ID F7GUT7_CALJA Unreviewed; 2929 AA.
AC F7GUT7;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 92.
DE SubName: Full=Fibrillin 1 {ECO:0000313|Ensembl:ENSCJAP00000003235.3};
GN Name=FBN1 {ECO:0000313|Ensembl:ENSCJAP00000003235.3};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000003235.3, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000003235.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000003235.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the fibrillin family.
CC {ECO:0000256|ARBA:ARBA00008972}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR Ensembl; ENSCJAT00000003414.4; ENSCJAP00000003235.3; ENSCJAG00000001735.5.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00950000183158; -.
DR HOGENOM; CLU_000233_0_0_1; -.
DR TreeFam; TF316849; -.
DR Proteomes; UP000008225; Chromosome 10.
DR Bgee; ENSCJAG00000001735; Expressed in ovary and 6 other cell types or tissues.
DR GO; GO:0001527; C:microfibril; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 29.
DR Gene3D; 2.10.25.10; Laminin; 46.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 9.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR049388; FBN_EGF_N.
DR InterPro; IPR040872; Fibrillin_U_N.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR PANTHER; PTHR24039; FIBRILLIN-RELATED; 1.
DR PANTHER; PTHR24039:SF28; FIBULIN-1; 1.
DR Pfam; PF12662; cEGF; 5.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 32.
DR Pfam; PF21364; FBN_EGF_st1; 1.
DR Pfam; PF18193; Fibrillin_U_N; 1.
DR Pfam; PF14670; FXa_inhibition; 1.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF00683; TB; 9.
DR PIRSF; PIRSF036312; Fibrillin; 1.
DR SMART; SM00181; EGF; 47.
DR SMART; SM00179; EGF_CA; 44.
DR SUPFAM; SSF57196; EGF/Laminin; 13.
DR SUPFAM; SSF57184; Growth factor receptor domain; 10.
DR SUPFAM; SSF57581; TB module/8-cys domain; 9.
DR PROSITE; PS00010; ASX_HYDROXYL; 42.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 29.
DR PROSITE; PS50026; EGF_3; 39.
DR PROSITE; PS01187; EGF_CA; 15.
DR PROSITE; PS51364; TB; 9.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..2929
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023880091"
FT DOMAIN 292..324
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 330..373
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 392..433
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 434..475
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 480..535
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 636..671
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 676..717
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 718..758
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 759..799
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 805..857
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 869..910
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 911..952
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 953..992
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 997..1037
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1057..1098
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1103..1155
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1175..1216
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1217..1259
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1260..1301
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1302..1343
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1385..1426
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1427..1464
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1469..1509
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1510..1548
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1551..1592
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1593..1629
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1634..1674
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1679..1736
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1753..1794
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1795..1831
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1840..1895
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1913..1954
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1955..1995
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1996..2037
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2038..2073
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2077..2119
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2120..2159
