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Database: UniProt
Entry: F7GLF3_CALJA
LinkDB: F7GLF3_CALJA
Original site: F7GLF3_CALJA 
ID   F7GLF3_CALJA            Unreviewed;      1685 AA.
AC   F7GLF3;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 2.
DT   20-JUN-2018, entry version 45.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN7A {ECO:0000313|Ensembl:ENSCJAP00000011922};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000011922, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000011922, ECO:0000313|Proteomes:UP000008225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000011922}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   STRING; 9483.ENSCJAP00000011922; -.
DR   Ensembl; ENSCJAT00000012574; ENSCJAP00000011922; ENSCJAG00000006448.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410Y1Z2; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; F7GLF3; -.
DR   OMA; GMYNFAY; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000008225; Unplaced.
DR   GO; GO:0097386; C:glial cell projection; IEA:Ensembl.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0006936; P:muscle contraction; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   GO; GO:0055078; P:sodium ion homeostasis; IEA:Ensembl.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028812; Na_channel_a7su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10037:SF14; PTHR10037:SF14; 3.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008225};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00085096};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084820};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084701};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
SQ   SEQUENCE   1685 AA;  193702 MW;  3BC196C7C1381017 CRC64;
     MLASLEPKGL VPFTRESFER IQQRIAKTHN EEHEEEDLKP NTDLEVGKEL PFTYGNLSRG
     MVSEPLEDVD PYYHEKKNTF IVLNKNRTIF RFNAASILCT LSPFNCIRGT TIKVLVHPYP
     FLLASTLFRL FILISVLTDC IFMSLTNLPK WRPVVENTLL GIYTFEILVK LFARGVWAGS
     FSFLGDPWNW LDFSVTVFEI IIRYSPLSFI PMLQTVRTLR ILKIICLNQG LKSLVGVLIC
     CVKKLTGVII LTLFFLSIFS LIGMGLFMGN LKHKCFRWPQ ENENETLHNR TGNPYYIRET
     ENFYYLEGER YALLCGNRTD AGQCPEGYVC VKAGINPDQG FTNFDSFGWA LLALFRLMTQ
     DYPEALYHQI LYASGKVYMI FFVVVSFWFS FYMASLFLGI LAMAHEEEKQ RVGETTKKTE
     PKFQKTGKEL QGGNETAEAK AIQIEMKKRS PASTDTSLDV LEDATLRHKE ELEKSKKICP
     LCWYKFAETF LIWNCSPCWL KLKEFVHRII TAPFTDLFLF ICIILNVSFL ALEHYPMSEQ
     TSNLLSTGNL VFIGIFTAEM ILKIIAMHPY GYFQVGWNIF DSIIVFLGLA ELFLAYIEGL
     AVFQSFRMLR IFKLGKYWPT FQILMWSLSN SWVALKDLVL LLFTFIFFSA AFGMRLFGQN
     YEKFVCHIDR DCQLPRWHMH DFFHSFLNVF RIICGEWIET LWDCMQVAGQ SWCISFYLMV
     ILIGNLLVLY LFLALVSLFS SCKDVTAEEN DEAKNLRLAM AKIKKEINYA FLKILCKKQN
     IPEETMDRVN EVYVKEDISD HTLSELSNTQ DFLKDKEKSS GTEKNMTENE SQSLIPSPSV
     SETVPIASGE SDIENLDNKE IQSKSGDGGS KEKIKQSSSS ECSTVDIAIS EEEEMVYGHE
     SSKHPKNGYG HSSSLGQISG ASKKGKICRN IRKTCCKIVE NNWFKCFIGL VTLLSTSTLA
     LEDIYIDQRK TVKILLEYAD MIFTYIFILE MLLKWMAYGF KAYFSNSWYR LDFMVVIVFC
     LSLIGKTREE LQPLISIKFL RPLRVLSQFE RMKVVVRALI KTTLPTLNVF LVCLMIWLTF
     SIMGIHLFAG TFYECIDPTS GERFPSSEVM NKGQCESLLF NDSMPWENAK LNFDNVGNGF
     LSLLQLATFN GWITIMNSAI DSVAINMQPR FEDNIYMYYY FINFIILGVF LPLSMLISAI
     VDNFNKHKIK ISSNIFITVK HRKQYSRLKK LMYEDSQRPI PHPRSKLQGF IFDLVTSQVF
     NVIVMVLICF QAIAMMIDTD EHSLQMEIAL YWINLIFVIL YTMECILKLI AFRCFYFTIA
     WNIFDFMVVI FSITGLCLPM TVGYYLVPPS LVKLILLSRI IHILRLGKGP KVFHNLMLPL
     MLSLPALLNL ILLIFLVMFI YAIFGMYNFA YVKKEAGIND VSNFETFGSS MLCLFQVAIF
     AGWDGMLVAI FNSKWSDCDP DKINPGTQVR GDCGNPSVGI LYFVSYILIS WVIIVNMYIV
     VVMEFLTIAS KKKNRTLSED DFRKFFQVWK RFDPDRTQYI DSSKLSDFAA ALDPPLFMAK
     PNKGQLIALD LPMAVGDRIH CLDILLAFTK RVMGQDVRME KVLSEIESGF LLANPFKITC
     EPITTTLKRK QEAVSATIIQ RAYKNYRLRQ KDKNTSDIHM IDGDRDVPAT KEGAYFNKAN
     EKSPI
//
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