION 2182..2204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2322 AA; 250664 MW; 829A53040C4194E6 CRC64;
MQSGPRPPPP GPALALALTL AMLARLASTA SFFGENHLEV PVATALTDID LQLQFSTSQP
EALLLLAAGP ADHLLLQLYS GRLQVRLVLG QEELRLQTPA ETLLSDSVPH TTVLTVVEGW
ATLSVDGFLN ASSAVPGAPL EVPYGLFVGG TGSLGLPYLR GTSRPLRGCL HAATLNGRSL
LRPLTPDVHE GCAEEFSAGD DVALGFSGPH SLAAFPAWGT QDEGTLEFTL TTQSRQAPLA
FQAGGRRGDF IYVDIFEGHL RAVVEKGQGT VLLHNSVPVA DGQPHEVSVH INAHQLEVSV
DQYPTRTSNR GALSYLEPRG SLLLGGLDAE ASRHLQEHRL GLTPEATNAS LLGCMEDLSV
NGQRRGLREA LLTRNMVAGC RLEEEEYEDD AYGHYEAFST LAPEAWPAME LPEPCVPEPG
LPPVFANFTQ LLTISPLVVA EGGTAWLEWR HLQPTLDLME AELRKSQVLF SVTQGARHGE
LELDIPGAQA RKMFTLLDVV NRKARFIHDG SEDTSDQLVL EVSVTARVPM PSCLRRGQTY
LLPIQVNPVN DPPRIIFPHG SLMVILEHTQ KPLGPEVFQA YDPDSACEGL TFQFLGTPSG
LPVQRRDQPG EPATEFSCRE LEAGSLVYVH HGGPAQDLTF RVSDGLQASP PATLKVVAVR
PAIQIHRSTG LRLAQGSAMP ILPANLSVET NAVGQDVSVL FRVTRALQFG ELQKQGAGGV
EGAEWWATQA FHQRDVEQGR VRYLSTDPQH RTEDTVENLA LEVQVGQEIL SNLSFPVTIQ
RATVWMLRLE PLHTQNTQQE TLTTAHLEAS LEEAGPSPPA FHYEVVQAPR KGNLQLQGTR
LSDGQGFTQD DIQAGRVTYG ATARASEAVE DTFRFRVTAP PYFSPLYTFP IHIGGDPDAP
VLTNVLLMVP EGGEGVLSAD HLFVKSLNSA SYLYEVMERP RHGRLAWRGT QDKTTMVTSF
TNEDLLRGRL VYQHDDSETT EDDIPFVATR QGESSGDMAW EEVRGVFRVA IQPVNDHAPV
QTISRVFHVA RGGRRLLTTD DVAFSDADSG FADAQLVLTR KDLLFGSIVA VDEPTRPIYR
FTQEDLRKRR VLFVHSGADR GWIQLQVSDG QHQATALLEV QASEPYLRVA NGSRLVVPQG
GQGTIDTAVF HLDTNLDIRS GDEVHYHVTA GPRWGQVLRA GQPATAFSQQ DLLDGAVLYS
HNGSLSPRDT LAFSVEAGPV HTDATLQVTV ALEGPLAPLK LVRHKKIYVF QGEAAEIRRD
QLEAAQEAVP PADIVFSVKK PPSAGYLVMV SRGVLADEPP SLDPVQSFSQ EAVDTGRVLY
LHSRPEAWSD AFSLDVASGL GAPLEGVRME LEVLPAAIPL DAQNFSVPEG GSLTLAPPLL
RVTGPYFPTL PGLGLQVLEP PRHGALQKED EPQARTLSAF SWREVEEQLI RYVHDGSETL
TDSFVLMANA SEMDRQSHPV AFTVTVLPVN DQPPVLTTNT GLQMWEGATA PIPAEVLRST
DGDSGSEDLV YTIEQPSNGR VVLRAAPGTE VRSFTQAQLD GGLVLFSHRG TLDGGFRFGL
SDGEHTSSGH FFRVTAQKQV LLSLEGSRTL TVCPGSVQPL SSQTLRASSS AGTDPQLLLY
RVVRGPQLGR LFHAQQDSTG EALVNFTQAE VYAGNILYEH EMPTEPFWEA HDTLELQLSS
PPARDVAATL AVAVSFEAAC PQRPSHLWKN KGLWVPEGQR AKITMAALDA SNLLASVPSS
QRVEHDVLFQ VTQFPSRGQL LVSEEPLHAG QPHFLQSQLA AGQLVYAHGG GGTQQDGFHF
RAHLQGPAGA TVAGPQTSEA FAITVRDVNE RPPQPQASVP LRITRGSRAP ISRAQLSVVD
PDSAPGEIEY EVQRAPHNGF LSLVGGGPGP VTHFTQADVD SGRLAFVANG SSVAGVFQLS
MSDGASPPLP MSLAVDILPS AIEVQLQAPL EVPQALGRSS LSQQQLRVVS DREEPEAAYR
LIQGPKYGHL LVGGRPASAF SQLQIDQGEV VFAFTNFSSS HDHFRVLALA RGVNASAVVN
ITVRALLHVW AGGPWPQGAT LRLDPTILDA GELANRTGSV PHFRLLEGPR HGRVVRVPRA
RTEPGGSQLV EQFTQQDLED GRLGLEVGRP EGRAPSPTGD SLTLELWAQG VPPAVASLDF
ATEPYNAARP YSVALLSVPE ATRTEAGKPE SSTPTGEPGP MASSPVPAVA KGGFLGFLEA
NMFSVIIPVC LVLLLLALIL PLLFYLRKRN KTGKHDVQVL TAKPRNGLAG DTETFRKVEP
GQAIPLTAVP GQGPPPGGQP DPELLQFCRT PNPALKNGQY WV
//