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2160..2201
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2206..2258
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 2274..2312
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2313..2352
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2438..2479
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2484..2537
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 2549..2586
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2632..2668
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2671..2713
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2714..2753
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2754..2790
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 51..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2905..2929
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 296..306
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 314..323
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 640..650
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 957..967
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2042..2052
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2718..2728
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2929 AA; 316901 MW; D01867940BA660CC CRC64;
MKEGGVIFFF FLFFKQVFLS RETAAQTILE EVGKGGGRGS RGRDCGCHKR TGGHSWDSCG
RSGDCSGQDR EQSPPPPRES EPPLLHWQGP PEVGAAPGEG GRSPARGTGG RRAGPRRRGA
LQGAAAAADQ ALGAAGGGGC RRRLGIMWRG GLLEIVLGFT VLLASYTSHG ADANLEAGNV
KESRASRAKR RGGGGHDALK GPNVCGSHYN AYCCPGWKTL PGGNQCIVPI CRHSCGDGFC
SRPNMCTCPS GQIAPSCGSR SIQHCSIRCM NGGSCSDDHC LCQKGYIGTH CGQPVCESGC
LNGGRCVAPN RCACTYGFTG PQCERDYRTG PCFTVVSNQM CQGQLSGIVC TKTLCCATVG
RAWGHPCEMC PAQPHPCRRG FIPNIRTGAC QDVDECQAIP GLCQGGNCIN TVGSFECKCP
AGHKFNEVSQ KCEDIDECST IPGICDGGEC TNTVSSYFCK CPPGFYTSPD GTRCIDVRPG
YCYTALANGR CSNQLPQSIT KMQCCCDAGR CWSPGVTVAP EMCPIRATED FNKLCSVPMV
IPGRPEYPPP PLGPIPPVLP VPPGFPSGPQ IPVPRPPVEY PYPSREPPRV LPVNVTDYCQ
LVRYLCQNGR CIPTPGSYRC ECNKGFQLDL RGECIDVDEC EKNPCAGGEC FNNQGSYTCQ
CRAGYQSTLT RTECRDIDEC LQNGRICNNG RCINTDGSFH CVCNAGFHVT RDGKNCEDMD
ECSIRNMCLN GMCINEDGSF KCICKPGFQL ASDGRYCKDI NECETPGICM NGRCVNTDGS
YRCECFPGLA VGLDGRVCVD THMRSTCYGG YKRGQCIKPL FGAVTKSECC CASTEYAFGE
PCQPCPAQNS AEYQALCSSG PGMTSAGSDI NECALDPDIC PNGICENLRG TYKCICNSGY
EVDSTGKNCV DINECVLNSL LCDNGQCRNT PGSFVCTCPK GFIYKPDLKT CEDIDECESS
PCINGVCKNS PGSFICECSS ESTLDPTKTI CIETIKGTCW QTVTIDGRCE ININGATLKS
QCCSSLGAAW GSPCTPCQVD PICGKGYSRI KGTQCEDIDE CEVFPGVCKN GLCVNTRGSF
KCECPNGMTL DATGRICLDI RLETCYLRYE DEECTLPIAG RHRMDACCCS VGAAWGTEEC
EECPMRNTPE YEELCPRGPG FATKEITNGK PFFKDINECK MIPSLCTHGK CRNTIGSFKC
RCDSGFALDS EERNCTDIDE CRISPDLCGR GQCVNTPGDF ECKCDEGYES GFMMMKNCMD
IDECQRDPLL CRGGVCHNTE GSYRCECPPG HQLSPNISAC IDINECELSA HLCPNGRCVN
LIGKYQCTCN PGYHSTPDRL FCVDIDECSI MNGGCETFCT NSEGSYECSC QPGFALMPDQ
RSCTDIDECE DNPNICDGGQ CTNIPGEYRC LCYDGFMASE DMKTCVDVNE CDLNPNICLS
GTCENTKGSF ICHCDMGYSG KKGKTGCTDI NECEIGAHNC GRHAVCTNTA GSFKCSCSPG
WIGDGIKCSD LDECSNGTHM CSQHADCKNT MGSYRCLCKE GYTGDGFTCT DLDECSENLN
LCGNGQCLNA PGGYRCECDM GFVPSADGKA CEDIDECSLP NICVFGTCHN LPGLFRCECE
IGYELDRSGG NCTDVNECLD PTTCISGNCI NTPGSYTCDC PPDFELNPTR VGCVDTRSGN
CYLDIRPRGD NGDTACSNEI GVGVSKASCC CSLGKAWGTP CEMCPAVNTS EYKILCPGGE
GFRPNPITVI LEDIDECQEL PGLCQGGKCI NTFGSFQCRC PTGYYLNEDT RVCDDVNECE
TPGICGPGTC YNTVGNYTCI CPPDYMQVNG GNNCMDMRRS LCYRNYYADN QTCDGELLFN
MTKKMCCCSY NIGRAWNKPC EQCPIPSTDE FATLCGSQRP GFVIDIYTGL PVDIDECREI
PGVCENGVCI NMVGSFRCEC PVGFFYNDKL LVCEDIDECQ NGPVCQRNAE CINTAGSYRC
DCKPGYRFTS TGQCNDRNEC QEIPNICSHG QCIDTVGSFY CLCHTGFKTN ADQTMCLDIN
ECERDACGNG TCRNTIGSFN CRCNHGFILS HNNDCIDVDE CASGNGNLCR NGQCINTVGS
FQCQCNDGYE VAPDGRTCVD INECLLEPGK CAPGTCQNLD GSYRCICPPG YSLQNDKCED
IDECVEEPEI CALGTCSNTE GSFKCLCPEG FSLSSTGRRC QDLRMSYCYA KFEGGKCSSP
KSRNHSKQEC CCALKGEGWG DPCELCPTEP DEAFRQICPY GSGIIVGPDD SAVDMDECKE
PDVCKHGQCI NTDGSYRCEC PFGYILAGNE CVDTDECSVG NPCGNGTCKN VIGGFECTCE
EGFEPGPMMT CEDINECAQN PLLCAFRCVN TYGSYECKCP VGYVLREDRR MCKDEDECEE
GKHDCTEKQM ECKNLIGTYM CICGPGYQRR PDGEGCVDEN ECQTKPGICE NGRCLNTRGS
YTCECNDGFT ASPNQDECLD NREGYCFTEV LQNMCQIGSS NRNPVTKSEC CCDGGRGWGP
HCEICPFQGT VAFKKLCPHG RGFMTNGADI DECKVIHDVC RNGECVNDRG SYHCICKTGY
TPDITGTSCV DLNECNQAPK PCNFICKNTE GSYQCSCPKG YILQEDGRSC KDLDECATKQ
HNCQFLCVNT IGGFTCKCPP GFTQHHTACI DNNECTSDIN LCGSKGICQN TPGSFTCECQ
RGFSLDQTGS SCEDVDECEG NHRCQHGCQN IIGGYRCSCP QGYLQHYQWN QCVDENECLS
AHICGGASCH NTLGSYKCMC PAGFQYEQFS GGCQDINECG SSQAPCSYGC SNTEGGYLCG
CPPGYFRIGQ GHCVSGMGMG RGNPEPPVSG EMDDNSLSPE ACYECKINGY PKRGRKRRSA
NETDASHIEL LQPFSQLRSA QILTHTSGSR PIESSTCGPI EARKKPGSV
//
